Incidencia de la administración de recursos humanos en el desempeño laboral del Instituto Politécnico de Estelí –IPE, en el primer semestre 2016

En el presente estudio de investigación, se analizó la incidencia de la administración de recursos humanos en el desempeño laboral de los trabajadores del instituto politécnico Estelí en el primer semestre del año 2016, la cual describe el proceso que se utiliza para evaluar el personal. Posteriormente, se identificó el método de evaluación que se utilizan actualmente en la facultad con el fin de realizar una comparación entre la teoría y la práctica. Generalmente la función de recursos humanos está compuesta por áreas tales como el reclutamiento y selección, contratación capacitación, administración y gestión del personal durante la permanencia en la empresa. Al final del documento se encuentran las conclusiones y recomendaciones, las cuales permitirán a la facultad tomarlas en cuenta para mejora continua en la incidencia de la administración de recurso humano, donde la información fue encontrada en libros, páginas web, revistas, entre otras información de mucha importancia. Al final del documento se encuentran las conclusiones y recomendaciones, las cuales permitirán a la facultad tomarlas en cuenta para mejora continua en la incidencia de la administración de recurso humano, donde la información fue encontrada en libros, páginas web, revistas, entre otras información de mucha importancia

Geometry and Internal Structures of Flexural Folds (Ⅰ) Folding of a Single Competent Layer Enclosed in Thick Incompetent Layer

Some problems on folding of a single competent layer enclosed in thick incompetent layer, with regard to the variation in competency difference between the related rocks, have been examined on natural flexural folds, i. e., folds of quartz-rich layers in pelitic schist in the Kune district and the Oboke district, folds of quartz-rich layers in psammitic schist in the Oboke district, and folds of psammitic schist in pelitic schist in the Oboke district. Shape and orientation of the strain ellipsoid of mean strain of small domain in the Oboke and the Kune district, at the time when the buckle folding of competent layers and the cleaving (the formation of strain-slip cleavage) of incompetent matrix in that domain occurred, have been determined. The strain-slip cleavage in the incompetent matrix is correlated with the plane normal to the direction of maximum shortening, i. e., the principal plane XY of the mean strain ellipsoid. Geometric relationships between the strain ellipsoid of mean strain of a domain and geometric elements of buckle folds have been examined, especially where the enveloping surfaces of folded competent layers are inclined at angles of between 50° and 60° to the principal plane XY. At the initial stage of folding the axial surface shows a tendency to be normal to the layer being folded. For some folds the axial surfaces are completely rotated toward the principal plane XY when the interlimb angle becomes 90°-100°, but for some other folds they remain normal to the layer even when the interlimb angle becomes 700-80°. When the interlimb angle becomes smaller than 70-80°, the axial surfaces of all folds tend to rotate toward the principal plane XY. Although geometric relationship between the fold axes and the mean strain ellipsoid has not been strictly determined, the former does not appear to lie on the principal plane XY. The intensity of folding of competent layers, which is estimated by interlimb angle, is maximum for the layers parallel to the schistosity of the incompetent matrix and to the principal axis Z, and minimum for those normal to the schistosity and parallel to the axis Z, that showing the competency difference between different directions in the incompetent matrix, that is, the maximum competency in a direction parallel to the schistosity and the minimum in a direction normal to it. It has been clarified that for the folds of quartz-rich layers in pelitic schist of the Kune district and the Oboke district and those in psammitic schist of the Oboke district a linear relationship exists between the length of arc (L) and the thickness of the quartz-rich layer (T). In the former cases, the average L/T ratios are 14.9 (Kune) and 16.2 (Oboke), and the minimum L/T ratios are 9.1 and 11.6, while in the latter case the average L/T ratio is 11.6 and the minimum L/T ratio 5.8, respectively. Folds of psammitic layers in pelitic schist show frequently L/T ratios smaller than 1.00. On the assumption that during the folding pelitic schist, psammitic schist and quartz-rich layer behaved mechanically as Newtonian substance, the ratios of viscosity coefficient between those rocks have been esti-mated by using the average L/T ratios according to the wavelength equation of BIOT (1961). In the Oboke district, the viscosity ratio between the quartz-rich layer and the psammitic schist is ca. 38, that between the quartz-rich layer and the pelitic schist ca. 102, and that between the psammitic schist and the pelitic schist ca. 3 (indirectly estimated). In the Kune district, the viscosity ratio between the quart-rich layer and the pelitic schist is ca. 80. The relationship between the mechanisms of buckle folding and the internal structures, between the folding mechanisms and the viscosity ratios of the related rocks and between the folding mechanisms and the orientational relation of the buckled layer to the mean strain ellipsoid of the domain concerned have also been examined. Internal structure of buckle fold appears to be commonly characterized by the cleavage which is correlated with the principal plane XY of mean strain ellipsoid at any position of the fold. When buckled competent layer is a schistose rock, the cleavage is referred to the type of strain-slip cleavage, while for non-schistose rock it is referred to the type of flow cleavage. The strain pictures developed during the buckle folding of competent layers which arc parallel or subparallel to the principal axis Y (the intermediate axis = constant) have been classified into the following five types; Type I — the neutral axis is located at or near the middle part of fold knee, and the part of no-distortion is further developed at the inflection point and on the outermost side of the limbs. The principal axes X (the maximum extension axis) and Z(the maximum contraction axis) arc oriented normal to the fold axis. Type II — the neutral axis is developed at the outermost part of fold knee, and the part of no-distortion is rarely developed on the limbs. The principal axes X and Z are oriented normal to the fold axis, and the principal axis X is radially arranged through the fold. Type III — the neutral axis is not developed within the layer. The principal axes X and Z are oriented normal to the fold axis, though at the outermost part of fold knee X = Y. The principal axis X is radially arranged through the fold. Type IV— the neutral axis is not developed within the layer. At any position of the fold the mean strain ellipsoid is of the triaxial type. The principal axes X and Z arc oriented normal to the fold axis. The principal axis X is radially arranged through the fold. Type V —although the strain picture of this type may be essentially the same as that of Type IV, the angle β (angular deviation of the principal axis X beween both limbs) for the former is much smaller than that for the latter. The change of the strain picture from Type I to Type V corresponds to the decrease of the angle β. The strain pictures of Type I, Type II, Type III, Type IV and Type V are never the end member. The folds of quartz-rich layers in politic schist of the Kune district show the strain pictures of Type I, Type II and Type III, while those in psammitic schist show the strain pictures of Type II, Type III and Type IV. The folds of psammitic layers in pelitic schist show the strain picture of Type V. A definite relationship exists between the mechanisms of folding and the viscosity ratios of the related rocks, that is, the change of the strain picture from Type I to Type V corresponds to the decrease in the viscosity ratio, that showing a good agreement with RAMBERG'S theory (1964). Namely, the decrease of viscosity ratio of the related rocks corresponds to the increase of distance of between the neutral axis and the bottom surface of fold knee of the competent layer, and to the decrease of the angle β, when compared between the folds with the same inter-limb angle and the same initial thickness of layer. It has been pointed out that, if any fold is characterized the fan-like arrangement of cleavage with downward convergence, buckling instability played in general the by important role in the development of the fold. The nature of change of layer-thickness due to buckling has also been examined. For folds which show orthorhombic or near orthorhombic symmetry and larger interlimb angles, the competent layers show generally a tendency to be thickened at all positions of the folds and the amount of thickening appears to be maximum at the fold knee and minimum at the inflection point. The nature of change of layer-thickness due to buckling appears to be closely related to the type of strain picture (Type I to Type V) which is controlled by the viscosity ratio of the related rocks: with respect to the whole amount of layer shortening, the amount of layer thickening at the fold knee and the inflection point, and the difference in the amount of layer thickening between these two positions, Type I <Type II<Type III <Type IV <Type V, when compared between the folds with the same interlimb angle. Roughly speaking, the layer shortening due to the folding (interlimb angle = ca. 65°), which is characterized by the formation of the strain picture of Type I, may be less than ca. 10 per cent. That due to the folding for the strain picture of Type II may be between ca. 10 per cent and ca. 15 per cent. And, that due to the folding for the strain picture of Type IV—Type V may be larger than ca. 15 per Cent. For the fold of competent layer, therefore, the present length of arc is not always equal to the initial fold wavelength. From the measurement of the layer shortening for the folds of quartz-rich layers in the Kune district and the Oboke district, the average L/T ratios and the viscosity ratios between the related rocks have been re-estimated

Integrated monitoring and reviewing systems for the Rokkasho Spent Fuel Receipt and Storage Facility

The Rokkasho Spent Fuel Receipt and Storage (RSFS) Facility at the Rokkasho Reprocessing Plant (RRP) in Japan is expected to begin operations in 1998. Effective safeguarding by International Atomic Energy Agency (IAEA) and Japan Atomic Energy Bureau (JAEB) inspectors requires monitoring the time of transfer, direction of movement, and number of spent fuel assemblies transferred. At peak throughput, up to 1,000 spent fuel assemblies will be accepted by the facility in a 90-day period. In order for the safeguards inspector to efficiently review the resulting large amounts of inspection information, an unattended monitoring system was developed that integrates containment and surveillance (C/S) video with radiation monitors. This allows for an integrated review of the facility`s radiation data, C/S video, and operator declaration data. This paper presents an outline of the integrated unattended monitoring hardware and associated data reviewing software. The hardware consists of a multicamera optical surveillance (MOS) system radiation monitoring gamma-ray and neutron detector (GRAND) electronics, and an intelligent local operating network (ILON). The ILON was used for time synchronization and MOS video triggers. The new software consists of a suite of tools, each one specific to a single data type: radiation data, surveillance video, and operator declarations. Each tool can be used in a stand-alone mode as a separate ion application or configured to communicate and match time-synchronized data with any of the other tools. A data summary and comparison application (Integrated Review System [IRS]) coordinates the use of all of the data-specific review tools under a single-user interface. It therefore automates and simplifies the importation of data and the data-specific analyses

Effect Of Epa Ethyl Ester On Fatty Acid Profile In Hemodialysis Patients With Low Epa/Aa Ratio

BackgroundLarge amounts of n-3 polyunsaturated fatty acids are known to lower the risk of cardiovascular events (CVE). Serum eicosapentaenoic acid (EPA) / arachidonic acid (AA) ratio may potentially be a predictor of CVE which is the most common cause of death in hemodialysis (HD) patients. Therefore, we estimated the effect of EPA ethyl ester on fatty acid profile in HD patients.Subjects & MethodsFatty acid profile and high sensitivity CRP (hs-CRP) were measured in 131 patients receiving maintenance HD. Among these, 64 patients (F:M=25:39) with both low EPA/AA ratio (≦0.4) and negative CRP were enrolled in this randomized study (Group A, EPA administrated group, n=30; Group B, EPA non-administrated group, n=34). The mean age of the patients was 66.5 ± 11.9 years old and the duration of HD was 8.4 ± 7.9 years. The serum levels of EPA, AA, docosahexaenoic acid (DHA), and dihomogammalinolenic acid (DHL-A) were measured by gas chromatography (SRL, Tokyo, Japan).ResultsThe mean levels of EPA/AA ratio, DHA/AA ratio, DHL-A, non HDL-C and GNRI (Geriatric Nutritional Risk Index) were 0.28±0.13, 0.62±0.15, 22.7±8.4 μg/ml, 112.2±31.0 mg/dl and 93.6±5.5, respectively. After one month of treatment with EPA in group A, EPA/AA ratio was significantly increased (0.30±0.15 vs. 0.95±0.45, p<0.0001) and DHL-A significantly decreased (22.7±7.4 vs. 15.7±6.8, p= 0.0003), but DHA/AA ratio, serum non HDL-C and phosphate levels did not change. EPA/AA ratio was significantly higher and DHL-A lower in group A compared with group B after one month of the start of study.ConclusionsMedication of EPA for one month increases EPA/AA ratio, and decreases DHL-A level without the change of serum phosphate level in HD patients with low EPA/AA ratio

Neuromelanin‐Sensitive Magnetic Resonance Imaging Using DANTE Pulse

BACKGROUND: Neuromelanin-sensitive magnetic resonance imaging techniques have been developed but currently require relatively long scan times. The aim of this study was to assess the ability of black-blood delay alternating with nutation for tailored excitation-prepared T1-weighted variable flip angle turbo spin echo (DANTE T1-SPACE), which provides relatively high resolution with a short scan time, to visualize neuromelanin in the substantia nigra pars compacta (SNpc). METHODS: Participants comprised 49 healthy controls and 25 patients with Parkinson's disease (PD). Contrast ratios of SNpc and hyperintense SNpc areas, which show pixels brighter than thresholds, were assessed between DANTE T1-SPACE and T1-SPACE in healthy controls. To evaluate the diagnostic ability of DANTE T1-SPACE, the contrast ratios and hyperintense areas were compared between healthy and PD groups, and receiver operating characteristic analyses were performed. We also compared areas under the curve (AUCs) between DANTE T1-SPACE and the previously reported gradient echo neuromelanin (GRE-NM) imaging. Each analysis was performed using original images in native space and images transformed into Montreal Neurological Institute space. Values of P < 0.05 were considered significant. RESULTS: DANTE T1-SPACE showed significantly higher contrast ratios and larger hyperintense areas than T1-SPACE. On DANTE T1-SPACE, healthy controls showed significantly higher contrast ratios and larger hyperintense areas than patients with PD. Hyperintense areas in native space analysis achieved the best AUC (0.94). DANTE T1-SPACE showed AUCs as high as those of GRE-NM. CONCLUSIONS: DANTE T1-SPACE successfully visualized neuromelanin of the SNpc and showed potential for evaluating PD. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society

Two-Minute Quantitative Susceptibility Mapping From Three-Dimensional Echo-Planar Imaging: Accuracy, Reliability, and Detection Performance in Patients With Cerebral Microbleeds

Objectives: The aim of this study was to assess the accuracy, reliability, and cerebral microbleed (CMB) detection performance of 2-minute quantitative susceptibility mapping (QSM) from 3-dimensional echo-planar imaging (3D-EPI). Materials and Methods: Gadolinium phantom study was conducted using 3D-EPI, single–echo time (TE), and multi-TE gradient-recalled echo (GRE) sequences on two 3-T magnetic resonance (MR) scanners to assess the accuracy between measured and theoretical susceptibility values. The institutional review board approved this prospective study, and 40 healthy volunteers were enrolled with written consent between April 2018 and October 2019. Each underwent 3D-EPI, single-TE, and multi-TE GRE sequences consecutively on one 3-T MR scanner, and QSMs were calculated to assess the reliability of 3D-EPI QSM. Intraclass correlation coefficient (ICC), linear regression, and Bland-Altman plots were calculated. Patients with CMB who underwent both 3D-EPI and GRE QSM scans were retrospectively enrolled. Two radiologists evaluated images independently, and Cohen κ coefficients were calculated to compare CMB detection performance. Results: Phantom study showed excellent validity of 3D-EPI QSM on both MR scanners: Skyra, R2 = 0.996, P < 0.001, ICC = 0.997, mean difference, −2 ppb (95% confidence interval [CI], −45 to 40 ppb); Prisma, R2 = 0.992, P < 0.001, ICC = 0.988, mean difference, 15 ppb (95% CI, −67 to 97 ppb). A human study of 40 healthy volunteers (59 ± 13 years, 25 women) showed excellent reliability with 3D-EPI QSM for both single-TE and multi-TE GRE (R2 = 0.981, P < 0.001, ICC = 0.988; R2 = 0.983, P < 0.001, ICC = 0.990, respectively), supported by a Bland-Altman mean difference of 4 ppb (95% CI, −15 to 23 ppb) for single-TE GRE and 3 ppb (95% CI, −15 to 20 ppb) for multi-TE GRE. The CMB detection performance evaluation from 38 patients (51 ± 20 years, 20 women) showed almost perfect agreement between 3D-EPI and GRE QSM for both raters (κ = 0.923 and 0.942, P < 0.001). Conclusions: Faster QSM from 3D-EPI demonstrated excellent accuracy, reliability, and CMB detection performance

Biological characteristics of Mrakia sp. SK-4 strain from Antarctica

第2回極域科学シンポジウム/第33回極域生物シンポジウム 11月18日（金） 統計数理研究所 3階リフレッシュフロ

Relationship between Plasma Concentrations of Afatinib and the Onset of Diarrhea in Patients with Non-Small Cell Lung Cancer

We evaluated the area under the plasma concentration–time curve (AUC) of afatinib required to avoid the onset of grade 2 or higher diarrhea. The C0 and AUC0–24 of afatinib were significant higher in patients with grade 2 diarrhea than in those with grade 0–1 diarrhea. The areas under the receiver operator curves were 0.795 with the highest sensitivity (89%) and specificity (74%) at an AUC0–24 threshold of 823.5 ng h/mL, and 0.754 with the highest sensitivity (89%) and specificity (74%) at a C0 threshold of 28.5 ng/mL. In Kaplan–Meier analysis based on these cut-off AUC0–24 and C0 values, the median time to the incidence of grade 2 diarrhea was 16 days. The predicted AUC0–24 of afatinib from the single point of C6 showed the highest correlation with the measured AUC0–24 (r2 = 0.840); however, a significant correlation between the AUC0–24 and C0 was also observed (r2 = 0.761). C0 could be used as a marker of therapeutic drug monitoring because afatinib C0 was related to AUC0–24. Therefore, afatinib C0 should be monitored on day 8 after beginning therapy, and the daily dose of afatinib should be adjusted as an index with a cut-off value of 28.5 ng/mL

Quiet Diffusion-weighted MR Imaging of the Brain for Pediatric Patients with Moyamoya Disease

PURPOSE: Diffusion-weighted MRI (DWI) is an essential sequence for evaluating pediatric patients with moyamoya disease (MMD); however, acoustic noise associated with DWI may lead to motion artifact. Compared with conventional DWI (cDWI), quiet DWI (qDWI) is considered less noisy and able to keep children more relaxed and stable. This study aimed to evaluate the suitability of qDWI compared with cDWI for pediatric patients with MMD. METHODS: In this observational study, MR examinations of the brain were performed either with or without sedation in pediatric patients with MMD between September 2017 and August 2018. Three neuroradiologists independently evaluated the images for artifacts and restricted diffusion in the brain. The differences between qDWI and cDWI were compared statistically using a chi-square test. RESULTS: One-hundred and six MR scans of 56 patients with MMD (38 scans of 15 sedated patients: 6 boys and 9 girls; mean age, 5.2 years; range, 1-9 years; and 68 scans of 42 unsedated patients: 19 boys and 23 girls; mean age, 10.7 years; range, 7-16 years) were evaluated. MR examinations were performed either with or without sedation (except in one patient). In sedated patients, no artifact other than susceptibility was observed on qDWI, whereas four artifacts were observed on cDWI (P = .04). One patient awoke from sedation during cDWI scanning, while no patient awoke from sedation during qDWI acquisition. For unsedated patients, three scans showed artifacts on qDWI, whereas two scans showed artifacts on cDWI (P = .65). Regarding restricted diffusion, qDWI revealed three cases, while two cases were found on cDWI (P = .66). CONCLUSION: qDWI induced fewer artifacts compared with cDWI in sedated patients, and similar frequencies of artifacts were induced by qDWI and by cDWI in unsedated patients. qDWI showed restricted diffusion comparable to cDWI