13 research outputs found
Enhanced production of flavonoids by methyl jasmonate elicitation in cell suspension culture of Hypericum perforatum
Management of acute skin toxicity with Hypericum perforatum and neem oil during platinum-based concurrent chemo-radiation in head and neck cancer patients
Integrated Metabolomics and Phytochemical Genomics Approaches for Studies on St. John’s Wort
Cytotoxic activities of Hypericum perforatum L. extracts against 2D and 3D cancer cell models
Biological evaluation of hyperforin and its hydrogenated analogue on bacterial growth and biofilm production
Bacterial biofilms are organized communities of microorganisms, embedded in a self-produced matrix, growing on a biotic surface and resistant to many antimicrobial agents when associated with a medical device. These biofilms require the development of new strategies for the prevention and treatment of infectious disease, including the potential use of natural products. One interesting natural product example is Hypericum, a plant genus that contains species known to have antimicrobial properties. The major constituent of Hypericum perforatum is an unstable compound named hyperforin (1); for this reason it was not believed to play a significant role in the pharmacological effects. In this investigation a hydrogenated hyperforin analogue (2) was tested on several ATCC and clinical isolate strains, in their planktonic and biofilm form (Staphylococcus aureus, MRSA, and Enterococcus faecalis). Compound 2 was effective against planktonic and biofilm cultures, probably due to higher stability, showing the percentage of cells killed in the range from 452 2013 The American Chemical Society and American Society of Pharmacognosy