SOFT POWER OF INTERNATIONAL NEWS MEDIA: AMERICAN AUDIENCES’ PERCEPTIONS OF CHINA’S COUNTRY IMAGE MEDIATED BY TRUST IN NEWS

This experimental study explores the concept of “soft power” in the context of international news management and concepts that may influence soft power, such as trust in news. Specifically, this study investigated how a news source (Chinese versus American) and the valence of a news story (positive versus negative news) affect an audience’s perception of a country’s image along with several dimensions. Theories on social categorization from psychology and image management theory from public relations were synthesized with branding and international politics in a cross-cultural communication context. Hypotheses predicted that positive images or “soft power” for a foreign country would be mediated by the audience’s perceived trust in news coverage. Results suggested that regardless of the source or valence of a news story, the aspects of China’s image in the contexts of responsibility and leadership - were enhanced significantly by mere exposure to news about China. However, positive news about China did not always work in favor of the country’s image. When comparing effects of source, negative news about China from a Chinese source enhanced Americans’ perceived image of China as a socially responsible country while the identical news story presented with a U.S. news source had little effect. American participants also perceived negative news stories to be more objective (regardless of its source). Finally, American participants perceived the American news source as more accurate and objective as compared to when the identical news story was presented with a Chinese media source

Political Engagement During a Presidential Election Year: A Case Study of Media Literacy Students

This exploratory, mixed-methods study uses data gathered during the previous U.S. presidential election in 2012 to evaluate student political engagement and digital culture. Survey results and media diary entries revealed that college students enrolled in a media literacy course during Super Tuesday or Election Day gravitated toward low-barrier political actions and expressive modes of citizenship, and they were most engaged when there was a social component to following election news. These results, coupled with recent data on political engagement and media consumption, present an opportunity to consider the role of digital platforms and online communities in the 2016 election

Gut microbiota-derived metabolite Trimethylamine-N-oxide (TMAO) and multiple health outcomes:an umbrella review and updated meta-analysis

BACKGROUND: Trimethylamine-N-oxide (TMAO) is a gut microbiota-derived metabolite produced from dietary nutrients. Many studies have discovered that circulating TMAO levels are linked to a wide range of health outcomes. OBJECTIVES: This study aimed to summarize health outcomes related to circulating TMAO levels. METHODS: We searched Embase, Medline, Web of Science and Scopus databases from inception to 15 February 2022 to identify and update meta-analyses examining the associations between TMAO and multiple health outcomes. For each health outcome, we estimated the summary effect size, 95% prediction confidence interval (CI), between-study heterogeneity, evidence of small-study effects, and evidence of excess-significance bias. These metrics were used to evaluate the evidence credibility of the identified associations. RESULTS: This umbrella review identified 24 meta-analyses that investigated the association between circulating TMAO levels and health outcomes including all-cause mortality, cardiovascular diseases, diabetes mellitus, cancer, and renal function. We updated these meta-analyses by including a total of 82 individual studies in 18 unique health outcomes. Among them, 14 associations were nominally significant. After evidence credibility assessment, we found six (33%) associations (i.e., all-cause mortality, cardiovascular disease mortality, major adverse cardiovascular events, hypertension, diabetes mellitus, and glomerular filtration rate) to present highly suggestive evidence. CONCLUSIONS: TMAO might be a novel biomarker related to human health conditions including all-cause mortality, hypertension, cardiovascular disease, diabetes, cancer and kidney function. Further studies are needed to investigate whether circulating TMAO levels could be an intervention target for chronic disease

Computational cardiac modeling reveals mechanisms of ventricular arrhythmogenesis in long QT syndrome type 8:CACNA1C R858H mutation linked to ventricular fibrillation

Functional analysis of the L-type calcium channel has shown that the CACNA1C R858H mutation associated with severe QT interval prolongation may lead to ventricular fibrillation (VF). This study investigated multiple potential mechanisms by which the CACNA1C R858H mutation facilitates and perpetuates VF. The Ten Tusscher-Panfilov (TP06) human ventricular cell models incorporating the experimental data on the kinetic properties of L-type calcium channels were integrated into one-dimensional (1D) fiber, 2D sheet, and 3D ventricular models to investigate the pro-arrhythmic effects of CACNA1C mutations by quantifying changes in intracellular calcium handling, action potential profiles, action potential duration restitution (APDR) curves, dispersion of repolarization (DOR), QT interval and spiral wave dynamics. R858H “mutant” L-type calcium current (ICaL) augmented sarcoplasmic reticulum calcium content, leading to the development of afterdepolarizations at the single cell level and focal activities at the tissue level. It also produced inhomogeneous APD prolongation, causing QT prolongation and repolarization dispersion amplification, rendering R858H “mutant” tissue more vulnerable to the induction of reentry compared with other conditions. In conclusion, altered ICaL due to the CACNA1C R858H mutation increases arrhythmia risk due to afterdepolarizations and increased tissue vulnerability to unidirectional conduction block. However, the observed reentry is not due to afterdepolarizations (not present in our model), but rather to a novel blocking mechanism

Characteristics of the participants according to geriatric nutritional risk index categories.

<p>Characteristics of the participants according to geriatric nutritional risk index categories.</p

The Geriatric Nutritional Risk Index Predicts Survival in Elderly Esophageal Squamous Cell Carcinoma Patients with Radiotherapy

<div><p>The impact of nutritional status on survival among elderly esophageal squamous cell carcinoma (ESCC) patients undergoing radiotherapy is unclear. In this study, we aimed at validating the performance of the geriatric nutritional risk index (GNRI) in predicting overall survival time in elderly ESCC patients with radiotherapy. A retrospective cohort study was conducted on 239 ESCC patients aged 60 and over admitted consecutively from January 2008 to November 2014 in the Department of Radiotherapy, Henan Tumor Hospital (Affiliated Tumor Hospital of Zhengzhou University), Zhengzhou, Henan, China. All patients were subjected to nutritional screening using GNRI, and were followed for the occurrence of lymphatic node metastasis, radiation complication and mortality. The Kaplan–Meier method with Log-rank test was used to estimate survival curves. Univariable Cox regression analysis was used to identify variables associated with overall survival time. Among the 239 patients, 184 patients (76.9%) took no nutritional risk, 32 patients (13.4%) took moderate risk of malnutrition, and 23 patients (9.7%) took a high risk of malnutrition. Univariable Cox regression showed that both high nutritional risk group and moderate nutritional risk group were significantly less likely to survive than no nutritional risk patients (hazard ratio (HR) = 1.688, 95% confidence interval (CI) = 1.019–2.798 for moderate risk group, and HR = 2.699, 95% CI = 1.512–4.819 for high risk group, respectively). The GNRI is an independent prognostic factor for overall survival time in elderly ESCC patients with radiotherapy. A GNRI ≤98 can be suggested as an indicator of surviving less.</p></div

Kaplan–Meier survival curves showing patient overall survival stratified by GNRI categories (high risk, <92; moderate risk, 92 to 98; no risk, >98.

<p>Kaplan–Meier survival curves showing patient overall survival stratified by GNRI categories (high risk, <92; moderate risk, 92 to 98; no risk, >98.</p

Univariate analysis of factors associated with overall survival.

<p>Univariate analysis of factors associated with overall survival.</p