Supersymmetric S-matrices from the worldsheet in 10 and 11d

We obtain compact formulae for tree super-amplitudes for 10 and 11-dimensional supergravity and 10-dimensional supersymmetric Yang-Mills and Born-Infeld. These are based on the \emph{polarised scattering equations}. These incorporate polarization data into a spinor field on the Riemann sphere and arise from a twistorial representation of ambitwistor strings in 10 and 11 dimensions. They naturally extend amplitude formulae to manifest maximal supersymmetry. The framework is the natural generalization of twistorial ambitwistor string formulae found previously in four and six dimensions and is informally motivated from a vertex operator prescription for a family of supersymmetric worldsheet ambitwistor string models.Comment: 7 page

The polarized scattering equations for 6d superamplitudes

We introduce a spinorial version of the scattering equations, the \emph{polarized scattering equations}, that incorporates spinor polarization data. They lead to new formulae for tree-level scattering amplitudes in six dimensions that directly extend to maximal supersymmetry. They give a quite distinct framework from that of Cachazo et al.; in particular, the formulae do not change character from even to odd numbers of particles. We find new ingredients for integrands for maximally supersymmetric Yang-Mills, gravity, M5 and D5 branes. We explain how the polarized scattering equations and supersymmetry representations arise from an ambitwistor-string with target given by a super-twistor description of the geometry of super-ambitwistor space for six dimensions. On reduction to four dimensions the polarized scattering equations give rise to massive analogues of the 4d refined scattering equations for amplitudes on the Coulomb branch. At zero mass this framework naturally generalizes the twistorial version of the ambitwistor string in four dimensions.Comment: 13 page

New Ambitwistor String Theories

We describe new ambitwistor string theories that give rise to the recent amplitude formulae for Einstein-Yang-Mills, (Dirac)-Born-Infeld, Galileons and others introduced by Cachazo, He and Yuan. In the case of the Einstein-Yang-Mills amplitudes, an important role is played by a novel worldsheet conformal field theory that provides the appropriate colour factors precisely without the spurious multitrace terms of earlier models that had to be ignored by hand. This is needed to obtain the correct multitrace terms that arise when Yang-Mills is coupled to gravity.Comment: 34 pages, 2 figures, 5 tables. v2: minor changes, published versio

Two-loop scattering amplitudes from the Riemann sphere

Financial support from EPSRC Grant No. EP/K032208/1 during the program GTA 2016. Y. G. is supported by the EPSRC Doctoral Prize Scheme EP/M508111/1, LJM by the EPSRC Grant No. EP/M018911/1, and the work of P. T. is supported by STFC Grant No. ST/L000385/1

Extracting regulator activity profiles by integration of de novo motifs and expression data: characterizing key regulators of nutrient depletion responses in Streptomyces coelicolor

Determining transcriptional regulator activities is a major focus of systems biology, providing key insight into regulatory mechanisms and co-regulators. For organisms such as Escherichia coli, transcriptional regulator binding site data can be integrated with expression data to infer transcriptional regulator activities. However, for most organisms there is only sparse data on their transcriptional regulators, while their associated binding motifs are largely unknown. Here, we address the challenge of inferring activities of unknown regulators by generating de novo (binding) motifs and integrating with expression data. We identify a number of key regulators active in the metabolic switch, including PhoP with its associated directed repeat PHO box, candidate motifs for two SARPs, a CRP family regulator, an iron response regulator and that for LexA. Experimental validation for some of our predictions was obtained using gel-shift assays. Our analysis is applicable to any organism for which there is a reasonable amount of complementary expression data and for which motifs (either over represented or evolutionary conserved) can be identified in the genome