41 research outputs found
The Serifos Metamorphic Core Complex (Greece) — kinematic investigations of the southern detachment mylonites
The island of Serifos is situated about
100km SSE of Athens in the Aegean
Sea and belongs to the Attic-Cycladic
massif. The geology of Serifos is largely
characterized by a shallow hornblendebiotite
granodiorite pluton that intruded
in the late Miocene into a previously
deformed (under blueschist conditions)
sequence mainly consisting of
ortho- and paragneisses, calc-silicate
marbles, amphibolites and schists. The
pluton has a dome-shaped body occupying
the central and southern parts of
the island (Salemink 1985). The Serifos
MCC is the very western continuation of a zone of syn- to post tectonic intrusions
younging from the East (Naxos,
Paros ?12Ma) to the West (Serifos 9–
8Ma). Whereas the older intrusions in
the East show a top to the North geometry,
the Serifos MCC has developed
a South-directed low-angle detachment
fault...conferenc
Extensional crustal-scale shear zones in the Western Cyclades (Kea, Greece)
Intense seismicity and intensely developed
active and ancient fault systems
are common to the Aegean Region. Extending/
thinning crust involves a complex
interplay of (1) Gulf of Corinth riftexpansion,
(2) west- and south-ward retreat
of the Hellenic Trench, (3) westward
impingement of the Anatolian
Platen, and/or (4) propagation of the
Anatolian Fault system into the Aegean.
New geological/structural investigations
on Kea (also known as Tzia), in
the Western Cyclades reveal a low angle
crustal-scale, detachment-type ductile
shear zone probably formed during
Miocene extension and thinning of the
continental crust...conferenc
Late stage evolution of the Serifos Metamorphic Core Complex (Cyclades, Greece)
The island of Serifos is located in
the Western Cyclades within the Attic-
Cycladic metamorphic belt. It represents
the westward continuation of an
arcuate belt of Metamorphic Core Complexes
with intrusions of late syn-post
tectonic intrusions younging from East
(e.g. Naxos main activity ca. 12Ma)
to West (e.g. Serifos with 9–8Ma). In
scientific discussions the dominance of
probably continuous extension since ca.
30Ma (e.g. Jolivet & Faccenna, 2000)
and the presence of Metamorphic Core
Complexes (Lister et al. 1984) is accepted.
The speculated roll-back of
the subducting plate possibly started
due to the slowing down of absolute
plate convergence rate between Africa
and Eurasia. This model is attractive,
because it would also explain the
shift from a compressional Andean-type
regime to an extensional Mariana-type
regime (Jolivet & Faccenna 2000). Contrary
to the kinematic directions reported
from the Central and Eastern
Cyclades, the movement of the hanging wall of the Serifos Metamorphic Core
Complex is south directed. The island’s
main part is occupied by an undeformed
granodiorite. Early granitic intrusions
intruded into low-grade M2-crystalline
rocks that have been overprinted to as
high as amphibolite facies conditions
due to contact metamorphism. Parts of
these rocks (gneisses and amphibolites)
as well as the early intrusions are deformed
to mylonites (Grasemann et al.
2004).conferenc
Geological and geomorphological analysis of Doren Landslide (Vorarlberg, Austria) based on high resolution UAV and TLS DTM
Myocardialis Infarctus Regiszter – 2010 : Tapasztalatok – első eredmények = Myocardial Infarction Registry – 2010. Feasibility and first results
A szerzĹ‘k ismertetik a 2010. január 1-jĂ©n megkezdett Infarctus Regiszter PilĂłta Vizsgálatot. A nemzetközileg elfogadott diagnosztikus kritĂ©riumokat alkalmazĂł Ă©s elĹ‘re meghatározott adatokra kiterjedĹ‘, prospektĂv, epidemiolĂłgiai adatgyűjtĂ©s hosszas Ă©s szĂ©les körű szakmai egyeztetĂ©se után indult el Budapest öt kerĂĽletĂ©ben Ă©s Szabolcs-Szatmár-Bereg megyĂ©ben. Budapesten öt szĂvkatĂ©teres centrumban Ă©s három – ilyen lehetĹ‘sĂ©ggel nem rendelkezĹ‘ – kardiolĂłgiai osztályon, Szabolcs-Szatmár-Bereg megyĂ©ben egy szĂvkatĂ©teres centrumban Ă©s három belgyĂłgyászati osztályon kezdĹ‘dött el a vizsgálat. A lakosok száma a szĂłban forgĂł terĂĽleten 997 324 fĹ‘. A vizsgálat megkezdĂ©sĂ©t követĹ‘en – a program fontosságát felismerve – további 16 centrum csatlakozott a vizsgálathoz. A program indulásátĂłl 2011. május 1-jĂ©ig 4293 beteg adatait rögzĂtettĂ©k. A regisztrált betegek 52,1%-ánál ST-eleváciĂłval járĂł (STEMI), 42,1%-ánál nem ST-eleváciĂłval járĂł myocardialis infarctust (NSTEMI), 3%-ánál instabil angina pectorist, 2,8%-ban egyĂ©b diagnĂłzist állapĂtottak meg a kĂłrházi elbocsátás idejĂ©n. A szerzĹ‘k vizsgálják a programba tartozĂł STEMI miatt kezelt betegek ellátásának jellemzĹ‘it Budapesten Ă©s Szabolcs-Szatmár-Bereg megyĂ©ben. A 301 budapesti beteg ellátásában öt, a 402 vidĂ©ki beteg ellátásában egy szĂvkatĂ©teres centrum vett rĂ©szt. A STEMI miatt kĂłrházba kerĂĽlt budapesti betegek 79,7%-a szĂvkatĂ©teres centrumba kerĂĽlt, Ă©s ezen betegek 84,6%-ánál intervenciĂł törtĂ©nt. Szabolcs-Szatmár-Bereg megyĂ©ben a STEMI miatt kezelt betegek 62,9%-a kerĂĽlt szĂvkatĂ©teres centrumba, Ă©s a betegek 77%-ánál törtĂ©nt katĂ©terterápiás beavatkozás. A 301 budapesti beteg esetĂ©n 8%-os, a 402 vidĂ©ki beteg esetĂ©n 10%-os kĂłrházi halálozást Ă©szleltek. A kĂłrházbĂłl eltávozott betegek esetĂ©n a szekunder prevenciĂł szempontjábĂłl fontos gyĂłgyszereket a Budapesten ellátott beteg esetĂ©n javasolták gyakrabban. A szerzĹ‘k megállapĂtják, hogy az egysĂ©ges diagnosztikus kritĂ©riumokat alkalmazĂł, prospektĂv adatgyűjtĂ©sen alapulĂł Infarctus Regiszter PilĂłta Vizsgálat kivihetĹ‘, az adatok nĂ©pegĂ©szsĂ©gĂĽgyi szempontbĂłl fontosak. A program országos bevezetĂ©se a finanszĂrozás során nyert adatoknál pontosabb kĂ©pet adhatna az infarktusos betegek ellátásának helyzetĂ©rĹ‘l. Orv. Hetil., 2011, 152, 1278–1283.
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Authors present the methodology and first data of Hungarian Myocardial Infarction Register Pilot Study started 1st of January, 2010. The aim of the study is to collect epidemiological data on myocardial infarction, to examine the natural history of the disease and to investigate the main characteristics on patient care in the pilot area. The program is using standardized diagnostic criteria and predefined electronic data record forms (eCRF). The pilot area consists of 5 districts in the capital, and Szabolcs-Szatmár-Bereg county. The area has 997 324 inhabitants. Eight cardiology departments, 5 with heart catheterization facility (C) in Budapest, four hospitals with one C in Szabolcs-Szatmar-Bereg county have been responsible of the patients’ care. After starting the program 16 other hospitals joined the program from different parts of Hungary. Between 1st of January 2010 and 1st of May 2011 4293 patients were registered, among them 52.1% with ST segment elevation myocardial infarction (STEMI), 42.1% with non-ST segment elevation myocardial infarction (NSTEMI), while 3% of the patients had unstable angina, and 2.8% of the cases had other diagnosis or the hospital diagnosis was missing in the eCRF. Authors compare the patients care with STEMI in five districts of Budapest and Szabolcs-Szatmár-Bereg county. In Budapest 79.7% of the 301 STEMI patients were treated in C and 84.6% of them were treated with primary percutaneous intervention (pPCI). In Szabolcs-Szatmár-Bereg county 402 patients were registered with STEMI, 62.9% of them were treated in C, where 77% of them were treated with pPCI. The drugs (beta blockers, ACE inhibitors, statins) important for secondary prevention were given more often to patients treated in the capital, however no difference was found in the platelet aggregation inhibitors therapy. Hospital mortality of STEMI patients was 8% in the capital, and 10% in Szabolcs- Szatmár-Bereg county. Authors conclude that the web based myocardial infarction register is feasible and important to have reliable data on patient care and a necessary quality control tool. Authors propose to broaden this pilot program and to start a nationwide myocardial infarction register. Orv. Hetil., 2011, 152, 1278–1283
Risk Related to Pre-Diabetes Mellitus and Diabetes Mellitus in Heart Failure With Reduced Ejection Fraction: Insights From Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure Trial
BACKGROUND: The prevalence of pre-diabetes mellitus and its consequences in patients with heart failure and reduced ejection fraction are not known. We investigated these in the Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure (PARADIGM-HF) trial. METHODS AND RESULTS: We examined clinical outcomes in 8399 patients with heart failure and reduced ejection fraction according to history of diabetes mellitus and glycemic status (baseline hemoglobin A1c [HbA1c]: /=6.5% [>/=48 mmol/mol; diabetes mellitus]), in Cox regression models adjusted for known predictors of poor outcome. Patients with a history of diabetes mellitus (n=2907 [35%]) had a higher risk of the primary composite outcome of heart failure hospitalization or cardiovascular mortality compared with those without a history of diabetes mellitus: adjusted hazard ratio, 1.38; 95% confidence interval, 1.25 to 1.52; P6.5%) and known diabetes mellitus compared with those with HbA1c<6.0% was 1.39 (1.17-1.64); P<0.001 and 1.64 (1.43-1.87); P<0.001, respectively. Patients with pre-diabetes mellitus were also at higher risk (hazard ratio, 1.27 [1.10-1.47]; P<0.001) compared with those with HbA1c<6.0%. The benefit of LCZ696 (sacubitril/valsartan) compared with enalapril was consistent across the range of HbA1c in the trial. CONCLUSIONS: In patients with heart failure and reduced ejection fraction, dysglycemia is common and pre-diabetes mellitus is associated with a higher risk of adverse cardiovascular outcomes (compared with patients with no diabetes mellitus and HbA1c <6.0%). LCZ696 was beneficial compared with enalapril, irrespective of glycemic status. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01035255
Angiotensin Receptor Neprilysin Inhibition Compared With Enalapril on the Risk of Clinical Progression in Surviving Patients With Heart Failure
BACKGROUND: -Clinical trials in heart failure have focused on the improvement in symptoms or decreases in the risk of death and other cardiovascular events. Little is known about the effect of drugs on the risk of clinical deterioration in surviving patients. METHODS AND RESULTS: -We compared the angiotensin-neprilysin inhibitor LCZ696 (400 mg daily) with the angiotensinconverting enzyme inhibitor enalapril (20 mg daily) in 8399 patients with heart failure and reduced ejection fraction in a double-blind trial. The analyses focused on prespecified measures of nonfatal clinical deterioration. In comparison with the enalapril group, fewer LCZ696-treated patients required intensification of medical treatment for heart failure (520 versus 604; hazard ratio, 0.84; 95% confidence interval, 0.74-0.94; P=0.003) or an emergency department visit for worsening heart failure (hazard ratio, 0.66; 95% confidence interval, 0.52-0.85; P=0.001). The patients in the LCZ696 group had 23% fewer hospitalizations for worsening heart failure (851 versus 1079; P<0.001) and were less likely to require intensive care (768 versus 879; 18% rate reduction, P=0.005), to receive intravenous positive inotropic agents (31% risk reduction, P<0.001), and to have implantation of a heart failure device or cardiac transplantation (22% risk reduction, P=0.07). The reduction in heart failure hospitalization with LCZ696 was evident within the first 30 days after randomization. Worsening of symptom scores in surviving patients was consistently more common in the enalapril group. LCZ696 led to an early and sustained reduction in biomarkers of myocardial wall stress and injury (N-terminal pro-Btype natriuretic peptide and troponin) versus enalapril. CONCLUSIONS: -Angiotensin-neprilysin inhibition prevents the clinical progression of surviving patients with heart failure more effectively than angiotensin-converting enzyme inhibition. Clinical Trial Registration-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01035255
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