Pengembangan Media Pembelajaran Fisika Berupa Buletin Dalam Bentuk Buku Saku Untuk Pembelajaran Fisikakelas VIII Materi Gaya Ditinjau Dari Minat Baca Siswa

Tujuan dari penelitian ini untuk mengembangkan media pembelajaran berupa buletin dalam bentuk buku saku untuk pembelajaran Fisika kelas VIII pada materi Gaya ditinjau dari aspek materi, konstruk, dan bahasa serta minat baca siswa. Penelitian ini termasuk penelitian pengembangan yang menggunakan metode Research and Development (R&D). Penelitian ini menggunakan model pengembangan model prosedural yaitu model yang bersifat deskriptif yang menunjukkan tahapan-tahapan yang harus diikuti untuk menghasilkan produk berupa media pembelajaran.Jenis data yang diperoleh bersifat kualitatif dan kuantitatif yaitu angket dan wawancara. Teknik analisis data yang digunakan adalah analisis deskriptif kualitatif dan kuantitatif. Hasil penelitian menunjukkan bahwa media pembelajaran yang dikembangkan berupa buletin Fisika dalam bentuk buku saku memiliki kriteria sangat baik berdasarkan penilaian dari ahli materi, ahli bahasa Indonesia, dan ahli media memberikan rata-rata penilaian sebesar 86,56%. Media pembelajaran yang dikembangkan juga memiliki kriteria sangat baik bila ditinjau dari peningkatan minat baca siswa. Hal ini terbukti pada hasil angket minat baca awal dan akhir yang diberikan kepada siswa yang memberikan rata-rata peningkatan sebesar 11,13%. Selain itu juga dianalisis dengan menggunakan uji-t berpasangan terhadap data masing-masing kelompok uji coba untuk mengetahui signifikansi dari peningkatan minat baca siswa. Untuk uji coba perorangan diperoleh hasil perhitungan thitung = 6,957 > ttabel = 1,943 dan nilai Sig. = 0,001 < 0,05 yang berarti sangat signifikan. Untuk kelompok kecil didapatkan hasil perhitungan bahwa thitung = 7,848 > ttabel = 1,725 dan nilai Sig. = 0,000 < 0,05 yang berarti sangat signifikan. Untuk kelompok besar juga didapatkan hasil perhitungan bahwa thitung = 20,214 > ttabel = 1,725 dan nilai Sig. = 0,000 < 0,05 yang berarti sangat signifikan. Simpulan dari penelitian ini adalah media pembelajaran berupa buletin dalam bentuk buku saku memiliki kriteria sangat baik bila ditinjau dari aspek materi, konstruk, dan bahasa serta minat baca siswa

Konzeption und Prototypentwicklung zur automatisierten Bestellauslösung

The aim of this thesis was to design a new software solution called BoxControl 2.0 and to implement a working prototype. First, the workflow and the current RFID-based process flow within the Würth Industry Service were briefly introduced. Then the current software, hardware and changes to the prevailing circumstances were presented. In order to work out a best practice approach, related work on RFID middleware were carefully examined after that. The work also includes requirements engineering and design for a cross-platform system that implied a backend in combination with two different interfaces, a common frontend, a monitoring and a remote access concept etc. Ideas and designs derived from the analysis were implemented as a prototype in Java and JavaScript. Different problems, which have occurred during the implementation, and their solutions were shown. At the end, the requirements were compared with the actual state of the implementation. The prototype was running fine. Although it did not meet all the defined requirements due to steep learning curve and great effort that was spent implementing the substantial functions, the remaining functions can be achieved with little effort after the project. Consequently, a very good basis for further development of BoxControl 2.0 was created

DataSheet_1_MLXIPL associated with tumor-infiltrating CD8+ T cells is involved in poor prostate cancer prognosis.docx

IntroductionWithin tumor microenvironment, the presence of preexisting antitumor CD8+ T Q7 cells have been shown to be associated with a favorable prognosis in most solid cancers. However, in the case of prostate cancer (PCa), they have been linked to a negative impact on prognosis.MethodsTo gain a deeper understanding of the contribution of infiltrating CD8+ T cells to poor prognosis in PCa, the infiltration levelsof CD8+ T cells were estimated using the TCGA PRAD (The Cancer Genome Atlas Prostate Adenocarcinoma dataset) and MSKCC (Memorial Sloan Kettering Cancer Center) cohorts.ResultsBioinformatic analyses revealed that CD8+ T cells likely influence PCa prognosis through increased expression of immune checkpoint molecules and enhanced recruitment of regulatory T cells. The MLXIPL was identified as the gene expressed in response to CD8+ T cell infiltration and was found to be associated with PCa prognosis. The prognostic role of MLXIPL was examined in two cohorts: TCGA PRAD (p = 2.3E-02) and the MSKCC cohort (p = 1.6E-02). Subsequently, MLXIPL was confirmed to be associated with an unfavorable prognosis in PCa, as evidenced by an independent cohort study (hazard ratio [HR] = 2.57, 95% CI: 1.42- 4.65, p = 1.76E-03).DiscussionIn summary, the findings suggested that MLXIPL related to tumor-infiltrating CD8+ T cells facilitated a poor prognosis in PCa.</p

LncRNA MT1JP functions as a ceRNA in regulating FBXW7 through competitively binding to miR-92a-3p in gastric cancer

Abstract Background Emerging evidence has shown that dysregulation function of long non-coding RNAs (lncRNAs) implicated in gastric cancer (GC). However, the role of the differentially expressed lncRNAs in GC has not fully explained. Methods LncRNA expression profiles were determined by lncRNA microarray in five pairs of normal and GC tissues, further validated in another 75 paired tissues by quantitative real-time PCR (qRT-PCR). Overexpression of lncRNA MT1JP was conducted to assess the effect of MT1JP in vitro and in vivo. The biological functions were demonstrated by luciferase reporter assay, western blotting and rescue experiments. Results LncRNA MT1JP was significantly lower in GC tissues than adjacent normal tissues, and higher MT1JP was remarkably related to lymph node metastasis and advance stage. Besides, GC patients with higher MT1JP expression had a well survival. Functionally, overexpression of lncRNA MT1JP inhibited cell proliferation, migration, invasion and promoted cell apoptosis in vitro, and inhibited tumor growth and metastasis in vivo. Functional analysis showed that lncRNA MT1JP regulated FBXW7 expression by competitively binding to miR-92a-3p. MiR-92a-3p and down-regulated FBXW7 reversed cell phenotypes caused by lncRNA MT1JP by rescue analysis. Conclusion MT1JP, a down-regulated lncRNA in GC, was associated with malignant tumor phenotypes and survival of GC. MT1JP regulated the progression of GC by functioning as a competing endogenous RNA (ceRNA) to competitively bind to miR-92a-3p and regulate FBXW7 expression. Our study provided new insight into the post-transcriptional regulation mechanism of lncRNA MT1JP, and suggested that MT1JP may act as a potential therapeutic target and prognosis biomarker for GC

Additional file 2: of KCNMA1 cooperating with PTK2 is a novel tumor suppressor in gastric cancer and is associated with disease outcome

Supplementary materials. (PDF 82 kb

Additional file 1: of LncRNA MT1JP functions as a ceRNA in regulating FBXW7 through competitively binding to miR-92a-3p in gastric cancer

Figure S1-S10 (Online). Table S1. The top 10 significantly upregulated and downregulated lncRNAs identified by Arraystar Human lncRNA/mRNA chip. Table S2. The prime sequences of target genes used in real-time PCR. (DOCX 1257 kb