Androgen deprivation therapy and radiotherapy in intermediate-risk prostate cancer: A systematic review and meta-analysis

ObjectivesAndrogen deprivation therapy combined with radiotherapy for intermediate-risk prostate cancer is still a matter of debate. We conducted a meta-analysis to evaluate the necessity of androgen deprivation therapy combined with radiotherapy for intermediate-risk prostate cancer patients.MethodsA comprehensive literature search of articles was performed in PubMed, Embase, Cochrane library, Web of Science, Chinese National Knowledge Infrastructure, Chinese Biological Medicine, Wanfang, and VIP Databases published between February 1988 and April 2022. Studies comparing the survival of patients diagnosed with intermediate-risk prostate cancer who were treated with androgen deprivation therapy combined with radiotherapy or radiotherapy alone were included. Data were extracted and analyzed with the RevMan software (version 5.3) and the Stata software (version 17).ResultsSix randomized controlled trials and nine retrospective studies, including 6853 patients (2948 in androgen deprivation therapy combined with radiotherapy group and 3905 in radiotherapy alone group) were enrolled. Androgen deprivation therapy combined with radiotherapy did not provide an overall survival (HR 1.12, 95% CI 1.01-1.12, p=0.04) or biochemical recurrence-free survival (HR 1.23, 95% CI 1.09-1.39, P=0.001) advantage to intermediate-risk prostate cancer patients.ConclusionAndrogen deprivation therapy combined with radiotherapy did not show some advantages in terms of overall survival and biochemical recurrence-free survival and radiotherapy alone may be the effective therapy for intermediate-risk prostate cancer patients.Systematic review registrationhttps://inplasy.com/inplasy-2022-8-0095/, identifier 202280095

Динамические характеристики деформации алюминиевого сплава 7055/7A52 при высоких нагрузках с использованием разрезного стержня Гопкинсона

High strain rate impact tests of 7055/7A52 clad alloy are conducted by using of a SHPB at temperatures ranging from 250 ℃ to 400 ℃ and strain rate ranging from 1000 s–1 to 3000 s–1 to investigate dynamic deformation behavior of 7055/7A52 clad alloy. The experimental results show that flow stress is influenced by both strain rate and temperatures and more sensitive to the strain rate. Flow stress increases with the strain rate and decreases with the temperatures. Based on the experimental results, a JC model constitute equation is developed to describe the relationship of strain rate (e.), deformation temperature (T) and flow stress (s) and it can predict the flow stress under if the deformation parameters are given

Microwave-assisted Synthesis of Greigite Fe

Greigite (Fe3S4), which have ferromagnetic in inverse thiospinel (AB2S4), is widely researched to use an adsorbent and biomedical field because non-toxicity and abundant in nature. Iron-based materials are known to have a high theoretical capacity because of their multivalent state including redox pairs, but still suffer from collapse and aggregate during the charge/discharge process. Here, the synthesized Fe3S4 nanosheet structure materials wrapped with reduced graphene oxide (Fe3S4NSs@rGO) were used as an anode electrode material for sodium-ion batteries (SIBs). The nano-sheet structure facilitates ion diffusion through expanded surface area, and rGO can effectively improve electrochemical conductivity and structure stability. As-prepared Fe3S4NSs@rGO were used as a host material to insert Na-ion via a conversion process, and the stabilized structure maintains the high capacity and long cycle performance. Thus, the Fe3S4NSs@rGO deliver a reversible capacity of 950 mAh g−1 after 200 cycles at a current density of 1A g−1 and 524 mAh g−1 after 400 cycles at a current density of 2A g−1, which is much higher than reported materials

Динамические характеристики деформации алюминиевого сплава 7055/7A52 при высоких нагрузках с использованием разрезного стержня Гопкинсона

High strain rate impact tests of 7055/7A52 clad alloy are conducted by using of a SHPB at temperatures ranging from 250 ℃ to 400 ℃ and strain rate ranging from 1000 s–1 to 3000 s–1 to investigate dynamic deformation behavior of 7055/7A52 clad alloy. The experimental results show that flow stress is influenced by both strain rate and temperatures and more sensitive to the strain rate. Flow stress increases with the strain rate and decreases with the temperatures. Based on the experimental results, a JC model constitute equation is developed to describe the relationship of strain rate (e.), deformation temperature (T) and flow stress (s) and it can predict the flow stress under if the deformation parameters are given

Characteristics of Heavy Metal Dusts in the Copper Matte Smelting Process and Progress in Accerations Control Technology

As one of the core technologies for copper smelting, matte smelting produces high-temperature flue gas with high SO2 concentration during the smelting process, which carries a large amount of dusts containing Cu, Pb, Zn, As and other harmful heavy metals. In industry, with the change of temperature and atmosphere in different parts of the flue gas system, the properties of the flue gas will hange gradually, and it will be separated from the flue gas gradually under the action of gravity and static electric field. However, some dust adhesion at high temperatures to rise and waste heat boiler flue wall or on the heat exchange tube, forming solid accerations, result in the boiler in thermal efficiency is lower, the gas flow crossing section decreases and increasing the risk of a harmful dust pollution of heavy metals. Therefore, studying the characteristics of copper smelting and the bonding behavior, accerations development of control technology has become the focus of the industry. The paper intends to compare and analyze the dust and accerations substance physical characteristics in different stages of the flue gas treatment system in different copper smelting processes by sorting out existing research work, and conclude and analyze the laws of composition phase change and accerations substance formation mechanism. At the same time, the progress of accerations control technology in industry is compared and reviewed, and some suggestions are put forward

Survival and complications after neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy for locally advanced gastric cancer: a systematic review and meta-analysis

BackgroundThere is increasing evidence that neoadjuvant chemoradiotherapy is superior to neoadjuvant chemotherapy for patients with locally advanced gastric cancer. However, a number of studies have come to the opposite conclusion. Therefore, our meta-analysis is to evaluate the efficacy and safety of neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy in the treatment of locally advanced gastric cancer.MethodsWe searched Wanfang Database, China National Knowledge Network database, VIP database, China Biomedical Literature Database, PubMed, Embase and Cochrane Library. The searched terms included’Stomach Neoplasms’, ‘Neoadjuvant Therapy’ and ‘Chemoradiotherapy’. The retrieval time was from the establishment of the corresponding database to September 2022, and our meta-analysis was performed using RevMan (version 5.3) and Stata (version 17) software.ResultsA total of 17 literatures were included, which involved 7 randomized controlled trials and 10 retrospective studies, with a total of 6831 patients. The results of meta-analysis showed that compared with NACT group, the complete response rate(RR=1.95, 95%CI 1.39-2.73, p=0.0001), the partial response rate(RR=1.44, 95%CI 1.22-1.71, p=0.0001), the objective response rate(RR=1.37, 95%CI 1.27-1.54, p=0.00001), the pathologic complete response rate(RR=3.39, 95%CI 2.17-5.30, p=0.00001), the R0 resection rate(RR=1.18, 95%CI 1.09-1.29, p=0.0001) and 3-year overall survival rate(HR=0.89, 95%CI 0.82-0.96, p=0.002) of neoadjuvant chemoradiotherapy group were significantly improved. The results of subgroup analyses of gastric cancer subgroup and gastroesophageal junction cancer subgroup were consistent with the overall results. Meanwhile, the stable disease(RR=0.59, 95%CI:0.44-0.81, P=0.0010) of neoadjuvant chemoradiotherapy group was lower than that of neoadjuvant chemotherapy group, and there were no statistical significance in the progressive disease rate(RR=0.57, 95%CI:0.31-1.03, P=0.06), five-year overall survival rate(HR=1.03, 95%CI:0.99-1.07, P=0.839), postoperative complications and adverse reactions between the neoadjuvant chemoradiotherapy group and neoadjuvant chemotherapy group.ConclusionCompared with neoadjuvant chemotherapy, neoadjuvant chemoradiotherapy might bring more survival benefits without significantly increasing adverse reactions. neoadjuvant chemoradiotherapy may be a recommended treatment for patients with locally advanced gastric cancer.Systematic Review Registrationhttps://inplasy.com/inplasy-2022-12-0068/, identifier INPLASY202212068

Successful treatment with amoxicillin-clavulanic acid: cutaneous nocardiosis caused by Nocardia brasiliensis

Aim To emphasize the role of non-sulfonamides in the treatment of Nocardia infection and reduce the adverse reactions caused by sulfonamides. Methods We retrospectively analyzed a case of cutaneous nocardiosis in an immunocompetent individual. The colonies obtained by staining the pus in the lesion with antacid and culturing the agar plates were identified by flight mass spectrometry. The pathogenic identification showed Nocardia brasiliensis infection and the patient was treated with amoxicillin-clavulanic acid. Results After treatment with amoxicillin and clavulanic acid, the ulcer gradually peeled and crusted, leaving dark pigmentation. The patient has finally recovered. Conclusion: Sulfonamides are the first-line antibacterial agents for years in treatment of nocardiosis but are of great toxicity and side effects. This patient was successfully treated with amoxicillin-clavulanic acid and it provided a reference protocol for patients with sulfonamide-resistant Nocardia or sulfonamides intolerance

Lithium Titanate Epitaxial Coating on Spinel Lithium Manganese Oxide Surface for Improving the Performance of Lithium Storage Capability

Spinel lithium titanate (Li₄Ti₅O₁₂, LTO) is applied as an epitaxial coating layer on LiMn₂O₄ hollow microspheres (LMO) through solvothermal-assisted processing. The epitaxial interface between LTO and LMO can be clearly observed by high resolution transmission electron microscopy (HR-TEM) and high angle annular dark field scanning transmission electron microscopy (HAADF-STEM) with atomic resolution images. The epitaxial coating cathode (EC-LMO@LTO) exhibits an excellent cyclability, thermal and rate capability for LIBs cathode due to the complete, thin LTO coating layer with strong adhesion to the host material. In addition, the small structure mismatch and high Li⁺-ion mobility of LTO can be beneficial to forming an efficient tunnel for Li⁺-ion transfer at the interface. It is suggested that EC-LMO@LTO can be recognized as a promising cathode material in electric vehicles (EVs) and plug-in hybrid electric vehicles (HEVs)

Fast-assembling nitrogen injection device for hot work of pipeline in station

Considering that the operation time should be saved as much as possible during the hot work of pipeline in oil and gas station, the time required for nitrogen injection, pipe cutting, welding, NDT and other processes in the hot work of pipeline in station was compared, and it was found that there was much space for time optimization in the nitrogen injection process. For conventional nitrogen injection method, the removal and reassembly of valves, nitrogen injection flanges and other components always result in huge workload and occupy a large amount of hot work time. By referring to the assembling form of flange gasket and changing the internal structure and assembling mode of nitrogen injection device, a fast-assembling type nitrogen injection device for hot work of pipeline in station was developed. With this device, the workload of bolt removal and assembling can be reduced by at least 50% for nitrogen injection, and the time for nitrogen injection process can be saved. Field application shows that, the problems of the nitrogen injection device for the hot work of pipeline in the station, such as inconvenient assembling, time-consuming works and inability to further improve the hot work efficiency, can be effectively handled by using this device, and the device is suggested to be popularized and applied in the hot work construction of pipeline and equipment in the petrochemical industry