Pré-natal durante a pandemia de COVID-19: uma análise dos indicadores do Previne Brasil e sua influência na incidência de sífilis congênita e em gestantes

Introdução: O Previne Brasil reestruturou a forma de financiamento do Sistema Único de Saúde, estabelecendo metas e indicadores cujo objetivo é garantir a qualidade da assistência. Três destes novos indicadores dizem respeito ao pré-natal. Objetivo: Avaliar a qualidade das atividades de pré-natal prestadas às gestantes no município de Campina Grande (PB) entre os anos de 2018 e 2021, por meio dos indicadores do Previne Brasil, estabelecendo um comparativo entre os anos de pandemia de COVID-19 e relacionando os com a incidência de casos de sífilis congênita e em gestantes. Método: Trata-se de um estudo ecológico, observacional e descritivo realizado por meio da coleta de dados secundários do Sistema de Informação em Saúde para a Atenção Básica (2018–2021) de indicadores de desempenho do programa Previne Brasil para o pré-natal: proporção de gestantes com pelo menos seis consultas de pré-natal; proporção de gestantes com realização de exames para sífilis e HIV e a proporção de gestantes que passaram por atendimento odontológico. Acrescentou-se ainda uma busca de novos casos de sífilis congênita e em gestantes no TABNET - Sistema de Informação de Agravos de Notificação (Sinan) abrangendo os mesmos anos. Resultados: O indicador com piores resultados foi o de atendimento odontológico. Para os demais, embora haja entre um quadrimestre e outro, alguma variação de melhoria, os três indicadores avaliados apresentaram resultados muito aquém da meta de 60% estabelecida pelo Ministério da Saúde, o que pode ter influenciado no aumento considerável da incidência de sífilis no ano de 2021. Conclusões: É preciso que se estabeleça formas efetivas de melhoria da assistência que culminem em uma atenção integral à saúde da gestante que promovam desde o pré-natal a saúde do bebê. Para além disso, faz-se necessário o estudo das barreiras que separam a gestante do atendimento odontológico, desmistificando a relação que se estabelece entre a gestação e a atenção à saúde bucal

Factors Associated with Hyposalivation in Brazilian Adults

Objective: To determine the occurrence of hyposalivation in Brazilian adults and its association with individual determinants, such as the use of medications, systemic conditions, smoking, and alcohol consumption. Material and Methods: A cross-sectional study with 402 adults was developed. Information was collected on sociodemographic and general health characteristics, and sialometry was performed with stimulated salivary flow. It indicated low salivary flow when ≤ 0.7 mL/min. Bivariate and multivariate analyses were conducted using a decision tree (p<0.05). Results: The sample was comprised predominantly of women (68.2%) aged ≤ 29 years (25.4%). Most participants did not use medication (56.7%). Among systemic diseases, the most cited was hypertension (25.1%). More than a third of the participants presented hyposalivation (40.3%), being associated with the following variables: age between 50 to 59 years (p=0.011), female sex (p<0.001), menopause (p=0.001), use of alcohol (p=0.033), systemic disease (p=0.002) and medication use (p<0.001). In multivariate analysis, in addition to sex (p<0.001) and hypertension (p=0.005), an association was also found between hyposalivation and diabetes (p=0.014). Conclusion: Factors associated with hyposalivation in adults were sex and the presence of hypertension or diabetes

Factors Associated with Hyposalivation in Brazilian Adults

Objective: To determine the occurrence of hyposalivation in Brazilian adults and its association with individual determinants, such as the use of medications, systemic conditions, smoking, and alcohol consumption. Material and Methods: A cross-sectional study with 402 adults was developed. Information was collected on sociodemographic and general health characteristics, and sialometry was performed with stimulated salivary flow. It indicated low salivary flow when ≤ 0.7 mL/min. Bivariate and multivariate analyses were conducted using a decision tree (p<0.05). Results: The sample was comprised predominantly of women (68.2%) aged ≤ 29 years (25.4%). Most participants did not use medication (56.7%). Among systemic diseases, the most cited was hypertension (25.1%). More than a third of the participants presented hyposalivation (40.3%), being associated with the following variables: age between 50 to 59 years (p=0.011), female sex (p<0.001), menopause (p=0.001), use of alcohol (p=0.033), systemic disease (p=0.002) and medication use (p<0.001). In multivariate analysis, in addition to sex (p<0.001) and hypertension (p=0.005), an association was also found between hyposalivation and diabetes (p=0.014). Conclusion: Factors associated with hyposalivation in adults were sex and the presence of hypertension or diabetes

New Pregnane Glycosides from <i>Mandevilla dardanoi</i> and Their Anti-Inflammatory Activity

Mandevilla Lindl. is an important genus of the Apocynaceae family, not only as ornamental plants but also for its medicinal uses. In Brazil, Mandevilla species are indicated to treat asthma and skin infections, their anti-inflammatory potential and wound healing properties are also reported in the literature. Concerning their chemical composition, this group of plants is a conspicuous producer of pregnane glycosides. Mandevilla dardanoi is an endemic species from the Brazilian semiarid region not studied by any phytochemical methods. In view of the medicinal potential of Mandevilla species, this study aimed to isolate new pregnane glycosides from M. dardanoi. To achieve this main goal, modern chromatography techniques were employed. Five new pregnane glycosides, dardanols A-E, were isolated from the roots of M. dardanoi by HPLC. Their structures were determined using extensive 1D and 2D-NMR and mass spectrometry (MSn and HRESIMS) data. The cytotoxicity and the anti-inflammatory potential of these compounds were evaluated. The first was evaluated by measuring proinflammatory cytokines and nitric oxide production by stimulated macrophages. Dardanols were able to inhibit the production of nitric oxide and reduce IL-1β and TNF-α. The current work demonstrates the chemodiversity of Brazilian semiarid species and contributes to amplifying knowledge about the biological potential of the Mandevilla genus

Comenta&#769;rios a uma sentenc&#807;a anunciada : o processo Lula

“Comentários a uma sentença: o Caso Lula” é talvez o mais importante documento jurídico publicado no Brasil em décadas. A presente coletânea de artigos nasceu de um movimento espontâneo e bastante significativo de juristas brasileiros e estrangeiros que examinaram cuidadosamente a sentença proferida no âmbito do processo que tramitou na 13ª Vara Federal de Curitiba, no caso que ficou conhecido na mídia como o do “tríplex do Guarujá”. <br>De la presentación de Geraldo Prad

Comentarios a una sentencia anunciada : el proceso Lula

El centenar de textos que conforman este libro -escritos por un movimiento de prestigiosos/as juristas y abogados- desgranan el procedimiento al que fue sometido Lula. En la opinión de las y los autores de los artículos las normas no fueron observadas, y su inobservancia llevó a que se dictaminase una decisión injusta. Frases del estilo "Voy a tomar una decisión revolucionaria, dejando de lado la ley, porque por la ley no se puede condenarlo de ninguna manera”, dichas en los juicios por las más altas autoridades judiciales militares y civiles, hoy son conocidas gracias a quienes se abocaron al trabajo de escuchar los audios de aquellas sesiones, nutriendo las reflexiones que argumentan sobre el imperativo de la hora: restablecer el estado de derecho y absolver al presidente Lula Da Silva