Effect of Metacognitive Skills Training on Metacognitive Awareness, Self-Efficacy and Academic Achievement of University Students

Aims: Metacognition deals with active monitoring and adjusting the results and cognitive processes to gain the purpose. Academic self-efficacy is dependent on students’ perception of learning and is an important factor in the success of students reasoning. This study aimed to determine the effectiveness of metacognitive skills training on metacognitive awareness, self-efficacy and academic achievement in university students. Materials & Methods: This semi-experimental study with a pretest-posttest controlled approach was conducted in all students of Kashan University of Medical Sciences in 2014. 50 participants were selected by cluster sampling and were randomly divided into 2 intervention and control groups. Metacognitive awareness of reading strategies inventory (MARSI) and General Self-efficacy Scale were used for data gathering. Data were analyzed using ANCOVA test. Findings: There were significant difference between the score of the pretest and posttest of the intervention group in both self-efficacy and metacognition awareness. In addition, there were significant differences between posttest scores of intervention and control groups in self-efficacy (p<0.001; F=42.46) and cognitive awareness (p<0.001; F=190.99), but there was no significant difference (p=0.072; F=3.39) in academic achievement between the intervention and control groups’ posttest scores. Conclusion: Metacognitive training affects metacognitive awareness and self-efficacy but it is not founded for academic achievement

Acid folic supplementation in major depressive disorder treatment: A double-blind randomized clinical trial

Background: Augmentation therapy involves the addition of a second drug, such as mood stabilizers, antipsychotics, and nutritional supplements, to a primary antidepressant treatment. Studies on adding folic acid to a preexisting antidepressive regimen as a form of augmentation therapy have had different and even controversial results. Objectives: This study aimed to determine the effects that adding folic acid to a pharmaceutical diet with citalopram has on the treatment of depression. Methods: This double-blind randomized clinical trial was conducted in Kashan, Iran on 90 patients who suffered from depression. Patients were allocated to study groups using random permuted blocks. One group (n=45) received a dosage of 20 mg citalopram in combination with 2.5mgfolic acid on a daily basis, and the other group (n=45) received the same daily dose of citalopram with a placebo for eight weeks. To measure the severity of each patient’s depression, the Beck depression inventory II (BDI-II) questionnaire was used prior to starting the antidepressant therapy and was repeated four, six, and eight weeks after beginning the treatment. A reduction from the original BDI-II scores that was greater than 50% was considered to be a response to treatment. Results: The average depression scores before treatment were 30.11±10.41 in the intervention group and 31.24±10.26 in the control group (P=0.6). At the end of the study, the depression scores in the intervention and the control groups were 13.31±6.57 and 19.11±8.59, respectively (P<0.001). A reduction in the average depression scores of the intervention group was statistically significant after six and eight weeks (P=0.01 and P=0.001, respectively). At the end of the study, the frequency of response to treatment was 73.3% in the intervention group and 40.0% in the control group (P<0.001). Conclusions: Folic acid, when used as a complementary therapy, can improve a patient’s response to antidepressants used for the treatment of major depression

Mindfulness Training and Quality of Life Among Pregnant Women: A Randomized Clinical Trial

quality of life (QOL). Objectives: The current study aimed to examine the effect of mindfulness training on QOL among pregnant females. Methods: In this clinical trial, 80 pregnant females eligible for inclusion were selected by convenience sampling method from Akramian, Taleghani and Ketabchi health centers in Kashan, Iran. The participants were randomly allocated into experimental and control groups (n = 40, each group) by block randomization method. Females in the experimental group received eight sessions of 90-minute mindfulness training, while females in the control group only received routine prenatal care services. Data were collected using a demographic questionnaire and a short-form 36 (SF-36) health survey questionnaire to measure the QOL. Chi-square, independent samples T-test and repeated measures analysis of variance were used to analyze the data. Results: The results showed that the totalQOLscore and subscales of emotional role functioning, vitality, mental health, social functioning and general health in the experimental group had significant changes compared to those of the control group. However, there was no significant difference between other subscales. The mean total QOL score before intervention was 44.84 � 4.44 and after intervention and follow-up was 50.42�3.71 and 49.42�5.24, respectively (P < 0.05). Conclusions: Mindfulness training can be used as a psychological prenatal care to moderate negative emotions, improve social functioning and cope with psychological and physical changes

Effect of lymphedema self-management group-based education compared with social network-based education on quality of life and fear of cancer recurrence in women with breast cancer: a randomized controlled clinical trial

Background: Breast cancer-related lymphedema (BCRL) and its associated symptoms harm the quality of life (QoL) of cancer survivors and can stimulate fear of cancer recurrence (FCR). Self-management education for lymphedema has been introduced as an effective method in controlling FCR. This study investigates the effect of lymphedema group-based education compared to the social network-based and control group on QoL and FCR in breast cancer patients. Methods: This three-arm clinical trial studied 105 patients with breast cancer-related lymphedema referred to SeyedKhandan rehabilitation center. Sampling was done by random allocation method in blocks of 3 with 35 subjects in each group. All subjects received routine lymphedema treatments. The group-based education (GE) and social network-based education (SNE) groups received self-management education in the clinic and Telegram� messenger channel, respectively. Impairment in QoL and mean score of FCR were assessed before, immediately after, and three months after the intervention by using the Persian version of Lymphedema Life Impact Scale (LLIS) and Fear of Progression Questionnaire-Short Form (FoPQ-SF), respectively. Mixed-model ANOVA was applied for statistical analysis. Results: There was a significant time effect on total LLIS (P = 0.007), psychosocial (P = 0.038) and functional (P = 0.024) subscale changes in three groups of study. Interaction between the main effect of group and time on psychosocial subscale changes was statistically significant (P = 0.017). The multicomparison results illustrated that the main effect of time, the main effect of group, and interaction of them on the mean score of FCR were P = 0.084, P = 0.380, and P = 0.568, respectively. Conclusion: Despite no significant reduction in the FCR score, results showed the improvement of most QoL aspects after three months of intervention. Although the social network-based education method was effective, the group-based education method was more beneficial. Applying these educational methods in lymphedema treatment protocols needs cost-effectiveness studies. Trial registration: This study was registered at the Iranian Registry of Clinical Trials (IRCT2017052834176N1). © 2020, The Author(s)

Effectiveness of acceptance and commitment therapy in cognitive emotion regulation strategies, headache-related disability, and headache intensity in patients with chronic daily headache

Background: Chronic daily headache is a serious disease, causing significant problems such as disability. It is characterized by pain localized to the head (headache) and headaches occurring on 15 or more days per month for more than 3 months (> 180 days per year). Programs for pain and health improvement in patients with painful diseases, such as headache, are not still fully developed. Acceptance and commitment therapy (ACT) is a new psychotherapy, which appears to be effective in the treatment of chronic pain. Objectives: This study aimed to examine the effectiveness of ACT in cognitive emotion regulation strategies, headache-related disability, and headache intensity in patients with chronic daily headaches. Methods: In the current study, a semi-experimental method was applied. The study was conducted at Shahid Beheshti Governmental hospital of Kashan, Iran in 2016. The sample consisted of 40 patients with chronic daily headache, who were selected via convenience sampling. The participants were randomly allocated into medical treatment as usual (MTAU) and ACT groups (20 samples per group) via block randomization. The ACT group received eight 90-minute weekly treatments, based on the ACT protocol. The cognitive emotion regulation questionnaire (CERQ), diary of headache severity, and headache-related disability inventory (HDI) were administered at pretreatment, posttreatment, and three-month follow-up in both groups. Results: In the current study, no significant differences were found between the groups in terms of demographic variables (P > 0.05). In the ACT group, the mean (SD) scores of emotional and functional aspects of headache disability were 26.87 ± 10.11 and 28.50 ± 9.04, respectively before the intervention, which decreased to 17.75 ± 8.32 and 18.12 ± 9.42 after the intervention and 21.37 ± 8.53 and 21.37 ± 9.87 in the follow-up, respectively (P 0.05). Conclusions: The results of the present study suggested that ACT is an effective treatment for reducing nonadjustment cognitive emotion regulation strategies, headache-related disability, and headache intensity and improving adjustment emotion regulation strategies in patients with chronic daily headache. © 2018, Iranian Red Crescent Medical Journal

Inflammatory responses bridge comorbid cardiac disorder in experimental model of IBD induced by DSS: protective effect of the trigonelline

Pathogenesis of the inflammatory bowel disease (IBD) involves the combination of immunological and inflammatory factors. IBD is associated with several extra-intestinal manifestations. The exact underlying bridge between the probable cardiac diseases in IBD patients is undetermined. Trigonelline is an alkaloid with several therapeutic potential properties. In this study, we aimed to assess the probable underlying mechanisms of this comorbidity as well as protective effect of trigonelline focusing inflammatory response and oxidative state in mouse model of colitis. Dextran sodium sulfate (DSS) was used for induction of colitis in mice. Trigonelline (10, 50 and 100 mg/kg) was administrated via intraperitoneal rout (i.p.) for 14 continuous days. Heart, intestine and serum samples were taken for assessment of total antioxidant capacity, malondialdehyde (MDA), gene expressions of inflammatory markers including tumor necrosis factor alpha (Tnf-α), interleukin 1-beta (Il/1β), toll- like receptor 4 (Tlr4) as well as for evaluation of histopathological alterations. Results demonstrated that trigonelline effectively attenuated the cellular/molecular and histopathological adverse effects of colitis in the intestine and heart tissues. In this regards, we found that trigonelline decreased the MDA level, attenuated the expression of Tnf-α, Il/1β and, Tlr4 as well as modulated the histopathological alterations in the intestine. Furthermore, trigonelline increased the antioxidant capacity in the related experimental groups. We concluded that IBD (colitis) is associated with comorbid cellular/molecular modifications in the heart and for the first time, we found that trigonelline has potential therapeutic effects (at least partially) to attenuate the cardiac manifestations of the colitis

The effects of crocin on psychological parameters in patients under methadone maintenance treatment: A randomized clinical trial

Background: Methadone maintenance treatment (MMT) might be associated with the symptoms of depression and anxiety, sleep disturbances and sexual dysfunctions. This study was designed to determine the effects of crocin on psychological parameters in patients under MMT. Methods: Patients under MMT were randomly allocated into two groups to receive either 30 mg/day crocin (2 plus crocin tablet, 15 mg BID) (n = 25) or placebo (2 tablets per day, 15 mg BID) (n = 25), one hour after taking food, for 8 weeks. Psychological parameters were evaluated at baseline and end of the trial to determine related associations between crocin and patients' mental health status. Results: After 8-week intervention, crocin significantly decreased Beck Depression Inventory (b - 6.66; 95 CI, - 9.88, - 3.45; P < 0.0001), Beck Anxiety Inventory (b - 4.35; 95 CI, - 5.94, - 2.75; P < 0.0001), general health questionnaire (b - 4.45; 95 CI, - 7.68, - 1.22; P = 0.008) and Pittsburgh Sleep Quality Index (b - 2.73; 95 CI, - 3.74, - 1.73; P < 0.0001) in patients under MMT, compared with the placebo. Crocin also significantly improved International Index of Erectile Functions (b 4.98; 95 CI, 2.08, 7.88; P = 0.001) rather than placebo. Conclusion: Our findings indicated that taking crocin for 8 weeks by patients under MMT had beneficial effects on their mental health status. Crocin can be recommended as an adjunct to methadone in opioid withdrawal protocols because of the ability to improve the quality of life and decrease opioids side effects in these patients. This trial was registered in the Iranian website for clinical trials registry as http://www.irct.ir: IRCT2017110537243N1. Clinical trial registration number: www.irct.ir: http://www.irct.ir: IRCT2017110537243N1. © 2019 The Author(s)

Exploring the Effects of Vitamin D Supplementation on Cognitive Functions and Mental Health Status in Subjects under Methadone Maintenance Treatment

Objectives:Vitamin D deficiency may be linked to several mental complications including cognitive deficits, depression, and anxiety in patients under methadone maintenance treatment (MMT). This study was designed to explore the effect of vitamin D supplementation on cognitive functions and mental health parameters in subjects under MMT.Methods:This randomized, double-blinded, placebo-controlled clinical trial was carried out among 64 patients under MMT. Participants were randomly allocated to receive either 50,000 IU vitamin D supplements (n=32) or placebo (n=32) every 2 weeks for 24 weeks. Cognitive functions and mental health parameters were taken at baseline and posttreatment to evaluate relevant variables.Results:After the 24-week intervention, compared with the placebo, serum 25(OH) vitamin D levels significantly increased in participants who received vitamin D supplements (β 14.50; 95 confidence interval CI, 13.17-15.83; P<0.001). In addition, compared with the placebo, subjects who received vitamin D had a significant reduction in Iowa Gambling Task (β-6.25; 95% CI,-8.60 to-3.90; P<0.001), and significant increases in Verbal Fluency Test (β 2.82; 95% CI, 0.78-4.86; P=0.007), Immediate Logic Memory (β 1. 32; 95% CI, 0.27-2.37; P=0.01), Reverse Digit Span (β 2.06; 95% CI, 1.18-2.94; P<0.001) and visual working memory (β 0.75; 95% CI, 0.33-1.16; P=0.001). Also, vitamin D supplementation significantly improved BDI (β-2.76; 95% CI,-3.97 to-1.55; P<0.001) compared with the placebo. When we applied Bonferroni correction, LM-Immediate (P=0.07) became nonsignificant, and other mental health parameters did not alter.Conclusions:Overall, taking 50,000 IU vitamin D supplements every 2 weeks for 24 weeks by patients under MMT had beneficial effects on cognitive functions and some mental health parameters. Further studies are needed to confirm our findings. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved

Non-thermal Radiation of Cosmological gamma-ray Bursters

We use 1+1/2 dimensional particle-in-cell plasma simulations to study the interaction of a relativistic, strongly magnetized wind with an ambient medium. Such an interaction is a plausible mechanism which leads to generation of cosmological gamma-ray bursts. We confirm the idea of Meszaros and Rees (1992) that an essential part (about 20%) of the energy that is lost by the wind in the process of its deceleration may be transferred to high-energy electrons and then to high-frequency (X-ray and gamma-ray) emission. We show that in the wind frame the spectrum of electrons which are accelerated at the wind front and move ahead of the front is nearly a two-dimensional relativistic Maxwellian with a relativistic temperature $T=6*10^9\Gamma_T$ K, where $\Gamma_T=200\Gamma_0$ with the accuracy of ~20%, and $\Gamma_0$ is the Lorentz factor of the wind, $\Gamma_0>100$ for winds outflowing from cosmological gamma-ray bursters. Our simulations point to an existence of a high-energy tail of accelerated electrons with a Lorentz factor of more than $700\Gamma_0$. Large-amplitude electromagnetic waves are generated by the oscillating currents at the wind front. The mean field of these waves ahead of the wind front is an order of magnitude less than the magnetic field of the wind. High-energy electrons which are accelerated at the wind front and injected into the region ahead of the front generate synchro-Compton radiation in the fields of large-amplitude electromagnetic waves. This radiation closely resembles synchrotron radiation and can reproduce the non-thermal radiation of gamma-ray bursts observed in the Ginga and BATSE ranges (from a few keV to a few MeV).Comment: 37 pages, 11 figures, submitted to Ap

Outward expansion of the lunar wake: ARTEMIS observations

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95030/1/grl29516.pd