Ancient China and its Eurasian Neighbors: Artifacts, Identity, and Death in the Frontier, 3000-700 BCE

This volume examines the role of objects in the region north of early dynastic state centers, at the intersection of Ancient China and Eurasia, a large area that stretches from Xinjiang to the China Sea, from c.3000 BCE to the mid-eighth century BCE. This area was a frontier, an ambiguous space that lay at the margins of direct political control by the metropolitan states, where local and colonial ideas and practices were reconstructed transculturally. These identities were often merged and displayed in material culture. Types of objects, styles, and iconography were often hybrids or new to the region, as were the tomb assemblages in which they were deposited and found. Patrons commissioned objects that marked a symbolic vision of place and person and that could mobilize support, legitimize rule, and bind people together. Through close examination of key artifacts, this book untangles the considerable changes in political structure and cultural makeup of ancient Chinese states and their northern neighbors.https://cupola.gettysburg.edu/books/1138/thumbnail.jp

Immunodeficiency in Pancreatic Adenocarcinoma with Diabetes Revealed by Comparative Genomics

Purpose: Pancreatic adenocarcinomas (PAAD) often are not diagnosed until their late stages, leaving no effective treatments. Currently, immunotherapy provides a promising treatment option against this malignancy. However, a set of immunotherapy agents benefit patients with many types of cancer, but not PAAD. Sharing the origin in the same organ, diabetes and PAAD tend to occur concurrently. We aimed to identify the impact of diabetes on immunotherapy of PAAD by conducting a comparative genomics analysis.Experimental Design: We analyzed level 3 PAAD genomics data (RNAseq, miRNAseq, DNA methylation, somatic copy number, and somatic mutation) from The Cancer Genome Atlas (TCGA) and Firehose. The differential molecular profiles in PAAD with/out diabetes were performed by the differential gene expression, pathway analysis, epigenetic regulation, somatic copy-number alteration, and somatic gene mutation.Results: Differential gene expression analysis revealed a strong enrichment of immunogenic signature genes in diabetic individuals, including PD-1 and CTLA4, that were currently targetable for immunotherapy. Pathway analysis further implied that diabetic individuals were defective in immune modulation genes. Somatic copy-number aberration (SCNA) analysis showed a higher frequency of amplification and deletion occurred in the cohort without diabetes. Integrative analysis revealed strong association between differential gene expression, and epigenetic regulations, however, seemed not affected by SCNAs. Importantly, our somatic mutation analysis showed that the occurrence of diabetes in PAAD was associated with a large set of gene mutations encoding genes participating in immune modulation.Conclusions: Our analysis reveals the impact of diabetes on immunodeficiency in PAAD patients and provides novel insights into new therapeutic opportunities

Sarrus-inspired deployable polyhedral mechanisms

Deployable polyhedral mechanisms (DPMs) have witnessed flourishing growth in recent years because of their potential applications in robotics, space exploration, structure engineering, and so forth. This paper firstly presents the construction, mobility and kinematics of a family of Sarrus-inspired deployable polyhedral mechanisms. By carrying out expansion operation and implanting Sarrus linkages along the straight-line motion paths, deployable tetrahedral, cubic and dodecahedral mechanisms are identified and constructed following tetrahedral, octahedral, and icosahedral symmetry, respectively. Three paired transformations with synchronized radial motion between Platonic and Archimedean polyhedrons are revealed, and their significant symmetric properties are perfectly remained in each work configuration. Subsequently, with assistant of equivalent prismatic joints, the equivalent analysis strategy for mobility of multiloop polyhedral mechanisms is proposed to significantly simplify the calculation process. This paper hence presents the construction method and equivalent analysis of the Sarrus-inspired DPMs that are not only valuable in theoretical investigation, but also have great potential in practical applications such as mechanical metamaterials, deployable architectures and space exploration

Hamiltonian-path based constraint reduction for deployable polyhedral mechanisms

Most of the deployable polyhedral mechanisms (DPMs) are multi-loop overconstrained mechanisms that causes barriers for their applications due to the issues in assembly, operation and control. Yet, constraint reduction for these multi-loop overconstrained mechanisms is extremely challenging in kinematics. In this paper, by introducing the Hamiltonian path to investigate the 3D topological graphs of a group of Sarrus-inspired DPMs, we propose a systematic method for constraint reduction of multi-loop overconstrained DPMs. We demonstrate that through the removal of redundant joints with the assistant of tetrahedral Hamiltonian path, one equivalent simplest topological graph of tetrahedral mechanism is identified as a reduction basic unit. Subsequently, one simplest form of Sarrus-inspired cubic mechanism is obtained by investigating two Hamiltonian paths of its dual octahedron and sequentially arranging basic units. Furthermore, a total of nineteen simplest forms of Sarrus-inspired dodecahedral mechanisms are identified from seventeen Hamiltonian paths of its dual icosahedron. The overconstraints in each simplest Sarrus-inspired DPM are greatly reduced while preserving the original one-degree-of-freedom (DOF) motion behavior. The method proposed in this paper not only lays the groundwork for further research in wider deployable polyhedrons, but also inspires the reduction of other multi-loop overconstrained mechanisms, with potential applications in the fields of manufacturing, architecture and space exploration

Increase in acid sphingomyelinase level in human retinal endothelial cells and CD34+ circulating angiogenic cells isolated from diabetic individuals is associated with dysfunctional retinal vasculature and vascular repair process in diabetes

BACKGROUND: Diabetic retinopathy is a microvascular disease that results from retinal vascular degeneration and defective repair due to diabetes-induced endothelial progenitor dysfunction. OBJECTIVE: Understanding key molecular factors involved in vascular degeneration and repair is paramount for developing effective diabetic retinopathy treatment strategies. We propose that diabetes-induced activation of acid sphingomyelinase (ASM) plays essential role in retinal endothelial and CD34+ circulating angiogenic cell (CAC) dysfunction in diabetes. METHODS: Human retinal endothelial cells (HRECs) isolated from control and diabetic donor tissue and human CD34+ CACs from control and diabetic patients were used in this study. ASM messenger RNA and protein expression were assessed by quantitative polymerase chain reaction and enzyme-linked immunosorbent assay, respectively. To evaluate the effect of diabetes-induced ASM on HRECs and CD34+ CACs function, tube formation, CAC incorporation into endothelial tubes, and diurnal release of CD34+ CACs in diabetic individuals were determined. RESULTS: ASM expression level was significantly increased in HRECs isolated from diabetic compared with control donor tissue, as well as CD34+ CACs and plasma of diabetic patients. A significant decrease in tube area was observed in HRECs from diabetic donors compared with control HRECs. The tube formation deficiency was associated with increased expression of ASM in diabetic HRECs. Moreover, diabetic CD34+ CACs with high ASM showed defective incorporation into endothelial tubes. Diurnal release of CD34+ CACs was disrupted with the rhythmicity lost in diabetic patients. CONCLUSION: Collectively, these findings support that diabetes-induced ASM upregulation has a marked detrimental effect on both retinal endothelial cells and CACs