3,954 research outputs found
The Paper Trail: An Arid Connection & A Book of a Thousand Plants
Following my Ph.D., I moved on to Nebraska, where as a beginning faculty member I was able to start a research program in ecology and continue to study what intrigued me most: plant competition and stress. It was during this time that I came across the paper by Peter Alpert (see his article below) and his colleagues on āInvasiveness, invasibility, and the role of environmental stress in preventing the spread of non-native plantsā (Perspectives in Plant Ecology, Evolution and Systematics 3:52ā66). It was an āahaā moment in reading about biological invasion research and the current consensus at that time regarding invasiveness and invasibility in plant species and communities. I had seen first-hand or at least I had thought about things like nonnatives remaining noninvasive for long periods, the relationship between plasticity and invasiveness, and the āunlike invaderā hypothesis, which were all touched on in the paper. Add to this the discussion on the topic of stress (e.g., drought) affecting invasibility and the conceptual diagrams showing hypothetical responses of native and nonnatives under minimum and maximum levels, and I was convinced that my ideas were similar to those of others. For the first time, I did not feel alone in my thinking. In a way, it was a newfound freedom that allowed me to ponder more deeply the effects of stress on invasive plants. Extreme drought is a type of stress or selection pressure imposed on plants and communities of plants that can reveal fitness and plasticity differences that if understood could have profound impacts on invasion and community assembly theory
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Release of cholesterol-rich particles from the macrophage plasma membrane during movement of filopodia and lamellipodia.
Cultured mouse peritoneal macrophages release large numbers of ~30-nm cholesterol-rich particles. Here, we show that those particles represent fragments of the plasma membrane that are pulled away and left behind during the projection and retraction of filopodia and lamellipodia. Consistent with this finding, the particles are enriched in proteins found in focal adhesions, which attach macrophages to the substrate. The release of particles is abolished by blocking cell movement (either by depolymerizing actin with latrunculin A or by inhibiting myosin II with blebbistatin). Confocal microscopy and NanoSIMS imaging studies revealed that the plasma membrane-derived particles are enriched in 'accessible cholesterol' (a mobile pool of cholesterol detectable with the modified cytolysin ALO-D4) but not in sphingolipid-sequestered cholesterol [a pool detectable with ostreolysin A (OlyA)]. The discovery that macrophages release cholesterol-rich particles during cellular locomotion is likely relevant to cholesterol efflux and could contribute to extracellular cholesterol deposition in atherosclerotic plaques
Error Compensation of Single-Qubit Gates in a Surface Electrode Ion Trap Using Composite Pulses
The fidelity of laser-driven quantum logic operations on trapped ion qubits
tend to be lower than microwave-driven logic operations due to the difficulty
of stabilizing the driving fields at the ion location. Through stabilization of
the driving optical fields and use of composite pulse sequences, we demonstrate
high fidelity single-qubit gates for the hyperfine qubit of a
ion trapped in a microfabricated surface electrode ion
trap. Gate error is characterized using a randomized benchmarking protocol, and
an average error per randomized Clifford group gate of is
measured. We also report experimental realization of palindromic pulse
sequences that scale efficiently in sequence length
Palmoplantar keratoderma along with neuromuscular and metabolic phenotypes in Slurp1-deficient mice.
Mutations in SLURP1 cause mal de Meleda, a rare palmoplantar keratoderma (PPK). SLURP1 is a secreted protein that is expressed highly in keratinocytes but has also been identified elsewhere (e.g., spinal cord neurons). Here, we examined Slurp1-deficient mice (Slurp1(-/-)) created by replacing exon 2 with Ī²-gal and neo cassettes. Slurp1(-/-) mice developed severe PPK characterized by increased keratinocyte proliferation, an accumulation of lipid droplets in the stratum corneum, and a water barrier defect. In addition, Slurp1(-/-) mice exhibited reduced adiposity, protection from obesity on a high-fat diet, low plasma lipid levels, and a neuromuscular abnormality (hind-limb clasping). Initially, it was unclear whether the metabolic and neuromuscular phenotypes were due to Slurp1 deficiency, because we found that the targeted Slurp1 mutation reduced the expression of several neighboring genes (e.g., Slurp2, Lypd2). We therefore created a new line of knockout mice (Slurp1X(-/-) mice) with a simple nonsense mutation in exon 2. The Slurp1X mutation did not reduce the expression of adjacent genes, but Slurp1X(-/-) mice exhibited all of the phenotypes observed in the original line of knockout mice. Thus, Slurp1 deficiency in mice elicits metabolic and neuromuscular abnormalities in addition to PPK
A conflict management tool for conservation agencies
1. Growing pressure on natural resources is leading to more conservation conflicts. Governments and their statutory agencies devote increasing financial and human resources to this subject, but tend to adopt reactive, ad hoc approaches to management.
2. We combined theory and empirical data about five conservation conflicts in a transdisciplinary collaboration to co-develop a novel decision-making tool.
3. This tool uses a systematic stepwise approach with six distinct decision stages: (i) establishing whether there is a conflict or an impact; (ii) understanding the context of the conflict, including the stakeholders affected; (iii) developing shared understanding of the conflict and goals; (iv) building a consensus on how to reach the goals; (v) implementing measures; and (vi) monitoring the outcomes.
4. Policy implications. We argue this new tool has wide applicability and democratic legitimacy and offers an exciting and practical approach to improve the management of conservation conflicts
Spectra and Light Curves of Failed Supernovae
Astronomers have proposed a number of mechanisms to produce supernova
explosions. Although many of these mechanisms are now not considered primary
engines behind supernovae, they do produce transients that will be observed by
upcoming ground-based surveys and NASA satellites. Here we present the first
radiation-hydrodynamics calculations of the spectra and light curves from three
of these "failed" supernovae: supernovae with considerable fallback, accretion
induced collapse of white dwarfs, and energetic helium flashes (also known as
type .Ia supernovae).Comment: 33 pages, 14 figure
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