Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy (vol 47, pg 73, 2015)

"Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy" published in Nature Genetics (2015), volume 47, pp.73-77

The genotoxicity of Tenofovir disoproxil fumarate in HBV-infected patients

Tenofovir disoproxil fumarate (TDF) is an acyclic nucleotide reverse transcriptase inhibitor used as antiviral therapeutic drug in hepatitis B virus (HBV) infection treatment. We investigated whether HBV itself or TDF could enhance genotoxicity in HBV infected patients. A total of 30 HBV-infected patients were included in this study: 10 were untreated, 10 took therapy for 6 months, 10 took therapy for 12 months and a further 15 were control group. We used the micronucleus test (MN) and mitotic index (MI) to assess the genotoxic effects of TDF. MN and MI frequency were significantly increased in all the HBV-infected patient groups when compared to control. However, significant differences were not found between different time points within the therapy groups. The current data indicate that chronic HBV infection without treatment has an effect on MN and MI. TDF administration at therapeutic doses for 12 months also did not reduce the MI and MN, suggesting its protective action against HBV induced genotoxic damage. Larger-scale and longtime studies are required for a better understanding of the genotoxicity of TDF. [Med-Science 2018; 7(3.000): 600-3

Preservice Teachers' Attitudes and Metaphor Perceptions towards Mathematics

WOS: 000449004100020In this study, preservice teachers' attitudes and metaphor perceptions towards mathematics were examined, the relationship between them was investigated and it was determined whether there was a significant difference according to the departments. In this context, in the 2015-2016 academic year, 358 preservice teachers in central Turkey were administered various scales such as "Mathematics attitude scale" ","Personal information form", and "Mathematics is like ..., because ..." and "If a mathematical movie genre (weather conditions) ..., it would be, because ... ". Content analysis was used in the analysis of the qualitative data. Spearman correlation test, Kruskal Wallis-H test and Mann Whitney-U test were used in the analysis of the quantitative data. As a result of the analysis, it has been recognized that the metaphors towards mathematics are divided into the conceptual categories as "Entertainment", "Basic need" "Emotion" and "Problem". There was a positive and strong significant relationship between the attitudes and metaphor perceptions towards mathematics of preservice teachers. Moreover, attitudes and metaphor perceptions towards mathematics were found to differ significantly according to the departments. Furthermore, this study has found that research with more than one metaphor is more effective

Reversal of left atrial-pulmonary vein remodeling in hypertensive heart disease

WOS: 000239117400021PubMed ID: 1690397

Light-emitting diode photobiomodulation: effect on bone formation in orthopedically expanded suture in rats-early bone changes

The aim of this experimental study was to evaluate histomorphometrically the effects of light-emitting diode (LED) photobiomodulation therapy (LPT) on bone formation in response to expansion of the interpremaxillary suture in rats. Twenty male, 50- to 60-day-old Wistar rats were divided into two equal groups (control and experimental). Both groups were subjected to expansion for 5 days, and 50 cN of force was applied to the maxillary incisors with helical spring. An OsseoPulseA (R) LED device, 618-nm wavelength and 20-mW/cm(2) output power irradiation, was applied to the interpremaxillary suture for 10 days. Bone formation in the sutural area was histomorphometrically evaluated, including the amount of new bone formation (in square micrometers), number of osteoblasts, number of osteoclasts, and number of vessels. Mann-Whitney U test was used for statistical evaluation at p < 0.025 level. Significant differences were found between groups for all investigated histomorphometric parameters. New bone formation area (p = 0.024, 1.48-fold), number of osteoblasts (p < 0.001, 1.59-fold), number of osteoclasts (p = 0.004, 1.43-fold), and number of vessels (p = 0.007, 1.67-fold) showed higher values in the experimental group than the control. Bone histomorphometric measurements revealed that bone architecture in the LPT group was improved. The application of LPT can stimulate bone formation in the orthopedically expanded interpremaxillary suture during expansion and the early phase of the retention periods

Copper(II) and palladium(II) complexes of 2-amino-5-chlorobenzophenone and 2-(2-hydroxybenzylidene)amino-5-chlorobenzophenone-S-methyl-thiosemicarbazones

The S-methyl thiosemicarbazone derivatives of 2-amino-5-chlorobenzophenone and 2-(2-hydroxybenzylidene) amino-5-chlorobenzophenone (L-I and L-II) and their copper(II) and palladium(II) chelates were synthesized. The solid compounds, [Cu( L-I) Cl]Cl center dot 2H(2)O, [Cu( L-II)Cl]Cl center dot H2O, [Pd(L-I) Cl]Cl, and [Pd(L-II)Cl-2], were characterized by elemental analysis, thermogravimetric measurements, electronic, i.r., H-1-n.m.r. and e.p.r. spectroscopy. The ligand behavior of the L-I and L-II explained by means of spectroscopic data. The experimental X-band e.p.r. spectra recorded from two different copper(II) ion coordinated powder complexes have characteristic line shapes that exhibit the axial symmetry around the paramagnetic ions. The theoretically well fitted spectra prove this case too. The absence of hyperfine signals has been attributed to the strong covalency effects of copper electrons with neighbouring N atoms. Orbital energy levels for magnetic electrons were determined from Spin Hamiltonian parameters. The anisotropic Lande splitting factors were specified in an order of g parallel to > g perpendicular to > 2 and this case indicates that the unpaired electrons are located mainly in the d(x2-y2)orbital

Ultrasound-Assisted Desorption Of Co2 From Carbon Dioxide Binding Organic Liquids

CO2 absorption/desorption performance of 2-tert-Butyl-1,1,3,3-tetramethylguanidine (BTMG) and 1-Hexanol blend, which is a novel carbon dioxide binding organic liquid (CO2BOL) system, was studied in order to investigate the behavior of ultrasoundassisted desorption. Pure CO2 was first absorbed into a 10 wt percent BTMG solution in a semi-batch stirred reactor at 303 K and at 2 atm until equilibrium was reached, followed by ultrasound-assisted desorption at 353 K under nitrogen atmosphere. Experiments were repeated in the absence of ultrasound, keeping everything else the same. The CO2 loading of BTMG: 1-Hexanol solvent system was found to be a very favourable ratio of 1.05 mol CO2/mol BTMG. When compared with conventional desorption, ultrasound-assisted desorption resulted in enhanced desorption rate so that the solvent regeneration time was significantly shortened. Enhancement of desorption rate was most significant/vigorous at the initial stages of desorption process. Further, regeneration of this CO2BOL was possible at 353 K without any phase change. Experimental results clearly show that the ultrasound-assisted desorption is an effective process intensification tool leading to significantly minimised energy consumption for regeneration. To ensure effectiveness of regeneration, reversibility of the solvent system was also investigated by using Fourier transform infrared spectrometry. (C) 2017 The Authors. Published by Elsevier Ltd.WoSScopu