7,546 research outputs found
Sentiment Recognition in Egocentric Photostreams
Lifelogging is a process of collecting rich source of information about daily
life of people. In this paper, we introduce the problem of sentiment analysis
in egocentric events focusing on the moments that compose the images recalling
positive, neutral or negative feelings to the observer. We propose a method for
the classification of the sentiments in egocentric pictures based on global and
semantic image features extracted by Convolutional Neural Networks. We carried
out experiments on an egocentric dataset, which we organized in 3 classes on
the basis of the sentiment that is recalled to the user (positive, negative or
neutral)
A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells
Viral mutational escape can reduce or abrogate recognition by the T cell receptor (TCR) of virus-specific CD8+ T cells. However, very little is known about the impact of cytotoxic T lymphocyte (CTL) epitope mutations on interactions between peptide–major histocompatibility complex (MHC) class I complexes and MHC class I receptors expressed on other cell types. Here, we analyzed a variant of the immunodominant human leukocyte antigen (HLA)-B2705–restricted HIV-1 Gag KK10 epitope (KRWIILGLNK) with an L to M amino acid substitution at position 6 (L6M), which arises as a CTL escape variant after primary infection but is sufficiently immunogenic to elicit a secondary, de novo HIV-1–specific CD8+ T cell response with an alternative TCR repertoire in chronic infection. In addition to altering recognition by HIV-1–specific CD8+ T cells, the HLA-B2705–KK10 L6M complex also exhibits substantially increased binding to the immunoglobulin-like transcript (ILT) receptor 4, an inhibitory MHC class I–specific receptor expressed on myelomonocytic cells. Binding of the B2705–KK10 L6M complex to ILT4 leads to a tolerogenic phenotype of myelomonocytic cells with lower surface expression of dendritic cell (DC) maturation markers and co-stimulatory molecules. These data suggest a link between CTL-driven mutational escape, altered recognition by innate MHC class I receptors on myelomonocytic cells, and functional impairment of DCs, and thus provide important new insight into biological consequences of viral sequence diversificatio
On electromagnetic interactions for massive mixed symmetry field
In this paper we investigate electromagnetic interactions for simplest
massive mixed symmetry field. Using frame-like gauge invariant formulation we
extend Fradkin-Vasiliev procedure, initially proposed for investigation of
gravitational interactions for massless particles in AdS space, to the case of
electromagnetic interactions for massive particles leaving in (A)dS space with
arbitrary value of cosmological constant including flat Minkowski space. At
first, as an illustration of general procedure, we re-derive our previous
results on massive spin 2 electromagnetic interactions and then we apply this
procedure to massive mixed symmetry field. These two cases are just the
simplest representatives of two general class of fields, namely completely
symmetric and mixed symmetry ones, and it is clear that the results obtained
admit straightforward generalization to higher spins as well.Comment: 17 pages. Some clarifications added. Version to appear in JHE
Spin 3 cubic vertices in a frame-like formalism
Till now most of the results on interaction vertices for massless higher spin
fields were obtained in a metric-like formalism using completely symmetric
(spin-)tensors. In this, the Lagrangians turn out to be very complicated and
the main reason is that the higher the spin one want to consider the more
derivatives one has to introduce. In this paper we show that such
investigations can be greatly simplified if one works in a frame-like
formalism. As an illustration we consider massless spin 3 particle and
reconstruct a number of vertices describing its interactions with lower spin 2,
1 and 0 ones. In all cases considered we give explicit expressions for the
Lagrangians and gauge transformations and check that the algebra of gauge
transformations is indeed closed.Comment: 17 pades, no figure
Self-rated health in middle-aged and elderly Chinese : distribution, determinants and associations with cardio-metabolic risk factors
Background: Self-rated health (SRH) has been demonstrated to be an accurate reflection of a person's health and a valid predictor of incident mortality and chronic morbidity. We aimed to evaluate the distribution and factors associated with SRH and its association with biomarkers of cardio-metabolic diseases among middle-aged and elderly Chinese.
Methods: Survey of 1,458 men and 1,831 women aged 50 to 70 years, conducted in one urban and two rural areas of Beijing and Shanghai in 2005. SRH status was measured and categorized as good (very good and good) vs. not good (fair, poor and very poor). Determinants of SRH and associations with biomarkers of cardio-metabolic diseases were evaluated using logistic regression.
Results: Thirty two percent of participants reported good SRH. Males and rural residents tended to report good SRH. After adjusting for potential confounders, residence, physical activity, employment status, sleep quality and presence of diabetes, cardiovascular disease, and depression were the main determinants of SRH. Those free from cardiovascular disease (OR 3.68; 95%CI 2.39; 5.66), rural residents (OR 1.89; 95% CI 1.47; 2.43), non-depressed participants (OR 2.50; 95% CI 1.67; 3.73) and those with good sleep quality (OR 2.95; 95% CI 2.22; 3.91) had almost twice or over the chance of reporting good SRH compared to their counterparts. There were significant associations -and trend- between SRH and levels of inflammatory markers, insulin levels and insulin resistance.
Conclusion: Only one third of middle-aged and elderly Chinese assessed their health status as good or very good. Although further longitudinal studies are required to confirm our findings, interventions targeting social inequalities, lifestyle patterns might not only contribute to prevent chronic morbidity but as well to improve populations' perceived health
Roaring high and low: composition and possible functions of the Iberian stag's vocal repertoire
We provide a detailed description of the rutting vocalisations of free-ranging male Iberian deer (Cervus elaphus hispanicus, Hilzheimer 1909), a geographically isolated and morphologically differentiated subspecies of red deer Cervus elaphus. We combine spectrographic examinations, spectral analyses and automated classifications to identify different call types, and
compare the composition of the vocal repertoire with that of other red deer subspecies. Iberian stags give bouts of roars (and more rarely, short series of barks) that are typically composed of two different types of calls. Long Common Roars are mostly given at the beginning or at the end of the bout, and are characterised by a high fundamental frequency (F0) resulting in poorly defined formant frequencies but a relatively high amplitude. In contrast, Short Common Roars are typically given in the middle or at the end of the bout, and are characterised by a lower F0 resulting in relatively well defined vocal tract resonances, but low amplitude. While we did not identify entirely Harsh Roars (as described in the Scottish red
deer subspecies (Cervus elaphus scoticus), a small percentage of Long Common Roars contained segments of deterministic chaos. We suggest that the evolution of two clearly distinct types of Common Roars may reflect divergent selection pressures favouring either vocal efficiency in high pitched roars or the communication of body size in low-pitched, high spectral density roars highlighting vocal tract resonances. The clear divergence of the Iberian red deer vocal repertoire from those of other documented European red deer populations reinforces the status of this geographical variant as a distinct subspecies
Searching for Exoplanets Using a Microresonator Astrocomb
Detection of weak radial velocity shifts of host stars induced by orbiting
planets is an important technique for discovering and characterizing planets
beyond our solar system. Optical frequency combs enable calibration of stellar
radial velocity shifts at levels required for detection of Earth analogs. A new
chip-based device, the Kerr soliton microcomb, has properties ideal for
ubiquitous application outside the lab and even in future space-borne
instruments. Moreover, microcomb spectra are ideally suited for astronomical
spectrograph calibration and eliminate filtering steps required by conventional
mode-locked-laser frequency combs. Here, for the calibration of astronomical
spectrographs, we demonstrate an atomic/molecular line-referenced,
near-infrared soliton microcomb. Efforts to search for the known exoplanet HD
187123b were conducted at the Keck-II telescope as a first in-the-field
demonstration of microcombs
The scale of population structure in Arabidopsis thaliana
The population structure of an organism reflects its evolutionary history and influences its evolutionary trajectory. It constrains the combination of genetic diversity and reveals patterns of past gene flow. Understanding it is a prerequisite for detecting genomic regions under selection, predicting the effect of population disturbances, or modeling gene flow. This paper examines the detailed global population structure of Arabidopsis thaliana. Using a set of 5,707 plants collected from around the globe and genotyped at 149 SNPs, we show that while A. thaliana as a species self-fertilizes 97% of the time, there is considerable variation among local groups. This level of outcrossing greatly limits observed heterozygosity but is sufficient to generate considerable local haplotypic diversity. We also find that in its native Eurasian range A. thaliana exhibits continuous isolation by distance at every geographic scale without natural breaks corresponding to classical notions of populations. By contrast, in North America, where it exists as an exotic species, A. thaliana exhibits little or no population structure at a continental scale but local isolation by distance that extends hundreds of km. This suggests a pattern for the development of isolation by distance that can establish itself shortly after an organism fills a new habitat range. It also raises questions about the general applicability of many standard population genetics models. Any model based on discrete clusters of interchangeable individuals will be an uneasy fit to organisms like A. thaliana which exhibit continuous isolation by distance on many scales
Effect of temperature anisotropy on various modes and instabilities for a magnetized non-relativistic bi-Maxwellian plasma
Using kinetic theory for homogeneous collisionless magnetized plasmas, we
present an extended review of the plasma waves and instabilities and discuss
the anisotropic response of generalized relativistic dielectric tensor and
Onsager symmetry properties for arbitrary distribution functions. In general,
we observe that for such plasmas only those electromagnetic modes whose
magnetic field perturbations are perpendicular to the ambient magneticeld,
i.e.,B1 \perp B0, are effected by the anisotropy. However, in oblique
propagation all modes do show such anisotropic effects. Considering the
non-relativistic bi-Maxwellian distribution and studying the relevant
components of the general dielectric tensor under appropriate conditions, we
derive the dispersion relations for various modes and instabilities. We show
that only the electromagnetic R- and L- waves, those derived from them and the
O-mode are affected by thermal anisotropies, since they satisfy the required
condition B1\perpB0. By contrast, the perpendicularly propagating X-mode and
the modes derived from it (the pure transverse X-mode and Bernstein mode) show
no such effect. In general, we note that the thermal anisotropy modifies the
parallel propagating modes via the parallel acoustic effect, while it modifies
the perpendicular propagating modes via the Larmor-radius effect. In oblique
propagation for kinetic Alfven waves, the thermal anisotropy affects the
kinetic regime more than it affects the inertial regime. The generalized fast
mode exhibits two distinct acoustic effects, one in the direction parallel to
the ambient magnetic field and the other in the direction perpendicular to it.
In the fast-mode instability, the magneto-sonic wave causes suppression of the
firehose instability. We discuss all these propagation characteristics and
present graphic illustrations
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