Close range photogrammetry in the survey of the coastal area geoecological conditions (on the example of Portugal)

Close range digital photogrammetry, which involves the application of unmanned aerial vehicle (UAV), has been used in a growing number of diverse applications across different scientific disciplines. Our objective was to use the mentioned method in the survey of the contemporary geoecological conditions of the coastal area on the example of Portuguese northwest coastal zone. The coastal zone can be subdivided into two geomorphological sectors: Sector 1, between the Minho River and the town of Espinho, where the coastal segments consist of estuaries, sandy and shingle beaches with rocky outcrops, and Holocene dune systems. The estuaries and the foredunes in particular are very degraded by human activities; and Sector 2, between Espinho and the Mondego Cape, where coastal lagoons and Holocene dune systems occur. We chose two beaches for surveying – Aguçadoura and Ramalha to which the drone swinglet CAM took the photos. We used the ground control software eMotion 2 to plan the flights over the study area and controlled the drone’s trajectory during flight. After processing the obtained images in the program of AgisoftPhotoscanPro, we generated the 2D orthophotos and 3D digital elevation models (DEM) of the research sections. At this stage of study we derived the above product without using the ground control points, or we used only the camera GPS data. Based on these models the compilation of the large-scale maps of high resolution (1cm-5cm) will be possible in the GISs for monitoring and management of the geoecological state of the mentioned beaches in case to precise the x, y and z values of the models with the geodetic device of Differential GPSs in the selected ground control points (GCP).We are grateful to the European Commission ERASMUS-MUNDUS Action-2 ELECTRA program and the Earth Sciences Centre of the University of Minho (Braga, Portugal) in supporting us to conduct the field works and research.info:eu-repo/semantics/publishedVersio

Characterizing Van Kampen Squares via Descent Data

Categories in which cocones satisfy certain exactness conditions w.r.t. pullbacks are subject to current research activities in theoretical computer science. Usually, exactness is expressed in terms of properties of the pullback functor associated with the cocone. Even in the case of non-exactness, researchers in model semantics and rewriting theory inquire an elementary characterization of the image of this functor. In this paper we will investigate this question in the special case where the cocone is a cospan, i.e. part of a Van Kampen square. The use of Descent Data as the dominant categorical tool yields two main results: A simple condition which characterizes the reachable part of the above mentioned functor in terms of liftings of involved equivalence relations and (as a consequence) a necessary and sufficient condition for a pushout to be a Van Kampen square formulated in a purely algebraic manner.Comment: In Proceedings ACCAT 2012, arXiv:1208.430

Blood-based biomarkers for Alzheimer disease: mapping the road to the clinic.

Biomarker discovery and development for clinical research, diagnostics and therapy monitoring in clinical trials have advanced rapidly in key areas of medicine - most notably, oncology and cardiovascular diseases - allowing rapid early detection and supporting the evolution of biomarker-guided, precision-medicine-based targeted therapies. In Alzheimer disease (AD), breakthroughs in biomarker identification and validation include cerebrospinal fluid and PET markers of amyloid-β and tau proteins, which are highly accurate in detecting the presence of AD-associated pathophysiological and neuropathological changes. However, the high cost, insufficient accessibility and/or invasiveness of these assays limit their use as viable first-line tools for detecting patterns of pathophysiology. Therefore, a multistage, tiered approach is needed, prioritizing development of an initial screen to exclude from these tests the high numbers of people with cognitive deficits who do not demonstrate evidence of underlying AD pathophysiology. This Review summarizes the efforts of an international working group that aimed to survey the current landscape of blood-based AD biomarkers and outlines operational steps for an effective academic-industry co-development pathway from identification and assay development to validation for clinical use.I recieved an honorarium from Roche Diagnostics for my participation in the advisory panel meeting leading to this pape

Neurovascular unit dysfunction with blood-brain barrier hyperpermeability contributes to major depressive disorder: a review of clinical and experimental evidence

About one-third of people with major depressive disorder (MDD) fail at least two antidepressant drug trials at 1 year. Together with clinical and experimental evidence indicating that the pathophysiology of MDD is multifactorial, this observation underscores the importance of elucidating mechanisms beyond monoaminergic dysregulation that can contribute to the genesis and persistence of MDD. Oxidative stress and neuroinflammation are mechanistically linked to the presence of neurovascular dysfunction with blood-brain barrier (BBB) hyperpermeability in selected neurological disorders, such as stroke, epilepsy, multiple sclerosis, traumatic brain injury, and Alzheimer’s disease. In contrast to other major psychiatric disorders, MDD is frequently comorbid with such neurological disorders and constitutes an independent risk factor for morbidity and mortality in disorders characterized by vascular endothelial dysfunction (cardiovascular disease and diabetes mellitus). Oxidative stress and neuroinflammation are implicated in the neurobiology of MDD. More recent evidence links neurovascular dysfunction with BBB hyperpermeability to MDD without neurological comorbidity. We review this emerging literature and present a theoretical integration between these abnormalities to those involving oxidative stress and neuroinflammation in MDD. We discuss our hypothesis that alterations in endothelial nitric oxide levels and endothelial nitric oxide synthase uncoupling are central mechanistic links in this regard. Understanding the contribution of neurovascular dysfunction with BBB hyperpermeability to the pathophysiology of MDD may help to identify novel therapeutic and preventative approaches

An axiomatic survey of diagram lemmas for non-abelian group-like structures

NatuurwetenskappeWiskundePlease help us populate SUNScholar with the post print version of this article. It can be e-mailed to: [email protected]

Closedness properties of internal relations VI: Approximate operations

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Split Short Five Lemma for Clots and Subtractive Categories

It is well-known that a pointed variety is classically ideal determined (or “BIT speciale”) if and only if it satisfies the split short five lemma (i.e. if and only if it is a protomodular category in the sense of D. Bourn). A much weaker property than being classically ideal determined is “subtractivity”, defined as follows: a variety with a constant 0 is said to be subtractive if its theory contains a binary term s satisfying s(x,x) = 0 and s(x,0) = x. In the case of a pointed variety (i.e. when 0 is the unique constant), this condition can be reformulated purely categorically (as many other similar term conditions), which gives rise to the notion of a subtractive category. In the present paper we show that in a certain general categorical context subtractivity is equivalent to a special restriction of the split short five lemma to the class of clots, i.e. monomorphisms that are pullbacks of reflexive relations R→Y×Y along product injections (1 Y ,0): Y→Y×Y

Categorical (binary) difference terms and protomodularity

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