The connection between Neuroblastoma Amplified Sequence Gene (NBAS) and the Short Stature-Optic-Atrophy-Pelger-Huet Anomaly Syndrome (SOPH) literature review

Background. Clinical and natural heterogeneity is the main characteristic of inherited multisystem conditions with severe growth restriction. Nonetheless, the source of the originof these diseases are not completely investigated. Afore-mentioned afflictions are widespread among the population of Yakuts, located in the Republic of Sakha, which belongs to Russian Federation. Among the Yakuts, these conditions remarked by acute postnatal development hindrance, brachydactyly, optic atrophy (impairment of visual acuteness and color reflection), Pelger-Huet incongruity of WBCs and craniofacial dysmorphism but with average level of intelligence (1). Other features encompass chronic liver failure, underdeveloped cheekbones, loose skin, skeletal deformities and diminished tissue turgor (2). Purpose of Study. The overall objective of this research paper is to locate the gene that causes SOPH disorder. Methods The study uses secondary data from scientific journals published in authoritative databases, PubMed indexed in this case. The journal articles provide scientific investigations and information about the SOPH disease, NBAS gene and other relevant themes. A population sample of 129 individuals from five published research journals was considered. Results All reviewed researches were coherent in connecting SOPH syndrome with NBAS gene mutations

INVESTIGATING THE NATIONAL DIGITAL CADASTRAL DATABASE (NDCDB) DATA HANDLING WITHIN GIS APPLICATIONS

This paper explains the investigation carried out to understand NDCDB data handling within GIS applications. The method used was a case study replicated to five established GIS applications from different agencies, namely eKadasOnline, SKiP, iPlan, TM SmartMap and DBKL Interactive Portal. The case study was propositioned to the statements of; i) “Such methods of applying NDCDB are because user understands its characteristics”, and ii) “such methods of applying NDCDB are because users know how to adopt it.” Cross-case comparison analysis was then conducted to identify rival findings and explanation building. Based on the evidence of the multi-case study, it was concluded that such methods of adopting NDCDB by the GIS applications administrators and developers were because most of them have a partial understanding of the NDCDB characteristics which led to NDCDB being adopted based on the method that they think were suitable. Recommendations are highlighted in this paper to rectify knowledge-based mistakes found in this study, that included; i) ensuring the NDCDB’s cut-off-date; ii) utilises all existing NDCDB layers; iii) ensure to use the map projection parameters are the authorised and official value; iv) understand that the NDCDB utilises the GDM2000 datum with ITRF2000 epoch 2006; v) False Easting and North Easting can be discarded for geocentric datum; vi) adopting the built-in Geocentric Cassini map projection of GIS software is not advisable; and vii) obtaining relevant additional NDCDB layers. With the recommendations emplace, it is hoped the full potential of NDCDB can be tapped especially for multipurpose cadastre implementation including to ease spatial analysis. Data replication, exhaustion of resources, and reduce risks or costly investments made by decision makers, policy makers, developers or individuals can be avoided when NDCDB is fully optimised for spatial analysis

The Influence of Financial Knowledge, Financial Confidence, and Income on Financial Behavior Among the Workforce in Jakarta

. The purpose of this study is to analyze the influence of financial knowledge,financial confidence and income, on financial behavior. This research is based onTPB Model and Behavioral Finance Theory, and it was carried out based on thephenomenon that occur at present whereas the community is more focused on shorttermrather than on long-term. The Theory of Planned Behavior that rates theknowledge, self-confidence, and income becomes the basis of financial behavior ofindividuals, which become the topic of this research. The subjects in this study are thepeople of Jakarta Special Region, which includes the group of workforce who havealready had the job and fixed income every month. The results of this research showthat Financial Knowledge and Financial Confidence do affect Financial Behavior,whereas Income does not appear in the same way

Aerobic granulation for real domestic sewage treatment at hot and low humidity climate condition

With inoculum sludge from a conventional activated sludge wastewater treatment plant, a sequencing batch reactor fed with real domestic wastewater was operated at 50 ± 1 °C to study the formation of aerobic granular sludge (AGS) for simultaneous organics and nutrients removal with a complete cycle time of 3 h. The AGS were successfully cultivated with excellent settling ability and demonstrated exceptional performance in the organics and nutrients removal with influent loading rate of 1.2 kg COD m-3 d-1. Stable, regular, dense and fast settling granule (average diameter, 2.0 mm and sludge volume index, 73.501 mL g-1) were developed in a single reactor. In addition, 89 % COD removal efficiency was observed in the system at the maturation stage of the granulation, while its ammonia nitrogen removal efficiencies were up to 99 %. The study demonstrated the capabilities of AGS formation in a single, high and slender column type-bioreactor at high temperature which is suitable to be applied for hot climate and low humidity condition (e.g. Saudi Arabia)

IFRS Based Zakat Reporting: Adoption Rational Western Method Into Institutional Accountability

This study aims to evaluate the characteristics of zakat institution and proposes the adoption of International Financial Reporting Standard (IFRS) since it has developed and provides various product i.e zakat for productive purpose. This is important, considering that one of the measurement of accountability and transparency of an institution is providing brief financial report towards its beneficaries. Thereby, this study found that practically zakat institution is simillar to the SMEs, and there are 11 strandard of IFRS for SMEs that could be applicable to zakat institutionto achieve accountability and transparency. However, this study is preliminary study that proposes a conceptual frameworkwhich limited to the sharia compliance of IFRS that could be applicable to zakat Institution

Analyzing windstorm pattern in Malaysia based on extracted Twitter data.

Wind-rain interactions often lead to severe windstorm events and consequently cause damages and fatal destructions. The increase in frequency of recent windstorm events overwhelmed the nation. Thus, efforts in obtaining and recording these events are intensified with the help of current technology. This study aims to analyze the pattern of recent windstorm events by utilizing big data and GIS. In this study, the reported windstorm events in Twitter application were extracted using R-programming. Prior to analyses, the extracted data were screened to remove any outliers found. The extracted data were selected based on the credibility of its sources to ensure the accuracy and quality. These selected data were extracted from trusted users such as Meteorological Department of Malaysia (MMD), Berita Harian, Bernama and others. This study has demonstrated the possibility of Twitter data as an alternative data source in windstorm studies based on its reasonable findings. It is exhibited that there is drastic increased of windstorm events frequency in years 2018-2020, especially in the northern and west-coast regions of Peninsular. The highest frequency was recorded in April (inter-monsoon season) while the lowest is in February and December (northeast monsoon). The increase of frequency in several locations in the Peninsular is very alarming especially in the Klang Valley since this region is highly populated and serves as Malaysia's important economic zones. Hence, risk control should be considered in this region to reduce the negative impacts as suggested in SDG11 and SDG13

Soft Tissue Reconstruction following Hemipelvectomy: Eight-Year Experience and Literature Review

Background and Objectives. Hemipelvectomy is a major surgical procedure that associates with significant morbidity, functional impairment, and psychological and body image problem. Reconstruction of the defect is a challenged since a large amount of composite tissues are needed. We would like to share our eight-year experience with massive pelvic resection and reconstruction. Methods. A retrospective analysis of all cases of hemipelvectomy was conducted in our institution over eight-year period with particular attention given to the reconstruction choices and associated complications. Results. Thirteen patients were included with median age of 39 years (range 13–78) of which all had advanced tumour with stage IIb (54%) and Stage III (46%). External hemipelvectomy was performed in all cases, and resultant defects were reconstructed with variety type of flaps. These include fillet thigh flaps, regional pedicle flaps of different designs, and free flap. Conclusions. Massive pelvic tumour is rarely encountered in our population but can be seen across all age groups and usually due to late presentation. The defects should be reconstructed using local or regional flaps, incorporating the muscle component to enhance flap perfusion. The tissue should be harvested from the amputated limb, as it can limit the donor site morbidity

Development of Porous PCL Based Microcarrier

Polycaprolactone (PCL) has been used for cell cultivation due to its biocompatibility. PCL microcarrier featuring microporous structure were generated in the present study. PCL-based porous microcarrier was fabricated with different parameters by using emulsion evaporation method. From the study, size distribution of the microcarrier and the size of pore generated on microcarrier were affected by most of the parameters tested such as sterring speed, PVA concentration, camphene concentration, temperature and ratio between PCL and solvent.  Optimum pore size was generated at 20% camphene concentration with the average size of 11.74 µm which is conducive for cells to attached and populated well within the pores.  The surface properties of developed porous can be improved for potential application in cell culture research and development, as well as in tissue engineering