156 research outputs found
Multi-filament structures in relativistic self-focusing
A simple model is derived to prove the multi-filament structure of
relativistic self-focusing with ultra-intense lasers. Exact analytical
solutions describing the transverse structure of waveguide channels with
electron cavitation, for which both the relativistic and ponderomotive
nonlinearities are taken into account, are presented.Comment: 21 pages, 12 figures, submitted to Physical Review
Optimal use of time dependent probability density data to extract potential energy surfaces
A novel algorithm was recently presented to utilize emerging time dependent
probability density data to extract molecular potential energy surfaces. This
paper builds on the previous work and seeks to enhance the capabilities of the
extraction algorithm: An improved method of removing the generally ill-posed
nature of the inverse problem is introduced via an extended Tikhonov
regularization and methods for choosing the optimal regularization parameters
are discussed. Several ways to incorporate multiple data sets are investigated,
including the means to optimally combine data from many experiments exploring
different portions of the potential. Results are presented on the stability of
the inversion procedure, including the optimal combination scheme, under the
influence of data noise. The method is applied to the simulated inversion of a
double well system.Comment: 34 pages, 5 figures, LaTeX with REVTeX and Graphicx-Package;
submitted to PhysRevA; several descriptions and explanations extended in Sec.
I
Gain in Stochastic Resonance: Precise Numerics versus Linear Response Theory beyond the Two-Mode Approximation
In the context of the phenomenon of Stochastic Resonance (SR) we study the
correlation function, the signal-to-noise ratio (SNR) and the ratio of output
over input SNR, i.e. the gain, which is associated to the nonlinear response of
a bistable system driven by time-periodic forces and white Gaussian noise.
These quantifiers for SR are evaluated using the techniques of Linear Response
Theory (LRT) beyond the usually employed two-mode approximation scheme. We
analytically demonstrate within such an extended LRT description that the gain
can indeed not exceed unity. We implement an efficient algorithm, based on work
by Greenside and Helfand (detailed in the Appendix), to integrate the driven
Langevin equation over a wide range of parameter values. The predictions of LRT
are carefully tested against the results obtained from numerical solutions of
the corresponding Langevin equation over a wide range of parameter values. We
further present an accurate procedure to evaluate the distinct contributions of
the coherent and incoherent parts of the correlation function to the SNR and
the gain. As a main result we show for subthreshold driving that both, the
correlation function and the SNR can deviate substantially from the predictions
of LRT and yet, the gain can be either larger or smaller than unity. In
particular, we find that the gain can exceed unity in the strongly nonlinear
regime which is characterized by weak noise and very slow multifrequency
subthreshold input signals with a small duty cycle. This latter result is in
agreement with recent analogue simulation results by Gingl et al. in Refs. [18,
19].Comment: 22 pages, 5 eps figures, submitted to PR
Open Problems on Central Simple Algebras
We provide a survey of past research and a list of open problems regarding
central simple algebras and the Brauer group over a field, intended both for
experts and for beginners.Comment: v2 has some small revisions to the text. Some items are re-numbered,
compared to v
Ultrashort filaments of light in weakly-ionized, optically-transparent media
Modern laser sources nowadays deliver ultrashort light pulses reaching few
cycles in duration, high energies beyond the Joule level and peak powers
exceeding several terawatt (TW). When such pulses propagate through
optically-transparent media, they first self-focus in space and grow in
intensity, until they generate a tenuous plasma by photo-ionization. For free
electron densities and beam intensities below their breakdown limits, these
pulses evolve as self-guided objects, resulting from successive equilibria
between the Kerr focusing process, the chromatic dispersion of the medium, and
the defocusing action of the electron plasma. Discovered one decade ago, this
self-channeling mechanism reveals a new physics, widely extending the frontiers
of nonlinear optics. Implications include long-distance propagation of TW beams
in the atmosphere, supercontinuum emission, pulse shortening as well as
high-order harmonic generation. This review presents the landmarks of the
10-odd-year progress in this field. Particular emphasis is laid to the
theoretical modeling of the propagation equations, whose physical ingredients
are discussed from numerical simulations. Differences between femtosecond
pulses propagating in gaseous or condensed materials are underlined. Attention
is also paid to the multifilamentation instability of broad, powerful beams,
breaking up the energy distribution into small-scale cells along the optical
path. The robustness of the resulting filaments in adverse weathers, their
large conical emission exploited for multipollutant remote sensing, nonlinear
spectroscopy, and the possibility to guide electric discharges in air are
finally addressed on the basis of experimental results.Comment: 50 pages, 38 figure
Endocrine Therapy Synergizes with SMAC Mimetics to Potentiate Antigen Presentation and Tumor Regression in Hormone Receptor-Positive Breast Cancer.
UNLABELLED: Immunotherapies have yet to demonstrate significant efficacy in the treatment of hormone receptor-positive (HR+) breast cancer. Given that endocrine therapy (ET) is the primary approach for treating HR+ breast cancer, we investigated the effects of ET on the tumor immune microenvironment (TME) in HR+ breast cancer. Spatial proteomics of primary HR+ breast cancer samples obtained at baseline and after ET from patients enrolled in a neoadjuvant clinical trial (NCT02764541) indicated that ET upregulated β2-microglobulin and influenced the TME in a manner that promotes enhanced immunogenicity. To gain a deeper understanding of the underlying mechanisms, the intrinsic effects of ET on cancer cells were explored, which revealed that ET plays a crucial role in facilitating the chromatin binding of RelA, a key component of the NF-κB complex. Consequently, heightened NF-κB signaling enhanced the response to interferon-gamma, leading to the upregulation of β2-microglobulin and other antigen presentation-related genes. Further, modulation of NF-κB signaling using a SMAC mimetic in conjunction with ET augmented T-cell migration and enhanced MHC-I-specific T-cell-mediated cytotoxicity. Remarkably, the combination of ET and SMAC mimetics, which also blocks prosurvival effects of NF-κB signaling through the degradation of inhibitors of apoptosis proteins, elicited tumor regression through cell autonomous mechanisms, providing additional support for their combined use in HR+ breast cancer. SIGNIFICANCE: Adding SMAC mimetics to endocrine therapy enhances tumor regression in a cell autonomous manner while increasing tumor immunogenicity, indicating that this combination could be an effective treatment for HR+ patients with breast cancer
Ultrafast laser micro-nano structuring of transparent materials with high aspect ratio
Ultrafast lasers are ideal tools to process transparent materials because
they spatially confine the deposition of laser energy within the material's
bulk via nonlinear photoionization processes. Nonlinear propagation and
filamentation were initially regarded as deleterious effects. But in the last
decade, they turned out to be benefits to control energy deposition over long
distances. These effects create very high aspect ratio structures which have
found a number of important applications, particularly for glass separation
with non-ablative techniques. This chapter reviews the developments of
in-volume ultrafast laser processing of transparent materials. We discuss the
basic physics of the processes, characterization means, filamentation of
Gaussian and Bessel beams and provide an overview of present applications
- …