1,515 research outputs found
Giant Gating Tunability of Optical Refractive Index in Transition Metal Dichalcogenide Monolayers
We report that the refractive index of transition metal dichacolgenide (TMDC)
monolayers, such as MoS2, WS2, and WSe2, can be substantially tuned by > 60% in
the imaginary part and > 20% in the real part around exciton resonances using
CMOS-compatible electrical gating. This giant tunablility is rooted in the
dominance of excitonic effects in the refractive index of the monolayers and
the strong susceptibility of the excitons to the influence of injected charge
carriers. The tunability mainly results from the effects of injected charge
carriers to broaden the spectral width of excitonic interband transitions and
to facilitate the interconversion of neutral and charged excitons. The other
effects of the injected charge carriers, such as renormalizing bandgap and
changing exciton binding energy, only play negligible roles. We also
demonstrate that the atomically thin monolayers, when combined with photonic
structures, can enable the efficiencies of optical absorption (reflection)
tuned from 40% (60%) to 80% (20%) due to the giant tunability of refractive
index. This work may pave the way towards the development of field-effect
photonics in which the optical functionality can be controlled with CMOS
circuits
On Local Solutions of Second Order Quasi-linear Elliptic Systems with Arbitrary 1-Jet at a Point
We prove a general result on the existence of local solutions of any second
order quasi-linear elliptic system with arbitrary 1-jet at a point
Construction of Twice Differentiable Functions with Continuous Laplacian and Bounded Hessian
We construct examples of twice differentiable functions in
with continuous Laplacian and bounded Hessian. The same construction is also
applicable to higher order differentiability, the Monge-Amp\`ere equation, and
mean curvature equation for hypersurfaces
Irbesartan protects against type 2 diabetic nephropathy by regulating miR-93/VEGF and its downstream effectors
Purpose: To investigate the protective effect of irbesartan against type 2 diabetic nephropathy (T2DN), and the mechanism involved.Methods: Wistar rats (n = 48) were used in this study. Diabetes mellitus (DM) was established in the rats via injection of streptozotocin (STZ). Thereafter, the DM rats were randomly divided into diabetic nephropathy (DN) group and irbesartan group, with 16 rats in each group. Rats in the control group (n = 16) received normal saline in place of irbesartan.Results: Total cholesterol (TC), triglycerides (TGs), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C), as well as protein expression levels of VEGF, FN, collagen IV in DN group were significantly higher in irbesartan group than the corresponding levels in normal control group, while miR-93 protein expression level was significantly lower than that in normal control group (p < 0.05). However, the expression level of mir-93 was significantly higher in irbesartan group than in DN group, while levels of TC, TGs, HDL-C, LDL-C and VEGF, as well as protein levels of FN and collagen IV protein were significantly lower than those in DN group (p < 0.05). There was no obvious change in the renal tissues of the normal control group. In contrast, in the DN group, glomerularcapillary loop hypertrophy, narrow glomerular cavity, thick basement membrane, mesangial matrix, and vacuolar degeneration in renal tubular epithelial cells, were evident. Compared with DN group, the pathological changes in the irbesartan group were significantly mitigated (p < 0.05).Conclusion: Irbesartan protects DM rats against type 2 diabetic nephropathy by regulating mir-93/VEGF and its downstream effector molecules. This provides some ideas for the development of new drugs for the prevention of type 2 diabetic nephropathy
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