7 research outputs found
Palladium-Catalyzed Insertion of <i>N</i>‑tosylhydrazones and Trapping with Carbon Nucleophiles
A Pd-catalyzed three-component cross-coupling reaction of vinyl iodide, <i>N</i>-tosylhydrazone, and carbon nucleophiles is reported, and a one-pot procedure is also developed. The cross-coupling is proposed to proceed through a palladium–carbene migratory insertion, carbopalladation other than classic palladium–carbene migratory insertion, and β-H elimination. Moreover, the reaction proceeds under mild conditions and with high stereoselectivity
Brønsted Acid Catalyzed and NIS-Promoted Cyclization of Diynones: Selective Synthesis of 4‑Pyrone, 4‑Pyridone, and 3‑Pyrrolone Derivatives
Brønsted
acid catalyzed tandem cyclization was found to be
highly effective for the preparation of a series of polysubstituted
4-pyrones from diynones (yield up to 99%). 4-Pyridone and 3-pyrrolone
derivatives were also selectively synthesized by employing NIS and/or
Brønsted acid. NIS as an electrophilic reagent could promote
these reactions efficiently and rapidly under very mild reaction conditions
Brønsted Acid Catalyzed and NIS-Promoted Cyclization of Diynones: Selective Synthesis of 4‑Pyrone, 4‑Pyridone, and 3‑Pyrrolone Derivatives
Brønsted
acid catalyzed tandem cyclization was found to be
highly effective for the preparation of a series of polysubstituted
4-pyrones from diynones (yield up to 99%). 4-Pyridone and 3-pyrrolone
derivatives were also selectively synthesized by employing NIS and/or
Brønsted acid. NIS as an electrophilic reagent could promote
these reactions efficiently and rapidly under very mild reaction conditions
Brønsted Acid Catalyzed and NIS-Promoted Cyclization of Diynones: Selective Synthesis of 4‑Pyrone, 4‑Pyridone, and 3‑Pyrrolone Derivatives
Brønsted
acid catalyzed tandem cyclization was found to be
highly effective for the preparation of a series of polysubstituted
4-pyrones from diynones (yield up to 99%). 4-Pyridone and 3-pyrrolone
derivatives were also selectively synthesized by employing NIS and/or
Brønsted acid. NIS as an electrophilic reagent could promote
these reactions efficiently and rapidly under very mild reaction conditions
Brønsted Acid Catalyzed and NIS-Promoted Cyclization of Diynones: Selective Synthesis of 4‑Pyrone, 4‑Pyridone, and 3‑Pyrrolone Derivatives
Brønsted
acid catalyzed tandem cyclization was found to be
highly effective for the preparation of a series of polysubstituted
4-pyrones from diynones (yield up to 99%). 4-Pyridone and 3-pyrrolone
derivatives were also selectively synthesized by employing NIS and/or
Brønsted acid. NIS as an electrophilic reagent could promote
these reactions efficiently and rapidly under very mild reaction conditions
Palladium-Catalyzed Acylation/Alkenylation of Aryl Iodide: A Domino Approach Based on the Catellani–Lautens Reaction
A new
palladium-catalyzed three-component coupling involving acylation/alkenylation
of aryl iodide is reported. The reaction was carried out with readily
available starting materials and gave the ortho-acylated styrene in
moderate to good yields. Compared with previous Catellani–Lautens
reactions, this reaction
is the first example of introducing an acyl group at the ortho position
of aryl iodides. The proposed Pd<sup>IV</sup> complex, generated via
oxidative addition of the carboxylic anhydrides, is a key intermediate
for this transformation
Palladium-Catalyzed/Norbornene-Mediated <i>ortho</i>-Amination/<i>N</i>‑Tosylhydrazone Insertion Reaction: An Approach to the Synthesis of <i>ortho</i>-Aminated Vinylarenes
<i>ortho</i>-Aminated vinylarene derivatives were obtained
via a reaction of aryl iodides, <i>N</i>-benzoyloxyamines,
and <i>N</i>-tosylhydrazones. This approach involves a palladium-catalyzed,
norbornene-mediated <i>ortho</i>-amination/<i>N</i>-tosylhydrazone insertion reaction. In this transformation, one C–N
bond and one C–C bond are formed and an amine group is introduced
at the <i>ortho</i> position successfully