4,876 research outputs found
Dynamics of methane ebullition from a peat monolith revealed from a dynamic flux chamber system
Methane (CH4) ebullition in northern peatlands is poorly quantified in part due to its high spatiotemporal variability. In this study, a dynamic flux chamber (DFC) system was used to continuously measure CH4 fluxes from a monolith of near‐surface Sphagnum peat at the laboratory scale to understand the complex behavior of CH4 ebullition. Coincident transmission ground penetrating radar measurements of gas content were also acquired at three depths within the monolith. A graphical method was developed to separate diffusion, steady ebullition, and episodic ebullition fluxes from the total CH4 flux recorded and to identify the timing and CH4 content of individual ebullition events. The results show that the application of the DFC had minimal disturbance on air‐peat CH4 exchange and estimated ebullition fluxes were not sensitive to the uncertainties associated with the graphical model. Steady and episodic ebullition fluxes were estimated to be averagely 36 ± 24% and 38 ± 24% of the total fluxes over the study period, respectively. The coupling between episodic CH4 ebullition and gas content within the three layers supports the existence of a threshold gas content regulating CH4 ebullition. However, the threshold at which active ebullition commenced varied between peat layers with a larger threshold (0.14 m3 m−3) observed in the deeper layers, suggesting that the peat physical structure controls gas bubble dynamics in peat. Temperature variation (23°C to 27°C) was likely only responsible for small episodic ebullition events from the upper peat layer, while large ebullition events from the deeper layers were most likely triggered by drops in atmospheric pressure
Smooth and Non-Smooth Dependence of Lyapunov Vectors upon the Angle Variable on a Torus in the Context of Torus-Doubling Transitions in the Quasiperiodically Forced Henon Map
A transition from a smooth torus to a chaotic attractor in quasiperiodically
forced dissipative systems may occur after a finite number of torus-doubling
bifurcations. In this paper we investigate the underlying bifurcational
mechanism which seems to be responsible for the termination of the
torus-doubling cascades on the routes to chaos in invertible maps under
external quasiperiodic forcing. We consider the structure of a vicinity of a
smooth attracting invariant curve (torus) in the quasiperiodically forced Henon
map and characterize it in terms of Lyapunov vectors, which determine
directions of contraction for an element of phase space in a vicinity of the
torus. When the dependence of the Lyapunov vectors upon the angle variable on
the torus is smooth, regular torus-doubling bifurcation takes place. On the
other hand, the onset of non-smooth dependence leads to a new phenomenon
terminating the torus-doubling bifurcation line in the parameter space with the
torus transforming directly into a strange nonchaotic attractor. We argue that
the new phenomenon plays a key role in mechanisms of transition to chaos in
quasiperiodically forced invertible dynamical systems.Comment: 24 pages, 9 figure
Genomic and biologic comparisons of cyprinid herpesvirus 3 strains
Cyprinid herpesvirus 3 (CyHV-3) is the archetypal fish alloherpesvirus and the etiologic agent of a lethal disease in common and koi carp. To date, the genome sequences of only four CyHV-3 isolates have been published, but no comparisons of the biologic properties of these strains have been reported. We have sequenced the genomes of a further seven strains from various geographical sources, and have compared their growth in vitro and virulence in vivo. The major findings were: (i) the existence of the two genetic lineages previously described as European and Asian was confirmed, but inconsistencies between the geographic origin and genotype of some strains were revealed; (ii) potential inter-lineage recombination was detected in one strain, which also suggested the existence of a third, as yet unidentified lineage; (iii) analysis of genetic disruptions led to the identification of non-essential genes and their potential role in virulence; (iv) comparison of the in vitro and in vivo properties of strains belonging to the two lineages revealed that inter-lineage polymorphisms do not contribute to the differences in viral fitness observed; and (v) a negative correlation was observed among strains between viral growth in vitro and virulence in vivo. This study illustrates the importance of coupling genomic and biologic comparisons of viral strains in order to enhance understanding of viral evolution and pathogenesis
Constraints on the perturbed mutual motion in Didymos due to impact-induced deformation of its primary after the DART impact
Binary near-Earth asteroid (65803) Didymos is the target of the proposed NASA
Double Asteroid Redirection Test (DART), part of the Asteroid Impact &
Deflection Assessment (AIDA) mission concept. In this mission, the DART
spacecraft is planned to impact the secondary body of Didymos, perturbing
mutual dynamics of the system. The primary body is currently rotating at a spin
period close to the spin barrier of asteroids, and materials ejected from the
secondary due to the DART impact are likely to reach the primary. These
conditions may cause the primary to reshape, due to landslides, or internal
deformation, changing the permanent gravity field. Here, we propose that if
shape deformation of the primary occurs, the mutual orbit of the system would
be perturbed due to a change in the gravity field. We use a numerical
simulation technique based on the full two-body problem to investigate the
shape effect on the mutual dynamics in Didymos after the DART impact. The
results show that under constant volume, shape deformation induces strong
perturbation in the mutual motion. We find that the deformation process always
causes the orbital period of the system to become shorter. If surface layers
with a thickness greater than ~0.4 m on the poles of the primary move down to
the equatorial region due to the DART impact, a change in the orbital period of
the system and in the spin period of the primary will be detected by
ground-based measurement.Comment: 8 pages, 7 figures, 2 tables, accepted for publication in MNRA
A low-temperature phase of bis(tetrabutylammonium) octa-l3-chloridohexachlorido- octahedro-hexatungstate
The article discusses the low-temperature phase of bis(tetrabutylammonium) octa-µ3-chlorido-hexachlorido-octahedro-hexa-tungstate, which undergoes a reversible phase transition at 268 K. The unit cells of the room- and low-temperature polymorphs of this compound are found to be closely related. The hydrocarbon chain of one of the tetrabutylammonium cations is found to be disordered at both 150 and 200 K
Seeing double with K2: Testing re-inflation with two remarkably similar planets around red giant branch stars
Despite more than 20 years since the discovery of the first gas giant planet
with an anomalously large radius, the mechanism for planet inflation remains
unknown. Here, we report the discovery of EPIC228754001.01, an inflated gas
giant planet found with the NASA K2 Mission, and a revised mass for another
inflated planet, K2-97b. These planets reside on ~9 day orbits around host
stars which recently evolved into red giants. We constrain the irradiation
history of these planets using models constrained by asteroseismology and
Keck/HIRES spectroscopy and radial velocity measurements. We measure planet
radii of 1.31 +\- 0.11 Rjup and and 1.30 +\- 0.07 Rjup, respectively. These
radii are typical for planets receiving the current irradiation, but not the
former, zero age main sequence irradiation of these planets. This suggests that
the current sizes of these planets are directly correlated to their current
irradiation. Our precise constraints of the masses and radii of the stars and
planets in these systems allow us to constrain the planetary heating efficiency
of both systems as 0.03% +0.03%/-0.02%. These results are consistent with a
planet re-inflation scenario, but suggest the efficiency of planet re-inflation
may be lower than previously theorized. Finally, we discuss the agreement
within 10% of stellar masses and radii, and planet masses, radii, and orbital
periods of both systems and speculate that this may be due to selection bias in
searching for planets around evolved stars.Comment: 18 pages, 15 figures, accepted to AJ. Figures 11, 12, and 13 are the
key figures of the pape
Prospective Evaluation of the Influence of Iterative Reconstruction on the Reproducibility of Coronary Calcium Quantification in Reduced Radiation Dose 320 Detector Row CT.
BACKGROUND: Coronary artery calcium (CAC) predicts coronary heart disease events and is important for individualized cardiac risk assessment. This report assesses the interscan variability of CT for coronary calcium quantification using image acquisition with standard and reduced radiation dose protocols and whether the use of reduced radiation dose acquisition with iterative reconstruction (IR; reduced-dose/IR ) allows for similar image quality and reproducibility when compared to standard radiation dose acquisition with filtered back projection (FBP; standard-dose/FBP ) on 320-detector row computed tomography (320-CT).
METHODS: 200 consecutive patients (60 ± 9 years, 59% male) prospectively underwent two standard- and two reduced-dose acquisitions (800 total scans, 1600 reconstructions) using 320 slice CT and 120 kV tube voltage. Automated tube current modulation was used and for reduced-dose scans, prescribed tube current was lowered by 70%. Image noise and Agatston scores were determined and compared.
RESULTS: Regarding stratification by Agatston score categories (0, 1-10, 11-100, 101-400, \u3e400), reduced-dose/IR versus standard-dose/FBP had excellent agreement at 89% (95% CI: 86-92%) with kappa 0.86 (95% CI: 0.81-0.90). Standard-dose/FBP rescan agreement was 93% (95% CI: 89-96%) with kappa = 0.91 (95% CI: 0.86-0.95) while reduced-dose/IR rescan agreement was similar at 91% (95% CI: 87-94%) with kappa 0.88 (95% CI: 0.83-0.93). Image noise was significantly higher but clinically acceptable for reduced-dose/IR (18 Hounsfield Unit [HU] mean) compared to standard-dose/FBP (16 HU; p \u3c 0.0001). Median radiation exposure was 74% lower for reduced- (0.37 mSv) versus standard-dose (1.4 mSv) acquisitions.
CONCLUSION: Rescan agreement was excellent for reduced-dose image acquisition with iterative reconstruction and standard-dose acquisition with filtered back projection for the quantification of coronary calcium by CT. These methods make it possible to reduce radiation exposure by 74%.
CLINICAL TRIAL REGISTRATION: URL: https://clinicaltrials.gov/ct2/show/NCT01621594.
UNIQUE IDENTIFIER: NCT01621594
The Association Between Persistent White-Matter Abnormalities and Repeat Injury After Sport-Related Concussion
Objective: A recent systematic review determined that the physiological effects of concussion may persist beyond clinical recovery. Preclinical models suggest that ongoing physiological effects are accompanied by increased cerebral vulnerability that is associated with risk for subsequent, more severe injury. This study examined the association between signal alterations on diffusion tensor imaging following clinical recovery of sport-related concussion in athletes with and without a subsequent second concussion. Methods: Average mean diffusivity (MD) was calculated in a region of interest (ROI) in which concussed athletes (n = 82) showed significantly elevated MD acutely after injury (<48 h), at an asymptomatic time point, 7 days post-return to play (RTP), and 6 months relative to controls (n = 69). The relationship between MD in the identified ROI and likelihood of sustaining a subsequent concussion over a 1-year period was examined with a binary logistic regression (re-injured, yes/no). Results: Eleven of 82 concussed athletes (13.4%) sustained a second concussion within 12 months of initial injury. Mean MD at 7 days post-RTP was significantly higher in those athletes who went on to sustain a repeat concussion within 1 year of initial injury than those who did not (p = 0.048; d = 0.75). In this underpowered sample, the relationship between MD at 7 days post-RTP and likelihood of sustaining a secondary injury approached significance [χ2 (1) = 4.17, p = 0.057; B = 0.03, SE = 0.017; OR = 1.03, CI = 0.99, 1.07]. Conclusions: These preliminary findings raise the hypothesis that persistent signal abnormalities in diffusion imaging metrics at RTP following concussion may be predictive of a repeat concussion. This may reflect a window of cerebral vulnerability or increased susceptibility following concussion, though understanding the clinical significance of these findings requires further study
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Angiopoietins in Diabetic Retinopathy: Current Understanding and Therapeutic Potential.
Diabetic retinopathy (DR) is the commonest cause of blindness in the working-age population of the developed world. The molecular pathophysiology of DR is complex, and a complete spatiotemporal model of the disease is still being elucidated. Recently, a role for angiopoietin (Ang) proteins in the pathophysiology of DR has been proposed by several research groups, and several aspects of Ang signalling are being explored as novel therapeutic strategies. Here, we review the role of the Ang proteins in two important forms of DR, diabetic macular oedema and proliferative diabetic retinopathy. The function of the Ang proteins in regulating blood vessel permeability and neovascularisation is discussed, and we also evaluate recent preclinical and clinical studies highlighting the potential benefits of modulating Ang signalling as a treatment for DR.MW and PYWM are funded by Medical Research Council (UK) grants. MW, PYWM and AO 386 receive support from The Novo Nordisk UK Research Foundation, the Cambridge Eye Trust and 387 the Jukes Glaucoma Research Fund. AO, PYWM and KRM also hold Fight for Sight (UK) awards. 388 PYWM is also supported by a Clinician Scientist Fellowship Award (G1002570), the Isaac Newton 389 Trust, the UK National Institute of Health Research (NIHR) as part of the Rare Diseases 390 Translational Research Collaboration, and the NIHR Biomedical Research Centre based at 391 Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology. Research in 392 the laboratory is supported by core funding from Wellcome and MRC to the Wellcome-MRC 393 Cambridge Stem Cell Institute.Peer Reviewe
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