转铁蛋白-转铁蛋白受体系统在药物运输和定向给药中的应用

2003-2004 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Study on the purification of soy isoflavone by supercritical CO2 antisolvent process

2002-2003 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Simple modeling for conducted common-mode current in switching circuits

Common mode current strongly depends on stray capacitance of each circuit node, especially those with high dv/dt and di/dt. To build a simple model for conducted common mode current in switching circuit a computer software based on Partial Element Equivalent Circuit (PEEC) method is used to calculate the parasitic elements of the printed circuit board (PCB). Simulation results agree well with experimental results up to 10 MHz.published_or_final_versio

The study on static bifurcation behavior of the immobilized yeast spherical beads for ethanol production

2003-2004 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

The chaotic behavior of saccharomyces cerevisiae culture system in CSTR

2002-2003 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

The new advances in sulforaphen

2002-2003 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

The effect of immobilization process to the activity of mthase and mtsase

2003-2004 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Hepcidin and iron homeostasis

2003-2004 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Trehalose production by permeabilized cells

2004-2005 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

c-Abl downregulates the slow phase of double-strand break repair

c-Abl tyrosine kinase is activated by agents that induce double-strand DNA breaks (DSBs) and interacts with key components of the DNA damage response and of the DSB repair machinery. However, the functional significance of c-Abl in these processes, remained unclear. In this study, we demonstrate, using comet assay and pulsed-field gel electrophoresis, that c-Abl inhibited the repair of DSBs induced by ionizing radiation, particularly during the second and slow phase of DSB repair. Pharmacological inhibition of c-Abl and c-Abl depletion by siRNA-mediated knockdown resulted in higher DSB rejoining. c-Abl null MEFs exhibited higher DSB rejoining compared with cells reconstituted for c-Abl expression. Abrogation of c-Abl kinase activation resulted in higher H2AX phosphorylation levels and higher numbers of post-irradiation γH2AX foci, consistent with a role of c-Abl in DSB repair regulation. In conjunction with these findings, transient abrogation of c-Abl activity resulted in increased cellular radioresistance. Our findings suggest a novel function for c-Abl in inhibition of the slow phase of DSB repair