Efficacy and patient-reported outcomes in advanced non-small cell lung cancer patients receiving aumolertinib as first-line therapy: a real-world study

BackgroundAumolertinib demonstrated superior progression-free survival (PFS) and a well-tolerated toxicity profile compared to gefitinib in front-line treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) in the AENEAS trial. However, patient-reported outcomes (PROs) of aumolertinib have not been published.MethodsIn this real-world study, the efficacy was evaluated by Response Evaluation Criteria in Solid Tumors (RECIST) 1.0. PROs were evaluated using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30 (QLQ-C30) and the EORTC Quality of Life lung cancer-specific module (QLQ-LC13) in advanced NSCLC patients receiving aumolertinib as initial therapy. Pre-specified key symptoms were cough, hemoptysis, dyspnea, sore mouth or tongue, dysphagia, hair loss, tingling in hands or feet, chest pain, arm or shoulder pain, and pain at other sites.ResultsA total of 33 patients were included, 23 of whom had efficacy information up to January 2024. The median follow-up time was 264 days (interval: 36–491 days). The objective response rate and disease control rate were 65.2% and 91.3%, respectively. The EORTC QLQ-LC30 general health status scale showed that functional scales increased and symptom scales decreased during aumolertinib treatment. Symptom scales assessed by the EORTC QLQ-LC13 showed that improvements in cough, sore mouth or tongue, tingling in hands or feet, chest pain, arm or shoulder pain, and other pain sites were both clinically and statistically significant after 6 months of aumolertinib treatment (p < 0.05).ConclusionIn this real-world study, aumolertinib showed comparable disease control and objective response rates as reported in the AENEAS trial for advanced NSCLC patients with EGFR-sensitizing mutations. Aumolertinib treatment improved PROs, further supporting it in first-line clinical practice

Human behavior-driven robotics and security

Abstract not currently available

Precise Estimation of Source Intensity for Wide-field Telescopes with PSF Modeling

Abstract Wide-field small aperture optical telescopes are widely used in large-scale surveys currently and they have made great contributions in a number of astronomical applications. However, specific challenges arise owing to the defects caused by the optical system, and the image quality and reduction precision are negatively affected. An innovative method is proposed to address these challenges and achieve a high-precision source intensity estimation. In implementation, first a dedicated pipeline is developed to investigate the point-spread function (PSF) components from large amounts of images, using principal component analysis. Then the PSF model that reveals the actual characteristics of the optical system is constructed based on the evaluation. Last the equations for centroid and intensity estimation are constructed and the results are obtained. A trial of observations is performed with a wide-field small aperture telescope, and a large number of raw images, as well as simulated images, are acquired to test the efficiency of our method. The intensity measurement is performed with our method and other common algorithms, including the modified moment, Gaussian fitting, and SExtractor. Based on the comparison it is demonstrated that our proposed method outperforms the others. The results indicate that our method explores the limitations of such a system and additional gains can be achieved in wider applications.</jats:p

Impact of Nitrite Supplementation on Bioactive Peptides during Sausage Processing

The goal of this investigation was to examine the impact of nitrite supplementation on the concentration, antioxidant properties, and species of antioxidant peptides in fermented sausages. The polypeptide concentration in nitrite-supplemented sausages was markedly elevated during sausage processing compared to the blank control (p p p < 0.05). Based on the liquid chromatograph-mass spectrometer (LC-MS) analysis of the sausage, LPGGGHGDL, TKYRVP, FLKMN, SAGNPN, GLAGA, LPGGGT, DLEE, GKFNV, GLAGA, AEEEYPDL, HCNKKYRSEM, TSNRYHSYPWG, and other polypeptides exhibited antioxidant properties. Moreover, the number of species of antioxidant polypeptides in the nitrite-supplemented sausage was greater in comparison to the controls. Based on this evidence, it may be concluded that nitrite supplementation positively modulated antioxidant polypeptide formation in fermented sausages, thereby providing strong evidence that nitrite supplementation significantly enhances sausage quality

Impact of Nitrite Supplementation on Bioactive Peptides during Sausage Processing

The goal of this investigation was to examine the impact of nitrite supplementation on the concentration, antioxidant properties, and species of antioxidant peptides in fermented sausages. The polypeptide concentration in nitrite-supplemented sausages was markedly elevated during sausage processing compared to the blank control (p &lt; 0.05). Moreover, nitrite supplementation in fermented sausages markedly enhanced the DPPH, as well as the ABTS, hydroxyl radical, and superoxide anion free radical scavenging abilities (FRSA) of polypeptides (p &lt; 0.05). The ferrous ion chelating ability was also significantly enhanced (p &lt; 0.05). Based on the liquid chromatograph-mass spectrometer (LC-MS) analysis of the sausage, LPGGGHGDL, TKYRVP, FLKMN, SAGNPN, GLAGA, LPGGGT, DLEE, GKFNV, GLAGA, AEEEYPDL, HCNKKYRSEM, TSNRYHSYPWG, and other polypeptides exhibited antioxidant properties. Moreover, the number of species of antioxidant polypeptides in the nitrite-supplemented sausage was greater in comparison to the controls. Based on this evidence, it may be concluded that nitrite supplementation positively modulated antioxidant polypeptide formation in fermented sausages, thereby providing strong evidence that nitrite supplementation significantly enhances sausage quality.</jats:p

Audit Committee Chair’s Geographic Distance and Cost of Equity Capital

Using a sample of A-share listed companies in China for the period of 2007-2018, this paper empirically tests the impact of the geographical distance of the audit committee chair (ACC) on the company’s cost of equity capital. The study found that there is a significant positive correlation between the geographical distance of ACC and the company’s cost of equity capital, and the regulatory strength will weaken the positive relationship between the two. This conclusion still holds after a series of robustness tests. The research conclusion of this paper not only enriches the research on the characteristics of audit committee chairs, expands the research extension of geographical economics in the field of financial accounting, but also provides certain theoretical support and test evidence for listed companies to select ACC and reduce the cost of equity capital. It is of great significance to improve the performance level of the audit committee and protect the interests of investors

Improving position accuracy for telescopes with small aperture and wide field of view utilizing point spread function modelling

ABSTRACT Telescopes with a small aperture and a wide field of view are widely used and play a significant role in large-scale state-of-the-art sky survey applications, such as transient detection and near-Earth object observations. However, owing to the specific defects caused by optical aberrations, the image quality and efficiency of source detection are affected. To achieve high-accuracy position measurements, an innovative technique is proposed. First, a large number of raw images are analysed using principal component analysis. Then, the effective point spread function is reconstructed, which reflects the state of the telescope and reveals the characteristics of the imaging process. Finally, based on the point spread function model, the centroids of star images are estimated iteratively. To test the efficiency and reliability of our algorithm, a large number of simulated images are produced, and a telescope with small aperture and wide field of view is utilized to acquire the raw images. The position measurement of sources is performed using our novel method and two other common methods on these data. Based on a comparison of the results, the improvement is investigated, and it is demonstrated that our proposed technique outperforms the others on position accuracy. We explore the limitations and potential gains that may be achieved by applying this technique to custom systems designed specifically for wide-field astronomical applications.</jats:p

Algorithms for surveying and cataloguing space debris utilizing a wide field of view telescope

Abstract Optical surveys using astronomical telescopes are an efficient way to observe and catalogue space debris, especially for detecting debris in medium or geostationary Earth orbits. Nowadays, small aperture and wide field of view telescopes are widely used and play significant roles in optical space debris surveys. However, special challenges arise since space debris is moving relatively to the background stars and the optics suffer from defects. This affects the efficiency of traditional source extraction methods. Here, a dedicated image processing technique is developed to automatically detect and measure space debris from consecutive CCD images. In order to improve the detection efficiency and robustness, several innovative algorithms are introduced to eliminate noise and increase the object detection ability, and the whole pipeline is optimized to reduce the raw images in real time. A trial survey with a wide field of view and small aperture telescope is presented to test our technique. In our survey, two observing strategies are adopted according to the dynamical features of space objects in the high Earth orbital region, and large numbers of raw CCD images are obtained for both strategies; the efficiency of our reduction is investigated based on the reduction results. Our technique exhibits a correlation rate higher than 97%, and around 400 objects can be routinely observed and catalogued just utilizing one wide field of view telescope in one night.</jats:p