Correlation Between Serum C-Reactive Protein And Cystatin C In Patients With Acute Cerebral Infarction And Carotid Artery Stenosis

To investigate the correlation between serum C-reactive protein (CRP) and serum cystatin C (Cys-C) levels in patients with acute cerebral infarction and carotid artery stenosis. Methods: From January 2015 to December 2016 admitted to our hospital new acute cerebral infarction parallel neck vascular color Doppler ultrasound examination showed 121 cases of carotid stenosis as the case group; select the same period of hospitalized patients with non-cerebrovascular disease in 50 cases As a control group. Fasting venous blood was collected on the third day after onset of the disease and serum levels of CRP and Cys-C were measured and compared. Results: Serum levels of CRP and Cys-C in case group were significantly higher than those in control group (P <0.05). The correlation between serum CRP and Cys-C was found in any pairwise comparison (r = 0.4732). The level of CRP and Cys-C were closely related to the degree of carotid artery stenosis (P <0.05). Conclusion: The combined detection of serum CRP and Cys-C levels can be used to evaluate the degree of carotid artery stenosis in patients with acute cerebral infarction and provide a reference for the next carotid endarterectomy

A three-dimensional actively spreading bone repair material based on cell spheroids can facilitate the preservation of tooth extraction sockets

Introduction: Achieving a successful reconstruction of alveolar bone morphology still remains a challenge because of the irregularity and complex microenvironment of tooth sockets. Biological materials including hydroxyapatite and collagen, are used for alveolar ridge preservation. However, the healing effect is often unsatisfactory.Methods: Inspired by superwetting biomimetic materials, we constructed a 3D actively-spreading bone repair material. It consisted of photocurable polyether F127 diacrylate hydrogel loaded with mixed spheroids of mesenchymal stem cells (MSCs) and vascular endothelial cells (ECs).Results: Biologically, cells in the spheroids were able to spread and migrate outwards, and possessed both osteogenic and angiogenic potential. Meanwhile, ECs also enhanced osteogenic differentiation of MSCs. Mechanically, the excellent physical properties of F127DA hydrogel ensured that it was able to be injected directly into the tooth socket and stabilized after light curing. In vivo experiments showed that MSC-EC-F127DA system promoted bone repair and preserved the shape of alveolar ridge within a short time duration.Discussion: In conclusion, the novel photocurable injectable MSC-EC-F127DA hydrogel system was able to achieve three-dimensional tissue infiltration, and exhibited much therapeutic potential for complex oral bone defects in the future

The Genetic Polymorphisms of HLA Are Strongly Correlated with the Disease Severity after Hantaan Virus Infection in the Chinese Han Population

The polymorphism of human leukocyte antigen (HLA), which is a genetic factor that influences the progression of hemorrhagic fever with renal syndrome (HFRS) after Hantaan virus (HTNV) infection, was incompletely understood. In this case-control study, 76 HFRS patients and 370 healthy controls of the Chinese Han population were typed for the HLA-A, -B, and -DRB1 loci. The general variation at the HLA-DRB1 locus was associated with the onset of HFRS (P<0.05). The increasing frequencies of HLA-DRB1*09 and HLA-B*46-DRB1*09 in HFRS patients were observed as reproducing a previous study. Moreover, the HLA-B*51-DRB1*09 was susceptible to HFRS (P=0.037; OR =3.62; 95% CI: 1.00–13.18). The increasing frequencies of HLA-B*46, HLA-B*46-DRB1*09, and HLA-B*51-DRB1*09 were observed almost in severe/critical HFRS patients. The mean level of maximum serum creatinine was higher in HLA-B*46-DRB1*09 (P=0.011), HLA-B*51-DRB1*09 (P=0.041), or HLA-B*46 (P=0.011) positive patients than that in the negative patients. These findings suggest that the allele HLA-B*46 and haplotypes HLA-B*46-DRB1*09 and HLA-B*51-DRB1*09 in patients could contribute to a more severe degree of HFRS and more serious kidney injury, which improve our understanding of the HLA polymorphism for a different outcome of HTNV infection

Human ACE2‑Functionalized Gold “Virus‑Trap” Nanostructures for Accurate Capture of SARS‑CoV‑2 and Single‑Virus SERS Detection

The current COVID-19 pandemic urges the extremely sensitive and prompt detection of SARS-CoV-2 virus. Here, we present a Human Angiotensin-converting-enzyme 2 (ACE2)-functionalized gold “virus traps” nanostructure as an extremely sensitive SERS biosensor, to selectively capture and rapidly detect S-protein expressed coronavirus, such as the current SARS-CoV-2 in the contaminated water, down to the single-virus level. Such a SERS sensor features extraordinary 106- fold virus enrichment originating from high-affinity of ACE2 with S protein as well as “virus-traps” composed of oblique gold nanoneedles, and 109- fold enhancement of Raman signals originating from multicomponent SERS effects. Furthermore, the identification standard of virus signals is established by machine-learning and identification techniques, resulting in an especially low detection limit of 80 copies mL− 1 for the simulated contaminated water by SARS-CoV-2 virus with complex circumstance as short as 5 min, which is of great significance for achieving real-time monitoring and early warning of coronavirus. Moreover, here-developed method can be used to establish the identification standard for future unknown coronavirus, and immediately enable extremely sensitive and rapid detection of novel virus

Chlorops

Key to species of Chlorops from Palearctic China 1. Ocellar triangle dark brown entirely....................................................................... 2 - Ocellar triangle yellow with black spot, or brown with yellow lateral margins or posterior corners...................... 3 2. Gena with a narrow black region on lower margin; scutum yellow entirely, covered with short setulae and pale pollen.............................................................................................. C. oralis (Duda) - Gena yellow entirely; scutum yellow, but brown posteriorly, shinning, covered with long setulae.... C. liupanshanus sp. nov. 3. 3 rd antennal segment enlarged, black, with a reddish spot basally; arista black, with black basal segment.................................................................................................. C. extraneus Wiedemann - 3 rd antennal segment or arista is different from mentioned above................................................ 4 4. Katepisternum with reddish-yellow lower portion............................................................ 5 - Katepisternum with black lower portion.................................................................... 6 5. Ocellar triangle brown, with yellow lateral margins and posterior margin, with a black medial sulcus and a yellow sulcus on each lateral margin, and also with a yellow spot on each lateral margin of ocellar tubercle; scutum with 5 black stripes........................................................................................... C. trisetifer sp. nov. - Ocellar triangle yellow, with a small black spot on anterior apex, and with a medial brownish bridge; scutum yellow with 5 reddish-yellow stripes, the median stripe black anteriorly...................................... C.rufinus Zetterstedt 6. Ocellar triangle yellow, with a black spot in leaf shape covering most part of triangle and contended with ocellar tubercle, and with a medial sulcus attending to anterior margin of frons, yellow anteriorly and black posteriorly; anepisternum covered with tiny yellow setulae.................................................................... C. flavipalpus sp. nov. - Ocellar triangle different from mentioned above; anepisternum bare............................................. 7 7. Ocellar triangle yellow, main portion of triangle only two-thirds as long as frons, with a brown spot on anterior apex, and also with a medial black sulcus from ocellar tubercle to anterior margin of frons; 3 rd antennal segment black..................................................................................................... C. gansuensis sp. nov. - Ocellar triangle yellow, main portion of triangle nearly attending to anterior margin of frons, dark brown centrally in leaf shape contended with ocellar tubercle, with a medial black sulcus and a yellow spot on each lateral margin of ocellar tubercle; 3 rd antennal segment brownish dorsally and distally, yellow ventrally and basally................... C. xinjiangensis sp. nov.Published as part of Cui, Yusi & Yang, Ding, 2011, Species of Chlorops Meigen from Palaearctic China (Diptera, Chloropidae), pp. 18-30 in Zootaxa 2987 on page 19, DOI: 10.5281/zenodo.20451

Chlorops extraneus Wiedemann

Chlorops extraneus Wiedemann Chlorops extraneus Wiedemann, 1830. Aussereurop. zweifl. Insekt., 2: 596. Type locality: China. Diagnosis. Ocellar triangle yellow with a medial black spot; 3 rd antennal segment enlarged, black, with a reddish spot basally; arista black, with black basal segment. Distribution. China.Published as part of Cui, Yusi & Yang, Ding, 2011, Species of Chlorops Meigen from Palaearctic China (Diptera, Chloropidae), pp. 18-30 in Zootaxa 2987 on page 29, DOI: 10.5281/zenodo.20451

Epichlorops puncticollis Zetterstedt

Epichlorops puncticollis (Zetterstedt) (Figs. 10–18) Oscinis puncticollis Zetterstedt, 1848: 2636. Type locality: SWEDEN: Gotland, Gudhem. Epichlorops puncticollis: Becker 1912: 28; Sabrosky 1941: 742; Sabrosky 1965: 791; Andersson 1966: 70; Andersson 1977: 145; Kanmiya 1983: 292; Wheeler 1994: 407. Diagnosis. Head slightly longer than high in profile. Frons nearly as wide as long, projecting only slightly in front of eye. Ocellar triangle dark brown, narrowing evenly to anterior margin of frons, anterior apex ending in a broad obtuse tip. 3 rd antennal segment brown. Thorax slightly broader than head. Scutum black except for yellow lateral margins and covered with fine black setulae on small tubercles. Scutellum yellow. Abdomen completely brown dorsally except for posterior margin yellow, setulae on tergum 5 pale. Male genitalia: epandrium with pale setulae; surstylus with posterior region short hook-like and curved forward; hypandrium relatively narrow in lateral view. Material examined. 1 male, CHINA: Xinjiang, Aletai, Beitun, 21. VII. 2007, Shan Huo; 5 males 2 females, CHINA: Xinjiang, Aletai, Hemu, 22. VII. 2007, Shan Huo; 1 male, CHINA: Xinjiang, Aletai, Hemu, 24. VII. 2007, Shan Huo. Distribution. Canada, China (Xinjiang), France, Germany, Great Britain, Japan, Kazakhstan, Mexico, Poland, Russia, USA.Published as part of Cui, Yusi & Yang, Ding, 2009, Species of Epichlorops Becker from China (Diptera, Chloropidae), pp. 41-46 in Zootaxa 2017 on page 45, DOI: 10.5281/zenodo.18600