Six-Dimensional (1,0) Superconformal Models and Higher Gauge Theory

We analyze the gauge structure of a recently proposed superconformal field theory in six dimensions. We find that this structure amounts to a weak Courant-Dorfman algebra, which, in turn, can be interpreted as a strong homotopy Lie algebra. This suggests that the superconformal field theory is closely related to higher gauge theory, describing the parallel transport of extended objects. Indeed we find that, under certain restrictions, the field content and gauge transformations reduce to those of higher gauge theory. We also present a number of interesting examples of admissible gauge structures such as the structure Lie 2-algebra of an abelian gerbe, differential crossed modules, the 3-algebras of M2-brane models and string Lie 2-algebras.Comment: 31+1 pages, presentation slightly improved, version published in JM

Gunung Tahan Trail: a historical review

There are still a lot of information on the history of Gunung Tahan Trail which remain unknown to the Malaysian public; some were buried with the demise of the elderly living around this mountain. This paper attempts to reveal the history of this famous trail which is located in Taman Negara in relation to the origin of its name, local belief and folklore of the mountain, colonial proposal for the establishment of grand hill station and early attempts to explore the mountain. Most of the data and information for this review were gathered from field notes and expedition reports published in various journals between 1880 and 1940. These information would be useful to Taman Negara Park Management in enriching recreational and nature tourism experiences among users of Gunung Tahan Trail

Stable photon orbits in stationary axisymmetric electrovacuum spacetimes

We investigate the existence and phenomenology of stable photon orbits (SPOs) in stationary axisymmetric electrovacuum spacetimes in four dimensions. First, we review the classification of equatorial circular photon orbits on Kerr-Newman spacetimes in the charge-spin plane. Second, using a Hamiltonian formulation, we show that Reissner-Nordström diholes (a family encompassing the Majumdar-Papapetrou and Weyl-Bach special cases) admit SPOs, in a certain parameter regime that we investigate. Third, we explore the transition from order to chaos for typical SPOs bounded within a toroidal region around a dihole, via a selection of Poincaré sections. Finally, for general axisymmetric stationary spacetimes, we show that the Einstein-Maxwell field equations allow for the existence of SPOs in electro vacuum, but not in pure vacuum

Hybrid Topology of Substrate Integrated Waveguide (SIW) Filter and Microstrip Patch Antenna for Wireless Communication System

This paper presents an analysis based upon the resonant circuit approach to develop hybrid system for integrating a microwave filter and an antenna in a single device. This technique is used to reduce the overall volume of RF/ microwave front-end device especially in wireless communication systems. This study focuses on the hybrid of rectangular Substrate Integrated Waveguide (SIW) filter with rectangular microstrip patch antenna to produce filtering and radiating element in a single system. To prove the concept, the hybrid of microwave filter and antenna, the operating frequency of 2 GHz is demonstrated and validated through simulation and experimental. The experimental performance shows promising results which were in good agreement with the simulated results particularly in exhibiting return loss better than 10 dB in the passband region. This study is useful for any hybrid microwave system whereby it can reduce the complexity of the design, weight and cost as it is very important in base stations and multiplexer in any wireless communication systems

Scalability challenges in healthcare blockchain system - a systematic review

Blockchain technology is a private, secure, trustworthy, and transparent information exchange performed in a decentralised manner. In this case, the coordination and validation efforts are simplified as the records are designed to update regularly and there is no difference in the two databases. This review focuses on how the blockchain addresses scalability challenges and provides solutions in the healthcare field through the implementation of blockchain technology. Accordingly, 16 solutions fell under two main areas, namely storage optimization and redesign of blockchain. However, limitations persist, including block size, high volume of data, transactions, number of nodes, and protocol challenges. This review consists of six stages, namely identification of research question, procedures of research, screening of relevant articles, keywording based on the abstract, data extraction, and mapping process. Through Atlas.ti software, the selected keywords were used to analyse through the relevant articles. As a result, 48 codes and 403 quotations were compiled. Manual coding was performed to categorise the quotations. The codes were then mapped onto the network as a mapping process. Notably, 16 solutions fell under two main areas, namely storage optimization and redesign of blockchain. Basically, there are 3 solutions compiled for storage optimization and 13 solutions for the redesign of the blockchain, namely blockchain modelling, read mechanism, write mechanism, and bi-directional network

Repurposing the aldose reductase inhibitor and diabetic neuropathy drug epalrestat for the congenital disorder of glycosylation PMM2-CDG

Phosphomannomutase 2 deficiency, or PMM2-CDG, is the most common congenital disorder of glycosylation and affects over 1000 patients globally. There are no approved drugs that treat the symptoms or root cause of PMM2-CDG. To identify clinically actionable compounds that boost human PMM2 enzyme function, we performed a multispecies drug repurposing screen using a novel worm model of PMM2-CDG, followed by PMM2 enzyme functional studies in PMM2-CDG patient fibroblasts. Drug repurposing candidates from this study, and drug repurposing candidates from a previously published study using yeast models of PMM2-CDG, were tested for their effect on human PMM2 enzyme activity in PMM2-CDG fibroblasts. Of the 20 repurposing candidates discovered in the worm-based phenotypic screen, 12 were plant-based polyphenols. Insights from structure-activity relationships revealed epalrestat, the only antidiabetic aldose reductase inhibitor approved for use in humans, as a first-in-class PMM2 enzyme activator. Epalrestat increased PMM2 enzymatic activity in four PMM2-CDG patient fibroblast lines with genotypes R141H/F119L, R141H/E139K, R141H/N216I and R141H/F183S. PMM2 enzyme activity gains ranged from 30% to 400% over baseline, depending on genotype. Pharmacological inhibition of aldose reductase by epalrestat may shunt glucose from the polyol pathway to glucose-1,6-bisphosphate, which is an endogenous stabilizer and coactivator of PMM2 homodimerization. Epalrestat is a safe, oral and brain penetrant drug that was approved 27 years ago in Japan to treat diabetic neuropathy in geriatric populations. We demonstrate that epalrestat is the first small molecule activator ofPMM2 enzyme activity with the potential to treat peripheral neuropathy and correct the underlying enzyme deficiency in a majority of pediatric and adult PMM2-CDG patients

Stability of gravitating charged-scalar solitons in a cavity

We present new regular solutions of Einstein-charged scalar field theory in a cavity. The system is enclosed inside a reflecting mirror-like boundary, on which the scalar field vanishes. The mirror is placed at the zero of the scalar field closest to the origin, and inside this boundary our solutions are regular. We study the stability of these solitons under linear, spherically symmetric perturbations of the metric, scalar and electromagnetic fields. If the radius of the mirror is sufficiently large, we present numerical evidence for the stability of the solitons. For small mirror radius, some of the solitons are unstable. We discuss the physical interpretation of this instability

Binary black hole shadows, chaotic scattering and the Cantor set

We investigate the qualitative features of binary black hole shadows using the model of two extremally charged black holes in static equilibrium (a Majumdar–Papapetrou solution). Our perspective is that binary spacetimes are natural exemplars of chaotic scattering, because they admit more than one fundamental null orbit, and thus an uncountably infinite set of perpetual null orbits which generate scattering singularities in initial data. Inspired by the three-disc model, we develop an appropriate symbolic dynamics to describe planar null geodesics on the double black hole spacetime. We show that a one-dimensional (1D) black hole shadow may constructed through an iterative procedure akin to the construction of the Cantor set; thus the 1D shadow is self-similar. Next, we study non-planar rays, to understand how angular momentum affects the existence and properties of the fundamental null orbits. Taking slices through 2D shadows, we observe three types of 1D shadow: regular, Cantor-like, and highly chaotic. The switch from Cantor-like to regular occurs where outer fundamental orbits are forbidden by angular momentum. The highly chaotic part is associated with an unexpected feature: stable and bounded null orbits, which exist around two black holes of equal mass M separated by a1 < a < √ 2a1, where a1 = 4M/√ 27. To show how this possibility arises, we define a certain potential function and classify its stationary points. We conjecture that the highly chaotic parts of the 2D shadow possess the Wada property. Finally, we consider the possibility of following null geodesics through event horizons, and chaos in the maximally extended spacetime