Logical Operation Based Literature Association with Genes and its application, PosMed.

PosMed prioritizes candidate genes for positional cloning by employing our original database search engine GRASE, which uses an inferential process similar to an artificial neural network comprising documental neurons (or 'documentrons') that represent each document contained in databases such as MEDLINE and OMIM (Yoshida, _et al_. 2009, Makita, _et al_. 2009). PosMed immediately ranks the candidate genes by connecting phenotypic keywords to the genes through connections representing gene–gene interactions other biological relationships, such as metabolite–gene, mutant mouse–gene, drug–gene, disease–gene, and protein–protein interactions, ortholog data, and gene–literature connections.

To make proper relationships between genes and literature, we manually curate queries, which are defined by logical operation rules, against MEDLINE. For example, to detect a set of MEDLINE documents for the AT1G03880 gene in _A. thaliana_, we applied the following logical query: (‘AT1G03880’ OR ‘CRU2’ OR ‘CRB’ OR ‘CRUCIFERIN 2' OR ‘CRUCIFERIN B’) AND (‘Arabidopsis’) NOT (‘chloroplast RNA binding’). Curators refined these queries in mouse, rice and _A. thaliana_. For human and rat genes, we use mouse curation results via ortholog genes in PosMed.

PosMed is available at "http://omicspace.riken.jp/PosMed":http://omicspace.riken.jp/PosMed

References:
Yoshida Y, et al. _Nucleic Acids Res_. 37(Web Server issue):W147-52. 2009. 
Makita Y, et al. _Plant Cell Physiol_. 2009 Jul;50(7):1249-59.
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〈研究論文〉「科学の本質」教授における自然科学と他の知識領域との関係 : 国際バカロレアの「知の理論」を中心に

The purpose of this paper is to offer alternative ways in the instruction of the Nature of Science (NOS), while making connections with areas of knowledge outside the natural sciences. It focuses on the teaching of NOS in the Theory of Knowledge (TOK) course of the International Baccalaureate Organization, which is a curriculum that connects NOS with other areas of knowledges. To fulfil the purpose of this research, I analyzed two TOK course textbooks from two points of view. The first of these points refers to the question of what are the tenets of NOS that relate to other areas of knowledge. The second one explores the role of NOS in those cases in which natural sciences connect with other areas of knowledge. After pondering these two questions, I extracted an example from educational materials, and analyzed in detail the role of NOS..

死後のケアに伴う遺体からの感染予防対策に関する検討

本研究の目的は、医療施設における遺体からの感染予防対策を検討することである。死後のケアにおける遺体からの感染予防対策に関する文献および看護職を対象として、遺体からの感染予防対策に関する調査を行った。その結果、臨床での死後のケアにおける感染予防対策では、手袋の着用などユニバーサルプレコーションの考えに基づいて実践されていた。看護師によっては、死後のケアの実施後に遺体からの浸出液の漏出を懸念していた。また、家族が参加する際の手洗いの指導、葬送業従事者に対する遺体の感染に関する情報提供の必要性が示唆された。退院後に遺体から浸出液の漏出などのトラブルも報告されていることから、死後のケアを実践する者は、遺体に現れる特徴を理解して援助することが重要であると言える。The objective of this study was to investigate infection control from corpses in medical facilities. A literature review was conducted on the infection control from corpses in postmortem care, and a survey on the issue was conducted among nurses. The results showed that infection control corpses associated with postmortem care in clinical settings were implemented according to the concept of universal precautions, such as wearing gloves. Some nurses were concerned about leakage of fluid from corpses after postmortem care. The results suggested the need for instructing family members to wash their hands after handling deceased family members, and providing morticians with information on infections affecting particular corpses. Problems such as fluid leakage from corpses after discharge from hospital have been reported, and it is therefore important for postmortem care practitioners to understand the features of corpses and provide support

Removal of nitrogen by Antarctic yeast cells at low temperature

Nitrate removal in a medium (at 5°C ) and the effect of culture temperature on the fatty acid composition were investigated using Candida sp. which was isolated from the upper layer of Lake Vanda in the McMurdo Dry Valleys, Antarctica. The strain was cultured at 5°C aerobically, on a synthetic medium containing potassium nitrate (NO_3-N, 100 mgl^) as a nitrogen source, and examined the effects of pH and chlorine on growth and NO_3-N removal in the medium. Within the pH of 3 to 7 the yeast cells exhibited a similar removal of nitrate level. The strain grew well and also removed nitrate at chlorine concentrations of 5 and 10 mgl^ but did not grow at chlorine concentration of 20 mgl^. Decreasing the growth temperature induced an increase in the content of linolenic acid (18:3) in the yeast cells

マキエシ ハラ ヨウユウサイ ケンキュウ

卒業論

Trends in quality of life of in-unit hemodialysis patients

本研究の目的は,外来透析者の主観的な評価によりQOLを測定し,そのQOLの傾向を明らかにすることである。対象者は,名古屋･大阪･岡山･広島の4施設における外来透析者で,研究に同意を得られた341名とし,研究方法は,自己記入式質問紙法を用いた｡測定用具は,Ferrans & PowersのQuality of Life Index (QLI)を翻訳して用い,データ分析はプロマックス法による因子分析を行なった｡QLI項目を因子分析した結果,｢社会･経済的な機能｣｢家族･他者からの支え｣｢心の安寧｣｢身体の健康｣｢医療と教育｣の5因子が抽出された｡そして,｢家族･他者からの支え｣および｢医療と教育｣はQLI得点が高く,｢社会･経済的な機能｣および｢身体の健康｣は低いことが明らかになった｡従って,QOLを高めるためには,社会的側面や身体面をより重視して看護していくことが重要であると考えられた｡The purpose of this study is to clarify the quality of life (QOL) of in-unit hemodialysis patients. The subjects were 341 in-unit hemodialysis patients who agreed to participate in this study from four hospitals in Nagoya, Osaka, Okayama, and Hirosima. The Ferrans and Powers Quality of Life Index (QLI) Hemodialysis version (an authorised translation into Japanese) was used for measuring perceived quality of life. By factor analysis, 'socio-economic functioning', 'support from family and others', 'well-being of mind', 'physical health' and 'medical treatment and education' were extracted as five factors of the QOL. The QOL score on the 'support from family and others' was the highest of all, whereas 'physical health' and 'socio-economic functioning' were lower than other three factors. These results showed importance of physical and social dimensions in caring hemodialysis patients in clinical practice