GEOCHEMISTRY, ZIRCON U-PB GEOCHRONOLOGY, ND-HF ISOTOPIC CHARACTERISTICS AND TECTONIC IMPLICATIONS OF THE SOUTH MUYA BLOCK METASEDIMENTS (NORTHEASTERN CENTRAL ASIAN OROGENIC BELT)

The Neoproterozoic to Cenozoic collage of the Central Asian Orogenic Belt is well-known to include Precambrian continental blocks and microcontinents traditionally attributed to rifting of Siberia or Gondwana prior to CAOB assembly that significantly contributed into the geochemical and isotopic composition of younger subduction- and accretion-related crustal lithologies via processes of crust-mantle interaction and crustal recycling.The Neoproterozoic to Cenozoic collage of the Central Asian Orogenic Belt is well-known to include Precambrian continental blocks and microcontinents traditionally attributed to rifting of Siberia or Gondwana prior to CAOB assembly that significantly contributed into the geochemical and isotopic composition of younger subduction- and accretion-related crustal lithologies via processes of crust-mantle interaction and crustal recycling

GEOCHRONOLOGY AND SR-ND ISOTOPE GEOCHEMISTRY OF LATE PALEOZOIC COLLISIONAL GRANITOIDS OF UNDINSKY COMPLEX (EASTERN TRANSBAIKAL REGION)

There are several geodynamic models of the Central Asian Orogenic Belt (CAOB) development [Şengör et al., 1993, Zorin, 1999; Parfenov et al., 1999, 2003; Willem et al., 2012; and others]. The Mongol-Okhotsk Orogenic Belt (MOB) represents important part of CAOB. All geodymanic models of Late Riphean to Paleozoic structures of CAOB emphasize significance of subduction processes along Northern Asian craton margin at that time. Collage of CAOB terrains formed as a result of accretion of island arc, accretionary wedge, turbidite, and continental margin terrains to the Siberian paleocontinent.There are several geodynamic models of the Central Asian Orogenic Belt (CAOB) development [Şengör et al., 1993, Zorin, 1999; Parfenov et al., 1999, 2003; Willem et al., 2012; and others]. The Mongol-Okhotsk Orogenic Belt (MOB) represents important part of CAOB. All geodymanic models of Late Riphean to Paleozoic structures of CAOB emphasize significance of subduction processes along Northern Asian craton margin at that time. Collage of CAOB terrains formed as a result of accretion of island arc, accretionary wedge, turbidite, and continental margin terrains to the Siberian paleocontinent

GEOCHEMISTRY AND ORIGIN OF THE EASTERN SAYAN OPHIOLITES, TUVA-MONGOLIAN MICROCONTINENT (SOUTHERN SIBERIA)

The Eastern Sayan ophiolites (1020 Ma) of the Tuva-Mongolian microcontinent are believed to be the most ancient ophiolite of the Central Asian Orogenic Belt [Khain et al., 2002].The Eastern Sayan ophiolites (1020 Ma) of the Tuva-Mongolian microcontinent are believed to be the most ancient ophiolite of the Central Asian Orogenic Belt [Khain et al., 2002]

Correlation between emotional and social intelligence among first-year medical students

The purpose of the study is to identify the relationship between emotional and social intelligence in first-year medical students.Цель исследования – выявить взаимосвязь эмоционального и социального интеллектов у студентов-медиков первого курса

Clinical-epidemiological features and improvement of botulism laboratory diagnos-102 tics in Irkutsk region

Irkutsk Region is one of the Russian Regions where botulism cases are registered yearly. Botulism morbidity in Irkutsk Region is analysed for the ten-year period (since 2002); its clinical-epidemiological features are revealed at the present stage. Sporadic cases of botulism, are dominated. (81,9 %). From. 2006 in Irkutsk Region botulism share makes 100 % in food poisoning number. A considerable role in the infection transmission plays consumption of fish, mainly smoked or salty Baikal omul (90,9 %). In 30 % of cases injured people purchased fish at private persons in unascertained trade places, 60 % of patients ate own salting fish. In Irkutsk Region botulism is registered more often from July till November with peaks in July (58,3 %) and. September (20,8 %) that is connected, with activation of unprofitable fabricated fish selling in combination, with adverse conditions of this foodstuff storage. Botulism affects various age groups of population with, prevalence of the age category 30-49 years old. (47,8 %). Socially active able-bodied population. (72,3 %) is most often affected that increases the social importance of the disease. Mainly, moderate severe (56, 5 %) and. severe (34,8 %) disease forms were registered. Primary symptoms include two variants - dyspeptically-paralytic and. ophthalmologic-neurological forms. Analysis of botulism etiological structure showed, that the leading part in the disease occurrence in Irkutsk Region belonged to botulinum. type Е (73, 9 %). Clinical material and. foodstuff testing to botulinum toxin presence was conducted in parallel by the standard reaction of biological toxin neutralisation in white mice and dot-immunoanalysis with application of the test system that we have developed. Possibility of dot-immunoassay application in laboratory diagnostics of botulism is estimated as the express method with high specificity, sensitivity and. simplicity

Pharmacogenetic Warfarin Dosing Algorithm in the Russian Population

Background. To date, there are many pharmacogenetic algorithms for selecting the dose of warfarin. However, there is very little information about the predictive accuracy of the algorithms. We decided to evaluate the predictive accuracy of the Gage algorithm, using a calculator, located on the web site (http://www.warfarindosing.org) in two ethnic groups (Caucasians and Asians), living in Russia.Aim. To compare the actual warfarin dose (AWD) to the calculated warfarin dose (CWD), using the algorithm in two ethnic groups taking warfarin.Materials and methods. We included 114 patients (66 Caucasians and 48 Asians): the mean age was60.91 ± 12.34 years; 61 (53.51 %) men, and 53 (46.49 %) women. The comparative characteristics of the algorithm were tested using the mean absolute error (MAE) between AWD and CWD, and percentage of patients, whose CWD fell within 20 % of AWD (percentage within 20 %). Genotyping for CYP2C9*2, CYP2C9*3, CYP4F*2 and VKORC1 was performed by real-time polymerase chain reaction (RT-PCR) method using Pharmacogenetics Warfarin reagent kits (DNA technology, Russia).Results. The Gage algorithm produced the predictive accuracy with MAE = 1.02 ± 0.16 mg/day and percentage within 20 % for Asian patients was 39.6 %. We obtained MAE = 1.33 ± 0.16 mg/day and percentage within 20 % for Caucasian patients was 40.9 %. In two ethnic groups (Caucasians and Asians) of the Russian population, overall performance of warfarin pharmacogenetic dosing by the Gage algorithm was similar.Conclusions. Despite the performance limitation of the current warfarin pharmacogenetic dosing Gage algorithm, constant international normalized ratio monitoring is important

FREQUENCIES OF POLYMORPHISMS IN THE CYTOCHROME’S P450 GENES OF WARFARIN TRANSFORMATION IN A EUROPEAN POPULATION OF EASTERN SIBERIA

Background. Genotypes of the cytochrome p450 isoform (CYP2C9 and CYP4F2) determine warfarin dose requirements. Frequencies of risk alleles and genotypes of CYP2C9 and CYP4F2 gene vary in different races and ethnic groups.Aim. This study analyzed the frequencies of *2, *3 alleles of CYP2C9 gene and the 1347 C>T allele of CYP4F2 gene in the Caucasians of Eastern Siberia, and compare with other populations.Materials and methods. Participants were 147 patients (Caucasians): 67 (45.58 %) man and 80 (54.42 %) women), taking warfarin for the prevention of thrombosis with a mean age of 64.74 ± 14.29 years. There were patients with atrial fibrillation – 77 (52.38 %) persons, coronary artery disease – 10 (6.80 %), pulmonary embolism – 5 (3.40 %), 15 (10.20 %) patients after implantation of an mechanical heart valve, etc. The subjects were genotyped for CYP2C9 (*1,*2,*3), and CYP4F2 (1347 C>T) by real-time polymerase chain reaction (RT-PCR) using “Pharmacogenetics Warfarin” reagent kits (DNA technology, Russia).Results. 69.4 % of Caucasians of Eastern Siberia (Russians), have two functional alleles (*1/*1) of CYP2C9 (they’re extensive/normal metabolizers), the number of intermediate metabolizers (*1/*2, *1/*3) was 29.8 % and 0.68 % of slow metabolizers (*3/*3). Homozygous carriers of two non-functional alleles *2 and *3 (*2/*2, *2/*3) were absent. Carriers of one coumarin-resistant Т-allele of CYP4F2 were 57 (38.7 %) respondents, two coumarin-resistant alleles – 10 (6.8 %) respondents.Conclusions. Frequencies of polymorphisms in the Cytochrome’s p450 genes of warfarin transformation in a European population of Eastern Siberia have no differences with other European populations of the worl

Молекулярная и кристаллическая структура мезоморфных ароматических сложных эфиров.

n-Ethoxyphenyl-n'-pentylbenzoate was studied by X-ray diffraction analysis at 120.0 and 296.0 K. We have got any information in mutual orientation of the benzene rings and their possible conjugation the carboxy group COO, and orientation of the nearest benzene ringsМетодом РСА при 120,0 K и 296,0 K исследован п-этоксифенил-п´- пентилбензоат (1), обладающий мезофазой. Установлено взаимное расположение и наличие сопряжения бензольных колец и карбоксильной группы и ориентация бензольных колец соседних молекул. ВВ

Mechanical Characteristics of Myosin in Different Heart Chambers of Rats

The sliding velocity of the reconstituted thin filaments over atrial and ventricular myosin was measured using an in vitro motility assay. Mechanical characteristics of the actin-myosin interaction depends on heart chamber. Rats of the same breed, but of different origin, may have a different ratio.Работа выполнена на оборудовании ЦКП ИИФ УрО РАН в рамках госзадания ИИФ Уро РАН №122022200089-4