Resolution of lupus-related left ventricular wall thickening and interstitial lung disease in a child with pulsed steroids and cyclophosphamide

Cardiopulmonary involvement is one of the important manifestations of systemic lupus erythematosus (SLE) that tends to be more common in adults than children with SLE. SLE-related cardiopulmonary affection ranges from subclinical to life threatening condition. Although increased left ventricular mass and interstitial lung disease have been reported in association with SLE, the reversibility of such conditions with treatment of SLE was not sufficiently reported. Herein, we describe a female adolescent with SLE and lupus nephritis class III who presented as well with moderate dyspnea, tachycardia in absence of heart failure and hypertension. She had also productive cough of whitish sputum, no fever and both sputum and blood cultures were negative. Her echocardiography revealed left ventricular wall hypertrophy with preserved systolic function, electrocardiogram showed sinus tachycardia. Her pulmonary function tests revealed mild restrictive pattern and high resolution computed tomography revealed veiling of both lungs with increased attenuation and interstitial nodules with bilateral mild pleural effusion. She received full dose prednisone and intravenous monthly cyclophosphamide in addition to intravenous pulsed methylprednislone. She gradually improved with complete resolution of her cardiopulmonary disease and significant reduction of her proteinuria. In conclusion, cardiopulmonary involvement in relation to SLE could be reversible with adequate treatment leaving

The Effect of Breathing Exercises and Sleep Hygiene Instructions on Insomnia and Pain in Patients with Burn Injuries

Background: Insomnia and pain are the most commonly reported problems after burn injuries. Poor sleeping and pain can be extremely distressing and debilitating, and actually interfere with recovery from a burn injury. Aim: This study was intended to evaluate the effect of breathing exercises and sleep hygiene instructions on insomnia and pain in patients with burn injuries. Methods: A quasi-experimental design was utilized. A convenience sample of 60 male and female adults who were admitted to the burn unit in one of the biggest teaching hospitals in Cairo were recruited and randomly allocated to a control and intervention group. One questionnaire and four scales were utilized to collect the data: (1) Background data sheet, (2) The Behavioral Relaxation Scale (BRS), (3) Self-rating relaxation scale, (4) Visual Analogue Scale for assessing pain and fatigue and (5) Insomnia Severity Index. The patients were followed for three days. Results: The intervention group achieved a significantly higher reduction in the mean pain intensity score (p = 0.037), decreased insomnia (p = 0.001) and increased relaxation level (p = 0.000) after the intervention compared to the control group. Fatigue was not significantly different between the two groups (p = 0.069). Conclusions and recommendations: breathing exercises and sleep hygiene instructions could reduce pain and insomnia in patients with burn injuries. Thus, breathing exercises and sleep hygiene instructions must be endorsed as a nursing role for patients with burn injuries in the early course of the disease, so that the patients experience the maximum benefit. Keywords: burn, sleep hygiene instructions, insomnia, breathing exercises, pai

Exploring the oil supply-demand shocks and stock market stabilities: Experience from OECD countries

This paper explores the interactive relationships between oil price shocks and the stockmarket in 11 OECD countries using traditional cointegrationtest and look at the rolling window Granger causality effects with various predictive power contents running between the variables. Taking into account both world oil production and world oil prices in order to supervise for oil supply and oil demand shocks, strong evidence of the sensitivity of stock market returns to the oil priceshock specifications is found in several sub-periods. As for rolling window causality tests, it is found that the impact of oil price shocks substantially differs along the different countries and that the results also differ among the various oil shock specifications.The overall finding suggests that oil supply shocks have a negative effect on stock market returns in the net oil importing OECD countries. Indeed, the stock market returns are negatively impacted by oil demand shocks in the oil importing OECD countries and positively impactedby the oil exporting OECD countries. Furthermore, these results will give a dimension for future undertaking studies with varying empirical findings

Effect of the Soil Spatial Variability on the Static and Dynamic Stability Analysis of a Lebanese Slope

The accidental topography and heterogeneous Lebanese geology in addition to the active seismicity have initiated the static and dynamic stability analysis of Lebanese slopes. In this paper, the stability of a sandy Lebanese slope situated at Mansourieh near Beirut is investigated using deterministic and probabilistic approaches. The characterization of the variability of the slope soil properties is done based on geological investigation, as well as geophysical (Resistivity and Ambient noise) and geotechnical tests performed on this slope. Three dimensional 3D static deterministic analyses is performed to determine the overall safety factor of the slope and to find the location of the critical failure surface. The deterministic model is based on numerical simulations using the finite difference code FLAC3D. Then, two-dimensional probabilistic analysis is carried out on the critical section obtained from the 3D model. In the probabilistic analysis, the soil properties are modeled using the random field theory. An efficient uncertainty propagation methodology based on the expansion optimal linear estimation EOLE method is used to discretize the random field. Concerning the dynamic analysis, it is implemented in order to determine the amplification at the top of slope, where the looseness of the soil there may amplify the earthquake acceleration. The results have shown a small safety factor as well as high amplification. The importance of using the probabilistic approach versus the deterministic one is also presented and discussed

Control of tomato early blight and wilt using aqueous extract of neem leaves

The effect of neem (Azadiracta indica) leaf extract against Alternaria solani and Fusarium oxysporum, the causal agents of early blight and wilt of tomato plants (Lycopersicon esculentum Mill.) respectively, was studied. Concentrations (5, 10 and 20%) of aqueous neem extract suppressed mycelial growth of both pathogenic fungi and the degree of suppression gradually increased with increasing concentration. A concentration of 20% aqueous neem leaf extract sprayed on tomato plants lowered the incidence of Alternaria early blight from 53.2 to 42.5% after two weeks and from 100 to 79.2% after 4 weeks. Spraying plus irrigation with the same extract lowered the severity of Alternaria early blight from 26.8 to 11.4% after 2 weeks and from 61.7 to 17.9% after 4 weeks (control ratio of 43.71% after 4 weeks). For F. oxysporum wilt, germination of tomato seeds was highest in pots containing the negative control (soil free of pathogen) and in pots irrigated with the aqueous neem extract. The lowest disease incidence (19.04%) was obtained in pots treated with the pathogen and irrigated with aqueous neem extract, where an 81% control of Fusarium wilt was achieved. Growth parameters of tomato (shoot and root length, number of leaves, fresh and dry weight of shoots and roots) were studied 4, 6 and 8 weeks after sowing in the presence of the pathogens. There was a significant gradual increase in growth parameters when the plants were sprayed and irrigated with aqueous neem extract with the greatest improvement recorded 8 weeks after sowing

Comparative Toxicity of Neem and Peppermint Oils Nano Formulations against Agrotis ipsilon (Hufn.) Larvae (Lepidoptera: Noctuidae)

Applications of nanotechnology in agriculture will result in the development of efficient and potential approaches towards the management of insect pests. The toxicity effects of four essential oils peppermint, thyme, camphor and sage oils were tested against the fourth instar larvae of Agrotis ipsilon to select the most effective essential oil to be converted to the nano form. According to the results obtained, peppermint oil was the most toxic compound, which has been used in the present investigation  compared  with neem oil. The toxicity of  bulk and nano- formulations of neem  and pepper mint oils were tested  against  2nd and 4th instar  larvae of A. ipsilon under laboratory conditions of 25±2 °C& 65 -70 % R.H.relative humidity The results show that the LC50 value (the concentration used which kill 50% of the tested individuals)of loaded neem or pepper mint were lower (0.62 and 36.47 ppm) compared with neem or pepper mint oil nano-emulsion and bulk neem for the second larval instar. The different formulations of neem are more potent than in case of peppermint oil, as LC50 and LC90 values were significantly lower.The same trend was found concerning the 4th larval instar. Age of treated larvae had a detrimental effect on the response to the compounds tested. It was noticed that the younger larvae were much more sensitive to the prepared compounds compared to the older ones. The least LC50 value for loaded neem nano-emulsion was 6.68 ppm compared with the highest value for  bulk neem oil (16.68 ppm ). Also,  LC90  values followed the same trend as in  case ofLC50.  Again, the toxicity of loaded peppermint oil had the most insecticidal activity as expressed by the lowest LC50 value (51.9 ppm) with more insecticidal effect than the bulk(125.43 ppm)  or nano-emulsion (85.43 ppm).  The present results indicated that these novel systems could be used in integrated pest management program for A. ipsilon control

Comparative Toxicity of Neem and Peppermint Oils Nano Formulations against Agrotis ipsilon (Hufn.) Larvae (Lepidoptera: Noctuidae)

Applications of nanotechnology in agriculture will result in the development of efficient and potential approaches towards the management of insect pests. The toxicity effects of four essential oils peppermint, thyme, camphor and sage oils were tested against the fourth instar larvae of Agrotis ipsilon to select the most effective essential oil to be converted to the nano form. According to the results obtained, peppermint oil was the most toxic compound, which has been used in the present investigation  compared  with neem oil. The toxicity of  bulk and nano- formulations of neem  and pepper mint oils were tested  against  2nd and 4th instar  larvae of A. ipsilon under laboratory conditions of 25±2 °C& 65 -70 % R.H.relative humidity The results show that the LC50 value (the concentration used which kill 50% of the tested individuals)of loaded neem or pepper mint were lower (0.62 and 36.47 ppm) compared with neem or pepper mint oil nano-emulsion and bulk neem for the second larval instar. The different formulations of neem are more potent than in case of peppermint oil, as LC50 and LC90 values were significantly lower.The same trend was found concerning the 4th larval instar. Age of treated larvae had a detrimental effect on the response to the compounds tested. It was noticed that the younger larvae were much more sensitive to the prepared compounds compared to the older ones. The least LC50 value for loaded neem nano-emulsion was 6.68 ppm compared with the highest value for  bulk neem oil (16.68 ppm ). Also,  LC90  values followed the same trend as in  case ofLC50.  Again, the toxicity of loaded peppermint oil had the most insecticidal activity as expressed by the lowest LC50 value (51.9 ppm) with more insecticidal effect than the bulk(125.43 ppm)  or nano-emulsion (85.43 ppm).  The present results indicated that these novel systems could be used in integrated pest management program for A. ipsilon control

Simultaneous versus Sequential Accelerated Corneal Collagen Cross-Linking and Wave Front Guided PRK for Treatment of Keratoconus: Objective and Subjective Evaluation

Aim. To compare objective and subjective outcome after simultaneous wave front guided (WFG) PRK and accelerated corneal cross-linking (CXL) in patients with progressive keratoconus versus sequential WFG PRK 6 months after CXL. Methods. 62 eyes with progressive keratoconus were divided into two groups; the first including 30 eyes underwent simultaneous WFG PRK with accelerated CXL. The second including 32 eyes underwent subsequent WFG PRK performed 6 months later after accelerated CXL. Visual, refractive, topographic, and aberrometric data were determined preoperatively and during 1-year follow-up period and the results compared in between the 2 studied groups. Results. All evaluated visual, refractive, and aberrometric parameters demonstrated highly significant improvement in both studied groups (all P<0.001). A significant improvement was observed in keratometric and Q values. The improvement in all parameters was stable till the end of follow-up. Likewise, no significant difference was determined in between the 2 groups in any of recorded parameters. Subjective data revealed similarly significant improvement in both groups. Conclusions. WFG PRK and accelerated CXL is an effective and safe option to improve the vision in mild to moderate keratoconus. In one-year follow-up, there is no statistically significant difference between the simultaneous and sequential procedure

PROTECTIVE EFFECT OF SOME CHELATING AGENTS AND ANTIOXIDANTS ON THE BIOHAZARDS PRODUCED FROM WATER POLLUTION BY HEAVY METALS IN WISTAR RATS: BIOLOGICAL, GENETIC AND HISTOPATHOLOGICAL STUDY

Background: Heavy metals that normally cause problems are mercury (HgCl2) and lead acetate (LA). Chelating and inhibitor agents are the target to treat and overcome metal toxicity. The current study has been carried out to evaluate the protective effects of N-acetyl cysteine (NAC) and meso 2,3 dimercaptosuccinic acid (DMSA) against HgCl2 and LA toxicity. Materials and Methods: Ninety male Wistar rats were divided into nine equal groups. The groups were administered NAC and/or DMSA in presence or absence of LA (LA; 0.2% in drinking water) or HgCl2 (2 mg/kg BW) for 2 consecutive months. Serum and organs were collected for biochemical, genetic and histopathological changes. Results: Biochemical results revealed that LA and HgCl2 significantly increased the levels of liver and kidney biomarkers. Administration of NAC and DMSA considerably improved these altered changes. LA and HgCl2 decreased serum levels of antioxidants and were ameliorated in NAC and DMSA administered rats. LA and HgCl2 administration upregulated expression of IL-1β and IL-8 that were normalized by NAC and DMSA. Kidneys of LA and HgCl2 groups showed intraluminal hyaline casts. Kidneys of DMSA-administrated rats showed mild hydropic degeneration of renal tubular epithelium in LA and HgCl2 groups. Kidneys of NAC administrated rats showed atrophy of capillary tufts. Kidneys of LA and HgCl2 administered rats which received DMSA and NAC showed normal glomerular structure. Liver histopathology showed sever changes that were ameliorated by NAC and DMSA. Conclusion: Taken together, usage of NAC and DMSA provide significant protection against LA and HgCl2-induced hepatotoxicity and nephrotoxicity in male Wistar rats