529 research outputs found
Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages
Apicomplexan protozoan pathogens avoid destruction and establish a replicative niche within host cells by forming a nonfusogenic parasitophorous vacuole (PV). Here we present evidence for lysosome-mediated degradation of Toxoplasma gondii after invasion of macrophages activated in vivo. Pathogen elimination was dependent on the interferon Îł inducible-p47 GTPase, IGTP, required PI3K activity, and was preceded by PV membrane indentation, vesiculation, disruption, and, surprisingly, stripping of the parasite plasma membrane. Denuded parasites were enveloped in autophagosome-like vacuoles, which ultimately fused with lysosomes. These observations outline a series of mechanisms used by effector cells to redirect the fate of a classically nonfusogenic intracellular pathogen toward a path of immune elimination
Frustrated two-dimensional Josephson junction array near incommensurability
To study the properties of frustrated two-dimensional Josephson junction
arrays near incommensurability, we examine the current-voltage characteristics
of a square proximity-coupled Josephson junction array at a sequence of
frustrations f=3/8, 8/21, 0.382 , 2/5, and 5/12.
Detailed scaling analyses of the current-voltage characteristics reveal
approximately universal scaling behaviors for f=3/8, 8/21, 0.382, and 2/5. The
approximately universal scaling behaviors and high superconducting transition
temperatures indicate that both the nature of the superconducting transition
and the vortex configuration near the transition at the high-order rational
frustrations f=3/8, 8/21, and 0.382 are similar to those at the nearby simple
frustration f=2/5. This finding suggests that the behaviors of Josephson
junction arrays in the wide range of frustrations might be understood from
those of a few simple rational frustrations.Comment: RevTex4, 4 pages, 4 eps figures, to appear in Phys. Rev.
Experimental determination of the effective strong coupling constant
We present a first attempt to experimentally extract an effective strong
coupling constant that we define to be a low Q2 extension of a previous
definition by S. Brodsky et al. following an initial work of G. Grunberg. Using
Jefferson Lab data and sum rules, we establish its Q2-behavior over the
complete Q2-range. The result is compared to effective coupling constants
inferred from different processes and to calculations based on Schwinger-Dyson
equations, hadron spectroscopy or lattice QCD. Although the connection between
the experimentally extracted effective coupling constants and the calculations
is not established it is interesting to note that their behaviors are similar.Comment: Published in Physics Letters B 650 4 24
Melting behavior of ultrathin titanium nanowires
The thermal stability and melting behavior of ultrathin titanium nanowires
with multi-shell cylindrical structures are studied using molecular dynamic
simulation. The melting temperatures of titanium nanowires show remarkable
dependence on wire sizes and structures. For the nanowire thinner than 1.2 nm,
there is no clear characteristic of first-order phase transition during the
melting, implying a coexistence of solid and liquid phases due to finite size
effect. An interesting structural transformation from helical multi-shell
cylindrical to bulk-like rectangular is observed in the melting process of a
thicker hexagonal nanowire with 1.7 nm diameter.Comment: 4 pages, 4 figure
A Note on Inflation with Tachyon Rolling on the Gauss-Bonnet Brane
In this paper we study the tachyonic inflation in brane world cosmology with
Gauss-Bonnet term in the bulk. We obtain the exact solution of slow roll
equations in case of exponential potential. We attempt to implement the
proposal of Lidsey and Nunes, astro-ph/0303168, for the tachyon condensate
rolling on the Gauss-Bonnet brane and discuss the difficulties associated with
the proposal.Comment: RevTex4, 5 pages, no figures, Minor clarifications added and
references updated, To appear in PR
Complete measurement of three-body photodisintegration of 3He for photon energies between 0.35 and 1.55 GeV
The three-body photodisintegration of 3He has been measured with the CLAS
detector at Jefferson Lab, using tagged photons of energies between 0.35 GeV
and 1.55 GeV. The large acceptance of the spectrometer allowed us for the first
time to cover a wide momentum and angular range for the two outgoing protons.
Three kinematic regions dominated by either two- or three-body contributions
have been distinguished and analyzed. The measured cross sections have been
compared with results of a theoretical model, which, in certain kinematic
ranges, have been found to be in reasonable agreement with the data.Comment: 22 pages, 25 eps figures, 2 tables, submitted to PRC. Modifications:
removed 2 figures, improvements on others, a few minor modifications to the
tex
eta-prime photoproduction on the proton for photon energies from 1.527 to 2.227 GeV
Differential cross sections for the reaction gamma p -> eta-prime p have been
measured with the CLAS spectrometer and a tagged photon beam with energies from
1.527 to 2.227 GeV. The results reported here possess much greater accuracy
than previous measurements. Analyses of these data indicate for the first time
the coupling of the etaprime N channel to both the S_11(1535) and P_11(1710)
resonances, known to couple strongly to the eta N channel in photoproduction on
the proton, and the importance of j=3/2 resonances in the process.Comment: 6 pages, 3 figure
Measurement of the Deuteron Structure Function F2 in the Resonance Region and Evaluation of Its Moments
Inclusive electron scattering off the deuteron has been measured to extract
the deuteron structure function F2 with the CEBAF Large Acceptance Spectrometer
(CLAS) at the Thomas Jefferson National Accelerator Facility. The measurement
covers the entire resonance region from the quasi-elastic peak up to the
invariant mass of the final-state hadronic system W~2.7 GeV with four-momentum
transfers Q2 from 0.4 to 6 (GeV/c)^2. These data are complementary to previous
measurements of the proton structure function F2 and cover a similar
two-dimensional region of Q2 and Bjorken variable x. Determination of the
deuteron F2 over a large x interval including the quasi-elastic peak as a
function of Q2, together with the other world data, permit a direct evaluation
of the structure function moments for the first time. By fitting the Q2
evolution of these moments with an OPE-based twist expansion we have obtained a
separation of the leading twist and higher twist terms. The observed Q2
behaviour of the higher twist contribution suggests a partial cancellation of
different higher twists entering into the expansion with opposite signs. This
cancellation, found also in the proton moments, is a manifestation of the
"duality" phenomenon in the F2 structure function
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