The fingerprint of the summer 2018 drought in Europe on ground-based atmospheric CO2 measurements

During the summer of 2018, a widespread drought developed over Northern and Central Europe. The increase in temperature and the reduction of soil moisture have influenced carbon dioxide (CO2) exchange between the atmosphere and terrestrial ecosystems in various ways, such as a reduction of photosynthesis, changes in ecosystem respiration, or allowing more frequent fires. In this study, we characterize the resulting perturbation of the atmospheric CO2 seasonal cycles. 2018 has a good coverage of European regions affected by drought, allowing the investigation of how ecosystem flux anomalies impacted spatial CO2 gradients between stations. This density of stations is unprecedented compared to previous drought events in 2003 and 2015, particularly thanks to the deployment of the Integrated Carbon Observation System (ICOS) network of atmospheric greenhouse gas monitoring stations in recent years. Seasonal CO2 cycles from 48 European stations were available for 2017 and 2018.The UK sites were funded by the UK Department of Business, Energy and Industrial Strategy (formerly the Department of Energy and Climate Change) through contracts TRN1028/06/2015 and TRN1537/06/2018. The stations at the ClimaDat Network in Spain have received funding from the ‘la Caixa’ Foundation, under agreement 2010-002624

A simplified interventional mapping system (SIMS) for the selection of combinations of targeted treatments in non-small cell lung cancer

Non-small cell lung cancer (NSCLC) is a leading cause of death worldwide. Targeted monotherapies produce high regression rates, albeit for limited patient subgroups, who inevitably succumb. We present a novel strategy for identifying customized combinations of triplets of targeted agents, utilizing a simplified interventional mapping system (SIMS) that merges knowledge about existent drugs and their impact on the hallmarks of cancer. Based on interrogation of matched lung tumor and normal tissue using targeted genomic sequencing, copy number variation, transcriptomics, and miRNA expression, the activation status of 24 interventional nodes was elucidated. An algorithm was developed to create a scoring system that enables ranking of the activated interventional nodes for each patient. Based on the trends of co-activation at interventional points, combinations of drug triplets were defined in order to overcome resistance. This methodology will inform a prospective trial to be conducted by the WIN consortium, aiming to significantly impact survival in metastatic NSCLC and other malignancies

Institutions

Yver Jean. Institutions. In: Annales de Normandie. Bibliographie normande 1966. 1967. pp. 127-130

Institutions

Yver Jean. Institutions. In: Annales de Normandie, 10ᵉ année, n°2, 1960. Bibliographie normande 1959. pp. 20-24

Les deux groupes de Coutumes du Nord (Première partie)

Yver Jean. Les deux groupes de Coutumes du Nord (Première partie). In: Revue du Nord, tome 35, n°140, Octobre-décembre 1953. pp. 197-220

L'Université de Caen

Yver Jean. L'Université de Caen. In: Études Normandes, livraison 12, n°37, 3e trimestre 1954. L'Université de Caen. pp. 845-856

Institutions

Yver Jean. Institutions. In: Annales de Normandie. Bibliographie normande 1962. 1963. pp. 22-25

Les deux groupes de Coutumes du Nord (Deuxième partie)

Yver Jean. Les deux groupes de Coutumes du Nord (Deuxième partie). In: Revue du Nord, tome 36, n°141, Janvier-mars 1954. pp. 5-36

J.F. Lemarignier. — La France médiévale, institutions et société.

Yver Jean. J.F. Lemarignier. — La France médiévale, institutions et société.. In: Cahiers de civilisation médiévale, 14e année (n°56), Octobre-décembre 1971. pp. 387-389

Institutions

Yver Jean. Institutions. In: Annales de Normandie. Bibliographie normande 1971. 1972. pp. 363-368