Deconfinement Phase Transition Heating and Thermal Evolution of Neutron Stars

The deconfinement phase transition will lead to the release of latent heat during spins down of neutron stars if the transition is the first-order one.We have investigated the thermal evolution of neutron stars undergoing such deconfinement phase transition. The results show that neutron stars may be heated to higher temperature.This feature could be particularly interesting for high temperature of low-magnetic field millisecond pulsar at late stage.Comment: 4 pages, to be published by American Institute of Physics, ed. D.Lai, X.D.Li and Y.F.Yuan, as the Proceedings of the conference Astrophysics of Compact Object

Multidrug-resistant Escherichia coli and Tetracycline-resistant Enterococcus faecalis in wild raptors of Alabama and Georgia, USA

Wild birds inhabit in a wide variety of environments and can travel great distances. Thus, wild birds can possibly spread antimicrobial resistance along the way, and this may represent a potential public health concern. We characterized antimicrobial resistance in fecal Escherichia coli and Enterococcus faecalis in wild raptors in the southeastern US. Cloacal samples were collected from 118 wild raptors of 17 species from 18 counties in Alabama and 15 counties in Georgia. A total of 112 E. coli and 76 E. faecalis isolates were recovered, and we found significantly more antimicrobial-resistant E. coli (20/112, 18%) than E. faecalis (6/76, 8%; P = 0.05). Five antimicrobial-resistant genes: blaTEM-1, blaCTX-M-1, tet(M), cmlA, cat, and gyrA, were identified in antimicrobial-resistant E. coli isolates. Five of 13 (38%) ampicillin-resistant E. coli harbored both bla-TEM-1 and blaCTX-M-1 genes, indicating they are extended-spectrum beta-lactamase-carrying strains. Both of the tetracycline resistance genes, tet(M) and tet(L), were identified in E. faecalis isolates. Wild raptors seem to be a reservoir host of antimicrobial-resistant E. coli and E. faecalis and may represent a hazard to animal and human health by transmission of these isolates

Tryptophan-kynurenine pathway as a novel link between gut microbiota and schizophrenia: A review

Gut microbiota and its metabolite tryptophan play an important role in regulating neurotransmission, immune homeostasis and oxidative stress which are critical for brain development. The kynurenine pathway is the main route of tryptophan catabolism. Kynurenine metabolites regulate many biological processes including host-microbiome communication, immunity and oxidative stress, as well as neuronal excitability. The accumulation of metabolites produced by kynurenine pathway in brain results in the activation of the immune system (increase in the levels of inflammatory factors) and oxidative stress (production of reactive oxygen species, ROS), which are associated with mental disorders, for example schizophrenia. Thus, it was hypothesized that perturbations in kynurenine pathway could cause activation of immunity, and that oxidative stress may be involved in the etiology of schizophrenia. The present work is a review of the latest studies on the possible role of kynurenine pathway in schizophrenia, and mechanism(s) involved

Meta-Analysis of Chinese Patent Medicine Combined with Zoledronic Acid in the Treatment of Primary Osteoporosis

Objective: To systematically evaluate the safety and efficacy of Chinese patent medicine combined with zoledronic acid in the treatment of primary osteoporosis. Methods: CnKI, VIP, Wanfang Database, Chinese Biomedical literature database, PubMed, Web of Science, The Cochrane Library, Embase and CnKI were searched by computer RCTs of clinical randomized controlled trials of Chinese patent medicine combined with zoledronic acid in the treatment of primary osteoporosis in Embase database were retrieved from the database construction to April 1, 2022, and meta-analysis was performed using RevMan 5. 3 software. Results: A total of 14 RCTs were included, and the results of meta-analysis showed that:Compared with the control group, Chinese patent medicine combined with zoledronic acid had significant effects on the improvement of total clinical response rate, VAS score, MDL score, lumbar vertebra bone mineral density, femoral neck bone mineral density, Ward's triangle bone mineral density, osteocalcin and ALP, and significantly reduced alkaline phosphatase, with statistically significant differences. It had no significant effect on serum phosphorus, calcium and adverse reactions (P >0. 05). Conclusion: The safety and efficacy of Chinese patent medicine combined with zoledronic acid in the treatment of POP are clear, but the quality of the included studies is limited, and more high-quality studies are needed to enhance the evaluation evidence