A knee-point-based evolutionary algorithm using weighted subpopulation for many-objective optimization

The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.Among many-objective optimization problems (MaOPs), the proportion of nondominated solutions is too large to distinguish among different solutions, which is a great obstacle in the process of solving MaOPs. Thus, this paper proposes an algorithm which uses a weighted subpopulation knee point. The weight is used to divide the whole population into a number of subpopulations, and the knee point of each subpopulation guides other solutions to search. Besides, Additionally, the convergence of the knee point approach can be exploited, and the subpopulation-based approach improves performance by improving the diversity of the evolutionary algorithm. Therefore, these advantages can make the algorithm suitable for solving MaOPs. Experimental results show that the proposed algorithm performs better on most test problems than six other state-of-the-art many-objective evolutionary algorithms

Adaptive neighborhood selection for many-objective optimization problems

The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI linkIt is generally accepted that conflicts between convergence and distribution deteriorate with an increase in the number of objectives. Furthermore, Pareto dominance loses its effectiveness in many-objectives optimization problems (MaOPs), which have more than three objectives. Therefore, a more valid selection method is needed to balance convergence and distribution. This paper presents a many-objective evolutionary algorithm, called Adaptive Neighborhood Selection for Many-objective evolutionary algorithm(ANS-MOEA), to deal with MaOPs. This method defines the performance of each individual by two types of information, convergence information (CI) and distribution information (DI). In the critical layer, a well-converged individual is selected first from the population, and its neighbors, calculated by DI, are pushed into neighbor collection (NC) soon afterwards. Then, the proper distribution of the population is ensured by competition individuals with large DI go back to the population and individuals with small DI remain in the collection. Four state-of-the-art MaOEAs are selected as the competitive algorithms to validate ANS-MOEA. The experimental results show that ANS-MOEA can solve a MaOP and generate a set of remarkable solutions to balance convergence and distribution

Anisotropic, Intermediate Coupling Superconductivity in Cu0.03TaS2

The anisotropic superconducting state properties in Cu0.03TaS2 have been investigated by magnetization, magnetoresistance, and specific heat measurements. It clearly shows that Cu0.03TaS2 undergoes a superconducting transition at TC = 4.03 K. The obtained superconducting parameters demonstrate that Cu0.03TaS2 is an anisotropic type-II superconductor. Combining specific heat jump = 1.6(4), gap ratio 2/kBTC = 4.0(9) and the estimated electron-phonon coupling constant ~ 0.68, the superconductivity in Cu0.03TaS2 is explained within the intermediate coupling BCS scenario. First-principles electronic structure calculations suggest that copper intercalation of 2H-TaS2 causes a considerable increase of the Fermi surface volume and the carrier density, which suppresses the CDW fluctuation and favors the raise of TC.Comment: 16pages, 5figure

Gallnut tannic acid alleviates gut damage induced by Salmonella pullorum in broilers by enhancing barrier function and modulating microbiota

Pullorum disease (PD) is a bacterial infection caused by Salmonella pullorum (S. pullorum) that affects poultry. It is highly infectious and often fatal. Antibiotics are currently the mainstay of prophylactic and therapeutic treatments for PD, but their use can lead to the development of resistance in pathogenic bacteria and disruption of the host's intestinal flora. We added neomycin sulfate and different doses of tannic acid (TA) to the drinking water of chicks at 3 days of age and infected them with PD by intraperitoneal injection of S. pullorum at 9 days of age. We analyzed intestinal histopathological changes and the expression of immune-related genes and proteins by using the plate smear method, histological staining, real-time fluorescence quantitative PCR, ELISA kits, and 16S rRNA Analysis of intestinal flora. The results demonstrate that S. pullorum induces alterations in the immune status and impairs the functionality of the liver and intestinal barrier. We found that tannic acid significantly ameliorated S. pullorum-induced liver and intestinal damage, protected the intestinal physical and chemical barriers, restored the intestinal immune barrier function, and regulated the intestinal flora. Our results showed that TA has good anti-diarrhoeal, growth-promoting, immune-regulating, intestinal barrier-protecting and intestinal flora-balancing effects, and the best effect was achieved at an additive dose of 0.2%

Enhancement of Low-field Magnetoresistance in Self-Assembled Epitaxial La0.67Ca0.33MnO3:NiO and La0.67Ca0.33MnO3:Co3O4 Composite Films via Polymer-Assisted Deposition

Polymer-assisted deposition method has been used to fabricate self-assembled epitaxial La(0.67)Ca(0.33)MnO(3):NiO and La(0.67)Ca(0.33)MnO(3):Co(3)O(4) films on LaAlO(3) substrates. Compared to pulsed-laser deposition method, polymer-assisted deposition provides a simpler and lower-cost approach to self-assembled composite films with enhanced low-field magnetoresistance effect. After the addition of NiO or Co(3)O(4), triangular NiO and tetrahedral Co(3)O(4) nanoparticles remain on the surface of La(0.67)Ca(0.33)MnO(3) films. This results in a dramatic increase in resistivity of the films from 0.0061 Ω•cm to 0.59 Ω•cm and 1.07 Ω•cm, and a decrease in metal-insulator transition temperature from 270 K to 180 K and 172 K by the addition of 10%-NiO and 10%-Co(3)O(4), respectively. Accordingly, the maximum absolute magnetoresistance value is improved from −44.6% to −59.1% and −52.7% by the addition of 10%-NiO and 10%-Co(3)O(4), respectively. The enhanced low-field magnetoresistance property is ascribed to the introduced insulating phase at the grain boundaries. The magnetism is found to be more suppressed for the La(0.67)Ca(0.33)MnO(3):Co(3)O(4) composite films than the La(0.67)Ca(0.33)MnO(3):NiO films, which can be attributed to the antiferromagnetic properties of the Co(3)O(4) phase. The solution-processed composite films show enhanced low-field magnetoresistance effect which are crucial in practical applications. We expect our polymer-assisted deposited films paving the pathway in the field of hole-doped perovskites with their intrinsic colossal magnetoresistance

Abnormal Degree Centrality Associated With Cognitive Dysfunctions in Early Bipolar Disorder

Delayed diagnosis of bipolar disorder (BD) is common. However, diagnostic validity may be enhanced using reliable neurobiological markers for BD. Degree centrality (DC) is one such potential marker that enables researchers to visualize neuronal network abnormalities in the early stages of some neuropsychiatric disorders. In the present study, we measured resting-state DC abnormalities and cognitive deficits in order to identify early neurobiological markers for BD. We recruited 23 patients with BD who had recently experienced manic episodes (duration of illness <2 years) and 46 matched healthy controls. Our findings indicated that patients with BD exhibited DC abnormalities in frontal areas, temporal areas, the right postcentral gyrus, and the posterior lobe of the cerebellum. Moreover, correlation analysis revealed that psychomotor speed indicators were associated with DC in the superior temporal and inferior temporal gyri, while attention indicators were associated with DC in the inferior temporal gyrus, in patients with early BD. Our findings suggest that DC abnormalities in neural emotion regulation circuits are present in patients with early BD, and that correlations between attention/psychomotor speed deficits and temporal DC abnormalities may represent early markers of BD

Identification of Novel Biallelic TLE6 Variants in Female Infertility With Preimplantation Embryonic Lethality

Preimplantation embryonic lethality is a rare cause of primary female infertility. It has been reported that variants in the transducin-like enhancer of split 6 (TLE6) gene can lead to preimplantation embryonic lethality. However, the incidence of TLE6 variants in patients with preimplantation embryonic lethality is not fully understood. In this study, we identified four patients carrying novel biallelic TLE6 variants in a cohort of 28 patients with preimplantation embryonic lethality by whole-exome sequencing and bioinformatics analysis, accounting for 14.29% (4/28) of the cohort. Immunofluorescence showed that the TLE6 levels in oocytes from patients were much lower than in normal control oocytes, suggesting that the variants result in the lower expression of the TLE6 protein in oocytes. In addition, a retrospective analysis showed that the four patients underwent a total of nine failures of in vitro fertilization and intracytoplasmic sperm injection attempts, and one of them became pregnant on the first attempt using donated oocytes. Our study extends the genetic spectrum of female infertility caused by variants in TLE6 and further confirms previously reported findings that TLE6 plays an essential role in early embryonic development. In such case, oocyte donation may be the preferred treatment

HSA: integrating multi-track Hi-C data for genome-scale reconstruction of 3D chromatin structure

Genome-wide 3C technologies (Hi-C) are being increasingly employed to study three-dimensional (3D) genome conformations. Existing computational approaches are unable to integrate accumulating data to facilitate studying 3D chromatin structure and function. We present HSA (http://ouyanglab.jax.org/hsa/), a flexible tool that jointly analyzes multiple contact maps to infer 3D chromatin structure at the genome scale. HSA globally searches the latent structure underlying different cleavage footprints. Its robustness and accuracy outperform or rival existing tools on extensive simulations and orthogonal experiment validations. Applying HSA to recent in situ Hi-C data, we found the 3D chromatin structures are highly conserved across various human cell types. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13059-016-0896-1) contains supplementary material, which is available to authorized users