9 research outputs found
<i>Myotis</i> bats’ uAACs within melanin associated genes.
<p><i>Myotis</i> bats’ uAACs within melanin associated genes.</p
The summed PROVEAN variant score for top 20 ranked genes. The lower the more significant.
<p>The summed PROVEAN variant score for top 20 ranked genes. The lower the more significant.</p
Phylogenetic relationships and divergence times in bats and mammalian species.
<p>The estimated divergence time (million years ago; MYA) is given at the nodes, with the 95% confidence intervals in parentheses. The calibration times of <i>M</i>. <i>brandtii—H</i>. <i>sapiens</i> (97.5 MYA), and <i>M</i>. <i>brandtii—P</i>. <i>alecto</i> (62.6 MYA) were derived from the TimeTree database. Colored branches and circles represent bat groups (<i>blue</i>: insect-eating microbat, <i>red</i>: fruits-eating mega bat). <i>M</i>. <i>domestica</i>, used as an outgroup species, was excluded in this figure.</p
Demographic history of <i>Myotis</i> bats.
<p><i>T</i><sub>surf</sub>, atmospheric surface air temperature (T indicates temperature, surf indicates surface); RSL, relative sea level; 10 m.s.l.e., 10 m sea level equivalent; g, generation time (years); μ, mutation rate per base pair per year.</p
Sequencing and mapping statistics of <i>M</i>. <i>rufoniger</i> genome.
<p>Sequencing and mapping statistics of <i>M</i>. <i>rufoniger</i> genome.</p
NY-ESO-1 expression in DCIS: A new predictor of good prognosis
BACKGROUND: At present, it is difficult to predict which patients with ductal carcinoma-in-situ (DCIS) will subsequently develop frank invasive breast cancer (IDC). A recent survey by our group has shown that NY-ESO-1 and MAGEA are both expressed in DCIS. This study was aimed at determining whether expression of these antigens was related to the later development of IDC. RESULTS: 14 of 42 (33%) of patients developed invasive breast cancer during the follow up period. Only one of those DCIS cases that relapsed was positive for NYESO-1 at diagnosis. In contrast, DCIS samples of 15 of the 28 (54%) of those patients who remained disease-free expressed NY-ESO-1. (Permutation chi square p=0.0033). METHODS: We identified 42 patients with DCIS, and followed them up for more than 10 years. NY-ESO-1 and MAGEA were demonstrated by immunostaining as were CD8+ infiltrates on all sections together with the conventional markers, ER, PR, and HER2. CONCLUSIONS: Expression of NY-ESO-1 may predict those patients who will not subsequently develop invasive breast cancer and could therefore potentially be helpful in defining prognosis in patients with DCIS
Additional file 2: Figure S1. of Comparison of carnivore, omnivore, and herbivore mammalian genomes with a new leopard assembly
Species and sub-species identification for three leopard samples. Figure S2. Distribution of K-mer frequency in the error-corrected reads. Figure S3. GC content distributions. Figure S4. Composition of mammalian orthologous genes. Figure S5. Divergence time estimation of 18 mammals. Figure S6. Contraction of the amylase gene families (AMY1 and AMY2) in carnivores. Figure S7. Frame-shift mutations in Felidae GCKR genes. Figure S8. Felidae-specific amino acid changes in DNA repair system. Figure S9. Felidae-specific amino acid change in MEP1A protein. Figure S10. Felidae-specific amino acid change in ACE2 protein. Figure S11. Felidae-specific amino acid change in PRCP protein. (DOCX 2024 kb
Additional file 2: Figure S1. of Comparison of carnivore, omnivore, and herbivore mammalian genomes with a new leopard assembly
Species and sub-species identification for three leopard samples. Figure S2. Distribution of K-mer frequency in the error-corrected reads. Figure S3. GC content distributions. Figure S4. Composition of mammalian orthologous genes. Figure S5. Divergence time estimation of 18 mammals. Figure S6. Contraction of the amylase gene families (AMY1 and AMY2) in carnivores. Figure S7. Frame-shift mutations in Felidae GCKR genes. Figure S8. Felidae-specific amino acid changes in DNA repair system. Figure S9. Felidae-specific amino acid change in MEP1A protein. Figure S10. Felidae-specific amino acid change in ACE2 protein. Figure S11. Felidae-specific amino acid change in PRCP protein. (DOCX 2024 kb