Estrogenic Effects of Tapak Dara (Catharantus roseus) Leaf Methanol Extract on The Estrus Cycle of Adult Female Mice (Mus musculus) Balb/C Strain

Tapak dara plant is a plant that contains several active compounds, such as phenolic acids, flavonoids and alkaloids. The tapak dara plant can act as a sedative, urinary laxative, stop bleeding, and neutralize toxins. In addition, tapak dara leaf extract contains ingredients that can act as antifertilization. This study aimed to determine the effect of methanol extract of tapak dara leaf on the estrus cycle of adult female mice (Mus musculus) Balb/C strain. This research is an experimental research by testing cause and effect. The hypothesis test used in this study was one-way ANOVA and BNT test. The significance value of giving tapak dara leaf methanol extract to female mice showed a significant value so that it can be said that the administration of tapak dara leaf methanol extract caused the estrus cycle of female mice to be longer. The significance value of estrogenic activity in mice shows a significant value of 0.047, so it can be said that estrogen activity also affects the length of the estrus cycle. The results of hypothesis testing using the one-way ANOVA test were significant, so it can be concluded that the methanol extract of tapak dara leaves can cause the estrus cycle of female mice to be longer

PEMAHAMAN PENGUSAHA KENA PAJAK TERHADAP PENGGUNAAN E-FAKTUR (STUD KASUS PENGUSAHA KENA PAJAK KPP MADYA PALEMBANG)

Penelitian ini bertujuan untuk dapat mengetahui tingkat pemahaman Pengusaha Kena Pajak di KPP Madya Palembang. Metode analisis penelitian yang digunakan adalah kualitatif yang menggunakan penelitian deskriptif. Jenis data yang digunakan adalah data sekunder dan data primer dengan menyebarkan angket sebanyak 100 responden. Penelitian menggunakan teknik analisis data kualitatif dengan cara menganalisis hasil jawaban responden berupa persentasi. Hasil penelitian menunjukkan PKP telah memahami tentang e-Faktur, hal ini dilandasi oleh beberapa yaitu penggunaan e-Faktur dianggap sesuai kebutuhan sehingga mudah dipahami, aplikasi yang tidak terlalu jauh dengan proses pelaporan manual, publikasi dan sosialisasi direktorat Jendral Pajak yang telah maksima

Efektivitas Senam Osteoarthritis Terhadap Quality Of Life Pada Penderita Osteoarthritis

Osteoarthritis exercise is a conservative management component for osteoarthritis patients and universally recommended by clinical guidelines, joint involvement, pain intensity and functional. Quality of life is defined as an individual's perception of their life which includes the goals, standards, and welfare of life. To determine the effectiveness of osteoarthritis exercise as a guide to improve the of quality of life for patients with osteoarthritis. This research used quantitative methods with pre-experimental approach one group pre-test and post-test design with 40 respondents detected by osteoarthritis in Makam Haji village taken by purposive sampling technique. The measurement of quality of life used the WHO-BREF questionnaire, ethical clearance, and informed consent. The data were analyzed with SPSS 23 for windows program. Paired simple t-test different test results obtained (p = 0.180). This means that there is no significant difference between the value of quality of life before and after osteoarthritis exercise to osteoarthritis patients in Makam Haji Village (Ho accepted). However, there was an increased in each domain of quality of life before and after osteoarthritis exercise in the physical and psychological health domains. This study is the first study in Indonesia related to osteoarthritis in productive age respondents, although the results of the effectiveness of osteoarthritis exercise were not significantly different from before and after the intervention. However, there was an increased in quality of life after osteoarthritis exercises, namely in the physical and psychological health domain. Is expected to further researcher can improve the research to be more stringently in controlling the variables such as the frequency of the exercise, the quality and quantity of the exercise that will be deliver, and explore more deeply about the physical and psychological health domain of osteoarthritis patients, especially for productive age