1,367 research outputs found

    Learner, customer or ambassador? : identity constructions of overseas students in the discourse of entrepreneurialism

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    In this thesis, I examine overseas students' identity construction in the context of\ud entrepreneurial discourse in relation to the way that the UK government, UK higher\ud education institutions, and university staff and overseas students interact with one\ud another.\ud Overseas students' identity is multifaceted. I am interested in how overseas\ud students' learner and customer identities are constructed and reconstructed in the\ud process of negotiating entrepreneurialism and its interrelated and competing\ud discourses, such as such as OSs as learners, OSs as customers, OSs as change\ud agents and OSs as ambassadors.\ud My empirical research is carried out as qualitative research drawing on\ud ethnographic approaches, and conducted in four UK universities. I interviewed\ud more than 50 postgraduate overseas students and 22 university staff at different\ud levels across universities. My analytical scope is influenced both by interactionism\ud and poststructural concepts of discourses and ideas, emphasising the micro/macro\ud links, rather than posing a dichotomy between micro/macro analytical levels.\ud My central argument is that the ways in which university staff negotiate the notions\ud of 'learner' and 'customer' influence overseas students' identity constructions. The\ud hidden debates on overseas students' learner and customer identities were latently\ud entwined with the construction of overseas students as victims, as problems and\ud as beneficiaries of the marketisation of higher education. These hidden debates\ud illuminate challenges which overseas students have to overcome, when they resist\ud and negotiate their learner and customer identities. My research should\ud counterbalance the one-sided and distorted perspective of overseas students,\ud particularly made by the media, which portrays them as sources of income as well\ud as sources of problems for the UK universities

    Discussion on study of knowledge creation, innovation ability and organizational performance for high-tech industries in Taiwan

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    Taiwan's high-tech industry face intense global competitive environment, strengthening the capacity of its own through the creation of high-quality organizational performance has been the key focus of many studies. This study investigated the creation of knowledge and organizational performance. Information and communication, and electronic products within the high-tech knowledge-intensive industries were selected for this study. The overall effect is concerned, is not knowledge creation, innovation and organizational performance individually influence means that high-tech industries, organizations. Whether knowledge creation, innovation and organizational performance influence means that high-tech industries, organizations to enhance business performance created by knowledge began its maximum effectiveness

    EFFECTS OF WHOLE BODY VIBRATION TRAINING ON KNEE EXTENSOR MUSCLE STRENGTH AND RATE OF FORCE DEVELOPMENT

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    This study compared the effects of 8-week whole-body vibration (WBV) training programs on knee extensor muscle strength and rate of force development. Twenty physically active male subjects were randomly assigned to a whole-body vibration training group (WBV; n =10) or a sham training group (SHAM; n = 10). Maximal voluntary isometric joint moment, rate of force development (RFD) and contractile impulse of the knee extensors were assessed before and after the training period. There were significant differences between WBV and sham groups on improvement percentage of maximum joint moment, RFD and contractile impulse in knee extensor. We concluded that not only knee extensor muscle strength could be enhanced but also muscle contractile abilty could be faster after a 8-week WBV training program

    Growth rate regulation of lac operon expression in Escherichia coli is cyclic AMP dependent

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    AbstractIn contrast to the ribosomal RNA gene expression increasing with growth rate, transcription of the lac operon is downregulated by cell growth rate. In continuous culture, growth rate regulation of lac promoter was independent of carbon substrate used and its location on the chromosome. Since the lac operon is activated by cyclic adenosine monophosphate (cAMP), which decreases with increasing cell growth rate, expression of plac-lacZ reporter fusion was analyzed in cya mutant under various growth conditions. The results demonstrated that expression of plac-lacZ in cya mutant was both lower and growth rate independent. In addition, ppGpp (guanosine tetraphosphate) was not involved in the mechanism of growth rate regulation of the lac promoter. Thus, the results of this study indicate that cAMP mediates the growth rate-dependent regulation of lac operon expression in Escherichia coli

    Utilized mass spectrometry-based protein profiling system to identify potential biomarkers of hepatocellular carcinoma

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    AbstractHepatocellular carcinoma (HCC) is the most common malignant liver tumor. The purpose of this study is to characterize proteins secreted from the HepG2 cells, which may relate to cell differentiation and tumor metastasis. In the proteomic analysis, the secretome was identified by nano-high–performance liquid chromatography/electrospray ionization tandem mass spectrometry (nano-HPLC/ESIMS/MS) followed by peptide fragmentation pattern analysis. In this study, three proteins, p130Cas-associated protein (p130Cas/BCAR1), TAR DNA-binding protein 43 (TDP43/TARDBP) and translationally controlled tumor protein (TCTP/TPT1), were identified and confirmed by Western blotting, which showed significantly differential expression compared with the normal liver cells. Analyzing differential protein expressions in HepG2 cell by proteomic approaches suggests that p130Cas/BCAR1, TDP43/TARDBP and TCTP/TPT1 as key proteins and may serve as biomarkers for HCC

    Foreground Subtraction in Intensity Mapping with the SKA

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    21cm intensity mapping experiments aim to observe the diffuse neutral hydrogen (HI) distribution on large scales which traces the Cosmic structure. The Square Kilometre Array (SKA) will have the capacity to measure the 21cm signal over a large fraction of the sky. However, the redshifted 21cm signal in the respective frequencies is faint compared to the Galactic foregrounds produced by synchrotron and free-free electron emission. In this article, we review selected foreground subtraction methods suggested to effectively separate the 21cm signal from the foregrounds with intensity mapping simulations or data. We simulate an intensity mapping experiment feasible with SKA phase 1 including extragalactic and Galactic foregrounds. We give an example of the residuals of the foreground subtraction with a independent component analysis and show that the angular power spectrum is recovered within the statistical errors on most scales. Additionally, the scale of the Baryon Acoustic Oscillations is shown to be unaffected by foreground subtraction.Comment: This article is part of the 'SKA Cosmology Chapter, Advancing Astrophysics with the SKA (AASKA14), Conference, Giardini Naxos (Italy), June 9th-13th 2014

    Consistency of genetic inheritance mode and heritability patterns of triglyceride vs. high density lipoprotein cholesterol ratio in two Taiwanese family samples

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    BACKGROUND: Triglyceride/HDL cholesterol ratio (TG/HDL-C) is considered as a risk factor for cardiovascular events. Genetic components were important in controlling the variation in western countries. But the mode of inheritance and family aggregation patterns were still unknown among Asian-Pacific countries. This study, based on families recruited from community and hospital, is aimed to investigate the mode of inheritance, heritability and shared environmental factors in controlling TG/HDL-C. RESULTS: Two populations, one from community-based families (n = 988, 894 parent-offspring and 453 sibling pairs) and the other from hospital-based families (n = 1313, 76 parent-offspring and 52 sibling pairs) were sampled. The population in hospital-based families had higher mean age values than community-based families (54.7 vs. 34.0). Logarithmic transformed TG/ HDL-C values, after adjusted by age, gender and body mass index, were for genetic analyses. Significant parent-offspring and sibling correlations were also found in both samples. The parent-offspring correlation coefficient was higher in the hospital-based families than in the community-based families. Genetic heritability was higher in community-based families (0.338 ± 0.114, p = 0.002), but the common shared environmental factor was higher in hospital-based families (0.203 ± 0.042, p < 0.001). Commingling analyses showed that more than one-component distribution models were the best-fit models to explain the variance in both populations. Complex segregation analysis by regressive models revealed that in both samples the best-fit model of TG/HDL-C was the model of environmental effects plus familial correlation, in which significant parent-offspring and sibling correlations were demonstrated. Models of major gene effects were rejected in both samples. CONCLUSION: Variations of TG/HDL-C in the normal ranges were likely to be influenced by multiple factors, including environmental and genetic components. Higher genetic factors were proved in younger community-based families than in older hospital-based families

    The Methanolic Extract of Perilla frutescens Robustly Restricts Ebola Virus Glycoprotein-Mediated Entry

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    Ebola virus (EBOV), one of the most infectious human viruses and a leading cause of viral hemorrhagic fever, imposes a potential public health threat with several recent outbreaks. Despite the difficulties associated with working with this pathogen in biosafety level-4 containment, a protective vaccine and antiviral therapeutic were recently approved. However, the high mortality rate of EBOV infection underscores the necessity to continuously identify novel antiviral strategies to help expand the scope of prophylaxis/therapeutic management against future outbreaks. This includes identifying antiviral agents that target EBOV entry, which could improve the management of EBOV infection. Herein, using EBOV glycoprotein (GP)-pseudotyped particles, we screened a panel of natural medicinal extracts, and identified the methanolic extract of Perilla frutescens (PFME) as a robust inhibitor of EBOV entry. We show that PFME dose-dependently impeded EBOV GP-mediated infection at non-cytotoxic concentrations, and exerted the most significant antiviral activity when both the extract and the pseudoparticles are concurrently present on the host cells. Specifically, we demonstrate that PFME could block viral attachment and neutralize the cell-free viral particles. Our results, therefore, identified PFME as a potent inhibitor of EBOV entry, which merits further evaluation for development as a therapeutic strategy against EBO
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