Phraseology and institutional discourse: Angela Merkel

Linguosemiotic approach to the study of phraseological units used by an institutional language personality. The language personality of a politician, in particular Angela Merkel, is considered as an active mechanism for the functioning of institutional discours

Optical coherence tomography angiography as an indicator of the efficacy of treatment for choroidal neovascularization

Background: Choroidal neovascularization (CNV) occurs in as much as 11.3% of patients with pathological myopia, and is a major cause of visual disability associated with irreversible loss of central vision. The advent of optical coherence tomography angiography (OCTA) has opened up new opportunities for objective documentation and real-time qualitative and quantitative evaluation of CNV in the course of therapy. Purpose: To assess the efficacy of anti-vascular epithelium growth factor (VEGF) therapy with ranibizumab in CNV associated with pathological myopia using OCTA. Material and Methods: Thirty seven anti-VEGF-treatment naive patients (37 eyes) with myopic CNV were involved in the study. All study participants received an intravitreal ranibizumab injection (in accordance with the manufacturer’s recommendations) followed by as needed (PRN) retreatment. Results: Complete subretinal fluid resorption with adherence of the neurosensory retina was observed in all the 37 eyes; the mean number of intravitreal ranibizumab injections required was 4.56 ± 0.1. Over the 18-month follow up period, best-corrected visual acuity (BCVA) improved from 0.12 ± 0.03 to 0.42 ± 0.04 in 27 eyes (72.97%). OCTA patterns of CNV activity tended to fade, with the characteristic presence of isolated long filamentous vessels having a “dead tree” appearance. Conclusion: Application of OCTA, an information-rich modality, in pathological myopia, facilitates a personalized approach to determining the need for anti-VEGF therapy and selecting the mode of administration of anti-VEGF agents based on the CNV activity

Juchi Khan Mausoleum: realities, legends and rituals

Lore and folk legends designate the burial of Jochi Khan, the eldest son of Genghis Khan, in the eponymous mausoleum in Ulytau, Kazakhstan. The mausoleum was built according to Islamic architecture of the 14th-15th centuries. A.Kh. Margulan, the author of archeological excavations, relying mostly on the folk legends designated the mausoleum’s burial to Jochi Khan. Radiocarbon dating of mausoleum determines two stages of its construction throughout the 14th century and the burial box age later than the death of Jochi Khan in 1225. New evidence from the mausoleum architecture and artifacts suggests that Jochi's burial is not in the mausoleum but a secret place prescribed by the Chinggisid canon. The assembly of Islamic and pre-Islamic traditions and the camel skull found in the burial indicates that the burial was made for a person of Islamic faith from the Golden Horde. Whereas the mausoleum was named in the honor of Jochi Khan

ИЗУЧЕНИЕ ПОКАЗАТЕЛЕЙ БЕЗОПАСНОСТИ ЗЕРНОВОГО ПРОДУКТА «ЗЛАКОВЫЙ БАТОНЧИК»

The study of food products is the most important method for creating proves of their food safety based on generally accepted scientific ideas and current international and national legal norms of food safety. At the stage of laboratory research it is possible to objectively prove the efficiency and safety of new types of food products while their consumption according to certain health indications among the relevant group of people, including staff working in hazardous industrial environment. In the Russian Federation the procedure for assessing the safety and running the laboratory tests of food products are regulated by the Federal Laws on the Quality and Safety of Food Products, regulations on provision of public catering services, methodological recommendations for assessing the risk to public health in case of exposure to microbial factors contained in food products, as well as technical regulations of the Customs Union on food safety. The authors have developed regulatory and technical documentation for the cereal product “Cereal bar” and presented data on its safety when consumed. Conclusions about the product are made on the basis of a study of its chronic toxicity. It has been established that the ingredients composition of the cereal bar, included in the diet of laboratory animals, provided a positive effect on their body condition, weight gain and did not cause abnormal changes in the volume of internal organs and the development of pathologies that could indicate a side effect of the product. During study of the hematological and biochemical parameters, no significant differences were found between the data of the control group and experimental group of the animals. The conducted studies of the cereal product “Cereal bar” confirm the absence of a potential risk of developing chronic toxicity in case of introduction of the cereal bar to the animals’ diets and its consumption over a long period of time.Исследование пищевых продуктов является важнейшим инструментом построения доказательной базы их безопасности исходя из общепринятых научных представлений и действующих международных и национальных правовых норм. На этапе лабораторных исследований можно объективно доказать эффективность и безопасность новых видов пищевой продукции при применении по определенным показаниям у соответствующего контингента лиц, в том числе работающих во вредных производственных условиях. В Российской Федерации порядок оценки безвредности и проведение лабораторных исследований продуктов питания регламентируются Федеральными законами о качестве и безопасности пищевых продуктов, постановлениями об оказании услуг общественного питания, методическими рекомендациями по оценке риска здоровью населения при воздействии факторов микробной природы, содержащихся в пищевых продуктах, а также техническим регламентом Таможенного союза о безопасности пищевой продукции. Авторами разработана нормативно-техническая документация на зерновой продукт «Злаковый батончик» и представлены данные о его безвредности при употреблении в пищу Выводы о продукте сделаны на основе изучения его хронической токсичности. Установлено, что ингредиентный состав злакового батончика, включенного в рацион питания лабораторных животных, положительно влияет на прирост массы их тела и не вызывает аномального изменения объема внутренних органов и развития патологий, которые могли бы свидетельствовать о побочном действии продукта. В процессе изучения гематологических и биохимических показателей не найдено достоверных отличий между данными контрольной и опытных групп животных. Проведенные исследования зернового продукта «Злаковый батончик» подтверждают отсутствие потенциальной опасности развития хронической токсичности при добавлении его в рационы питания и употреблении в течение длительного периода времени

О разработке новых опросников качества жизни при онкологической патологии

The article is devoted to summarizing the authors’ experience in the development of Russian-language versions of foreign quality of life questionnaires for cancer patients as well as their own questionnaires for studying various aspects of the quality of life in bone and soft tissue tumors of the musculoskeletal system. We briefly presented the results of the validation and testing of the modules of the «Cancer Quality of Life Questionnaire - Core 30» (EORTC QLQ-C30) developed by the Quality of Life Assessment Group at the European Organization for Research and Treatment of Cancer (EORTC) – «Fatigue» module (FA12), «Spiritual wellbeing» module (SWB32), «Bone Metastases» module (BM22), as well as the specialized Spine Oncology Study Group Outcomes Questionnaire (SOSG-OQ). We also presented the diagnostic tools developed by the authors’ themselves for studying the quality of life of patients with pelvic bone tumors and lower limb amputations due to cancer. The main objective of the article was to inform the scientific community, as well as practicing psycho-oncologists and oncologists about the existence of new diagnostic tools for assessing the quality of life of cancer patients. The article also outlines the prospects for development of diagnostic tools for quality of life of cancer patients. Статья посвящена обобщению опыта авторов в разработке русскоязычных версий зарубежных опросников качества жизни при онкологических заболеваниях, а также собственных опросников для изучения различных аспектов качества жизни при опухолях костей и мягких тканей опорно-двигательного аппарата. Кратко представлены результаты валидизации и апробации модулей «Опросника качества жизни при онкологической патологии» («Quality of Life Questionnaire-Core 30», EORTC QLQ-C30), разработанного Группой оценки качества жизни при Европейской организации лечения и исследования рака (EORTC Study Group on Quality of Life) – модуля «Fatigue» («Утомление») (FA12), модуля «Spiritual Wellbeing» («Духовное благополучие») (SWB32), модуля «Bone Metastases» («Качество жизни при опухолях костей») (BM22), а также специализированного «Опросника качества жизни при опухолях позвоночника» («Spine Oncology Study Group Outcomes Questionnaire», SOSG-OQ); представлены собственные разработки авторов для изучения качества жизни пациентов с опухолями костей таза и пациентов, перенесших ампутацию нижней конечности в связи с онкологическим заболеванием. Основная цель статьи – информирование научной общественности, а также практикующих онкопсихологов и онкологов о существовании ряда новых диагностических инструментов для оценки качества жизни онкологических больных. Намечены перспективы разработки инструментов диагностики качества жизни онкологических больных.

Analysis of the characteristics of dental status and level of dental health in young adults

The article deals with topical issues of prevalence and intensity of major dental diseases, as well as the level of oral hygiene, which plays a key role in their development. The decrease in the level of dental health of young people creates a growing demand for the treatment of diseases of hard tissues of teeth, inflammatory diseases of periodontal tissues and oral mucosa, the need for orthodontic treatment and prosthetics.В статье рассматриваются актуальные вопросы распространенности и интенсивности основных стоматологических заболеваний, а также уровня гигиены полости рта, которая играет ключевую роль в их развитии. Снижение показателей уровня стоматологического здоровья лиц молодого возраста формирует усиление спроса на лечение заболеваний твердых тканей зубов, воспалительных заболеваний тканей пародонта и слизистой оболочки рта, потребность в ортодонтическом лечении и протезировании

Результаты геодезических измерений баланса массы некоторых ледников Заилийского Алатау

SummaryThe current state and mass balance of some glaciers of the Trans-Ili Alatau (Zailiyskiy Alatau, Tien Shan, Kazakhstan) is estimated in the paper. The remote sensing data (images of the Pléiades satellites) and detailed field geodetic measurements (differential global positioning system with the South G6 instrument)were used for the analysis. The field works were carried out in August-September 2021on the northern slope of the Zailiyskiy Alatau ridge. A digital relief model had been built for the analysis as well. Negative trends in the area of the studied glaciers have been revealed, which generally correspond to the average rate of degradation of the glaciation of the Trans-Ili Alatau from 1955 to the present. A comparison of glaciological (contact, i.e., obtained as a result of measurements made on the glacier) and geodetic (resulted from analysis of remote sensing data) methods for estimating the annual mass balance of the Central Tuyuksu glacier for the period 2016-2021 showed that the final values calculated by these two methods are very close in values. For example, the sum of annual balances calculated by the glaciological method for this period was -2.9 m w.e., or -0.58 a-1 m w.e. per a year, while the balance calculated by the geodetic method for the same period was - 0.63 a-1 m w.e. Thus, the results of comparison of the above methods of the glacier mass-balance investigation confirm that the geodetic one based on satellite measurements and the ground surveys using the South G6 instrument is in a good agreement with results of glaciological methods of measurements and calculations.Деградация оледенения вызывает изменения в горных экосистемах, оказывая непосредственное влияние на жизнедеятельность людей, вызывает изменения в гидрологическом режиме, биогеохимии рек и гляциальных озёр, влияя на качество и доступность водных ресурсов. Рассмотрены вопросы оценки баланса массы ледников северного склона Заилийского (Иле) Алатау посредством применения данных дистанционного зондирования Земли (ДЗЗ) в сочетании с полевыми исследованиями и измерениями

137 ancient human genomes from across the Eurasian steppes

Descriptive and Comparative Linguistic

The Origins and Spread of Domestic Horses from the Western Eurasian Steppes

Domestication of horses fundamentally transformed long-range mobility and warfare1. However, modern domesticated breeds do not descend from the earliest domestic horse lineage associated with archaeological evidence of bridling, milking and corralling2–4 at Botai, Central Asia around 3500 bc3. Other longstanding candidate regions for horse domestication, such as Iberia5 and Anatolia6, have also recently been challenged. Thus, the genetic, geographic and temporal origins of modern domestic horses have remained unknown. Here we pinpoint the Western Eurasian steppes, especially the lower Volga-Don region, as the homeland of modern domestic horses. Furthermore, we map the population changes accompanying domestication from 273 ancient horse genomes. This reveals that modern domestic horses ultimately replaced almost all other local populations as they expanded rapidly across Eurasia from about 2000 bc, synchronously with equestrian material culture, including Sintashta spoke-wheeled chariots. We find that equestrianism involved strong selection for critical locomotor and behavioural adaptations at the GSDMC and ZFPM1 genes. Our results reject the commonly held association7 between horseback riding and the massive expansion of Yamnaya steppe pastoralists into Europe around 3000 bc8,9 driving the spread of Indo-European languages10. This contrasts with the scenario in Asia where Indo-Iranian languages, chariots and horses spread together, following the early second millennium bc Sintashta culture11,12. © 2021, The Author(s).We thank all members of the AGES group at CAGT. We are grateful for the Museum of the Institute of Plant and Animal Ecology (UB RAS, Ekaterinburg) for providing specimens. The work by G. Boeskorov is done on state assignment of DPMGI SB RAS. This project was supported by the University Paul Sabatier IDEX Chaire d’Excellence (OURASI); Villum Funden miGENEPI research programme; the CNRS ‘Programme de Recherche Conjoint’ (PRC); the CNRS International Research Project (IRP AMADEUS); the France Génomique Appel à Grand Projet (ANR-10-INBS-09-08, BUCEPHALE project); IB10131 and IB18060, both funded by Junta de Extremadura (Spain) and European Regional Development Fund; Czech Academy of Sciences (RVO:67985912); the Zoological Institute ZIN RAS (АААА-А19-119032590102-7); and King Saud University Researchers Supporting Project (NSRSP–2020/2). The research was carried out with the financial support of the Russian Foundation for Basic Research (19-59-15001 and 20-04-00213), the Russian Science Foundation (16-18-10265, 20-78-10151, and 21-18-00457), the Government of the Russian Federation (FENU-2020-0021), the Estonian Research Council (PRG29), the Estonian Ministry of Education and Research (PRG1209), the Hungarian Scientific Research Fund (Project NF 104792), the Hungarian Academy of Sciences (Momentum Mobility Research Project of the Institute of Archaeology, Research Centre for the Humanities); and the Polish National Science Centre (2013/11/B/HS3/03822). This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie (grant agreement 797449). This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreements 681605, 716732 and 834616)

The origins and spread of domestic horses from the Western Eurasian steppes

Analysis of 273 ancient horse genomes reveals that modern domestic horses originated in the Western Eurasian steppes, especially the lower Volga-Don region.Domestication of horses fundamentally transformed long-range mobility and warfare(1). However, modern domesticated breeds do not descend from the earliest domestic horse lineage associated with archaeological evidence of bridling, milking and corralling(2-4) at Botai, Central Asia around 3500 bc(3). Other longstanding candidate regions for horse domestication, such as Iberia(5) and Anatolia(6), have also recently been challenged. Thus, the genetic, geographic and temporal origins of modern domestic horses have remained unknown. Here we pinpoint the Western Eurasian steppes, especially the lower Volga-Don region, as the homeland of modern domestic horses. Furthermore, we map the population changes accompanying domestication from 273 ancient horse genomes. This reveals that modern domestic horses ultimately replaced almost all other local populations as they expanded rapidly across Eurasia from about 2000 bc, synchronously with equestrian material culture, including Sintashta spoke-wheeled chariots. We find that equestrianism involved strong selection for critical locomotor and behavioural adaptations at the GSDMC and ZFPM1 genes. Our results reject the commonly held association(7) between horseback riding and the massive expansion of Yamnaya steppe pastoralists into Europe around 3000 bc(8,9) driving the spread of Indo-European languages(10). This contrasts with the scenario in Asia where Indo-Iranian languages, chariots and horses spread together, following the early second millennium bc Sintashta culture(11,12).Descriptive and Comparative Linguistic