Future prospects and application for the development of adenovirus-based vaccine

Ebola viruses (EBOVs) are enveloped, non-segmented, negative-strand RNA viruses belonging to the family Filoviridae. They are known to cause lethal hemorrhagic fever in humans with a mortality rate up to 90%. As an emergency response to the largest Ebola disease epidemic in 2014, several countries had accelerated the process of developing effective vaccines against Ebola. The vaccine described here, unlike other Ebola vaccine candidates that are under clinical evaluation, is the first Ebola vaccine based on the 2014 Zaire Guinea epidemic strain. This vaccine, Ad5-EBOV, is a replication-defective recombinant human type 5 adenovirus expressing Zaire (Makona, 2014) Ebola virus envelope glycoprotein. A manufacturing process, up to 200L scale, has been developed and optimized. The purified Ad5-EBOV was formulated with the addition of proper stabilizers and lyophilized. The product can be stored at 2 – 8oC for at least one year without losing any infectivity. The Ad5-EBOV vaccine was tested in guinea pig and non-human primate models. In both cases, it was showed to elicit specific B- and T-cell immunity and conferred 100% protection when animals were challenged with the Ebola virus. Following two successful phase I trials in China, a phase II trial of Ad5-EBOV was conducted in Sierra Leone in 2015 with 500 participants. The results of the trials demonstrated that Ad5-EBOV is safe and highly immunogenic

Crazyseismic: A MATLAB GUI‐Based Software Package for Passive Seismic Data Preprocessing

We introduce an open‐source MATLAB software package, named Crazyseismic, for passive seismic data preprocessing. Built‐in core functions such as seismic phase travel‐time calculation and multichannel cross correlation significantly improve the efficiency of data processing. Compared with conventional command‐line‐style toolboxes, all functions in Crazyseismic are embedded in one single graphic user interface (GUI). The human–machine interactive nature of GUI facilitates data quality control. The simplicity of the software allows users to process Seismic Analysis Code format seismic data with great ease and also provides a means by which users can tailor the software for their specific needs. We demonstrate the power of our software through two field examples: one for P‐wave arrival‐time picking and the other for receiver function calculation. The software can essentially be used for analyzing all major body‐wave phases in seismology

Spurious Relationship of AR(P) Stable Sequences in Presence of Trends Breaks

This paper analyzes spurious regression phenomenon involving AR(p) stable processes with trend breaks. It shows that when those time series are used in ordinary least squares regression, the convenient t-ratios procedures wrongly indicate that the spurious relationship is present as the pair of independent stable series contains trend changes. The spurious relationship becomes stronger as the sample size approaches to infinite. As a result, spurious effects might occur more often than we previously believed as they can arise even between AR(p) stable series in present of trend breaks

Cloud-structural health monitoring based on smartphone

Smartphone, integrated with CPU, sensors, network, and storage capability, is developed rapidly in recent years. A cloud-structural health monitoring method based on smartphone was proposed, and a structural health monitoring system Orion-CC, which integrates functions of data acquisition, data analysis and data upload, was developed on smartphone to perform structural health monitoring without any other professional devices. And the feasibility of Orion-CC was proved by the cable force test. A cloud-SHM data sharing website was built to make the data synchronization between smartphone and website, and realize data uploading and sharing, which can improve the efficiency of monitoring and big data integration, make the possibility for big data collection and quick structural safety evaluation

Smartphone based public participant emergency rescue information platform for earthquake zone – “E-Explorer”

Devastating earthquake can often cause the disaster area communication interrupt, traffic paralysis, etc. It is difficult for the emergency rescue force to get the disaster area in time. Therefore, active local participation in the quake-hit areas to aid each other appeals extremely important. The paper is based on a self-developed smartphone software called “E-Explorer”, study its significance and its working methods to help the public participate in the earthquake rescue actively when external network are cut off. “E-Explorer” can help deliver important information for personal survival, let rescue workers locate the positions of survivors trapped, creating an efficient self-help and mutual rescue platform for the earthquake-stricken people