Systematic uncertainties in the precise determination of the strangeness magnetic moment of the nucleon

Systematic uncertainties in the recent precise determination of the strangeness magnetic moment of the nucleon are identified and quantified. In summary, G_M^s = -0.046 \pm 0.019 \mu_N.Comment: Invited presentation at PAVI '04, International Workshop on Parity Violation and Hadronic Structure, Laboratoire de Physique Subatomique et de Cosmologie, Grenoble, France, June 8-11, 2004. 7 pages, 16 figure

Arbuscular mycorrhizal community composition associated with two plant species in a grassland ecosystem

Arbuscular mycorrhizal (AM) fungi are biotrophic symbionts colonizing about two-thirds of land plant species and found in all ecosystems. They are of major importance in plant nutrient supply and their diversity is suggested to be an important determinant of plant community composition. The diversity of the AM fungal community composition in the roots of two plant species (Agrostis capillaris and Trifolium repens) that co-occurred in the same grassland ecosystem was characterized using molecular techniques. We analysed the small subunit (SSU) ribosomal RNA gene amplified from a total root DNA extract using AM fungal-specific primers. A total of 2001 cloned fragments from 47 root samples obtained on four dates were analysed by restriction fragment length polymorphism, and 121 of them were sequenced. The diversity found was high: a total of 24 different phylotypes (groups of phylogenetically related sequences) colonized the roots of the two host species. Phylogenetic analyses demonstrate that 19 of these phylotypes belonged to the Glomaceae, three to the Acaulosporaceae and two to the Gigasporaceae. Our study reveals clearly that the AM fungal community colonizing T. repens differed from that colonizing A. capillaris, providing evidence for AM fungal host preference. In addition, our results reveal dynamic changes in the AM fungal community through time

Correlators of supersymmetric Wilson-loops, protected operators and matrix models in N=4 SYM

We study the correlators of a recently discovered family of BPS Wilson loops in ${\cal N}=4$ supersymmetric U(N) Yang-Mills theory. When the contours lie on a two-sphere in the space-time, we propose a closed expression that is valid for all values of the coupling constant $g$ and for any rank $N$, by exploiting the suspected relation with two-dimensional gauge theories. We check this formula perturbatively at order ${\cal O}(g^4)$ for two latitude Wilson loops and we show that, in the limit where one of the loops shrinks to a point, logarithmic corrections in the shrinking radius are absent at ${\cal O}(g^6)$. This last result strongly supports the validity of our general expression and suggests the existence of a peculiar protected local operator arising in the OPE of the Wilson loop. At strong coupling we compare our result to the string dual of the ${\cal N}=4$ SYM correlator in the limit of large separation, presenting some preliminary evidence for the agreement.Comment: 20 page, 8 figure

Signatures of non-gaussianity in the isocurvature modes of primordial black hole dark matter

Primordial black holes (PBHs) are black holes which may have formed very early on during the radiation dominated era in the early universe. We present here a method by which the large scale perturbations in the density of primordial black holes may be used to place tight constraints on non-gaussianity if PBHs account for dark matter (DM). The presence of local-type non-gaussianity is known to have a significant effect on the abundance of primordial black holes, and modal coupling from the observed CMB scale modes can significantly alter the number density of PBHs that form within different regions of the universe, which appear as DM isocurvature modes. Using the recent \emph{Planck} constraints on isocurvature perturbations, we show that PBHs are excluded as DM candidates for even very small local-type non-gaussianity, $|f_{NL}|\approx0.001$ and remarkably the constraint on $g_{NL}$ is almost as strong. Even small non-gaussianity is excluded if DM is composed of PBHs. If local non-Gaussianity is ever detected on CMB scales, the constraints on the fraction of the universe collapsing into PBHs (which are massive enough to have not yet evaporated) will become much tighter.Comment: 23 pages, 11 figures. V2: minor corrections and changes, matches published versio

Mechanical Regulation of Wnt/β-catenin Signaling in Bone Cells

poster abstractThe Wnt/β-catenin signaling pathway is an important regulatory pathway in development and maintenance of various tissues, including bone. Active Wnt interacts with the frizzled/LRP receptor activating dishevelled, which in turn inactivates the GSK-3β complex and allows βcatenin to accumulate in the cytoplasm. β-catenin translocates to the nucleus where it activates a wide number of developmental target genes. Wnt can be sequestered by soluble frizzled related protein causing the inactivation of dishevelled, allowing for activation of the GSK-3β complex. This activated complex binds β-catenin and targets it for degradation. In addition to its other major role as a linker between cadherins and the actin cytoskeleton, β-catenin accumulation in the cytoplasm and subsequent translocation to the nucleus is a key step in the wnt/β-catenin signaling pathway. In bone, wnt/β-catenin signaling regulates skeletal formation, limb development and osteoblast maturation. Both active and inactive wnt/β-catenin signaling regulate bone cell development, active wnt/β-catenin signaling promotes osteoblast formation, while inactive wnt/β-catenin signaling inhibits osteoclast differentiation. Mechanical regulation of bone cells occurs through a process known as mechanotransduction which can be induced by fluid shear stress that occurs across the surfaces of osteoblasts and osteocytes, the effector cells of mechanotransduction. We hypothesize that knocking down β-catenin expression in mouse osteoblasts and osteoprogenitors will change the way these cells respond to fluid shear stress and regulate expression of relevant bone target genes. The future aims of this project are to assess the role of β-catenin during fluid shear stress induced osteoprogenitor cell differentiation by examining the expression of important osteoblast differentiation markers including: runx2, COX2, osteopontin, and osteocalcin and evaluate the significance of β-catenin during differentiation of bone marrow stromal cells

A Model to Estimate Sediment Yield from Field-Sized Areas: Development of Model

A tool for evaluating sediment yield from field-sized areas is needed for planning management practices to control sediment yield. We developed a reasonably simple simulation model which incorporates fundamental principles of erosion, deposition, and sediment transport mechanics. The model summarizes the state-of-the-art in erosion and sediment yield modeling with appropriate simplifications required to couple the governing equations. Limited testing showed that the procedures developed here give improved estimates over the Universal Soil Loss Equation. Specific components of the model were tested using experimental data from overland flow, erodible channel, and impoundment studies. These results suggest that the model produces reasonable estimates of erosion, sediment transport, and deposition under a variety of circumstances common to field-scale areas. Alternative management practices such as conservation tillage, terracing, and contouring can be evaluated separately or in combination to determine their influence on sediment yield. Given a particular location with specified characteristics for climate, soils, topography, and crops, the model provides a means of evaluating alternative management practices to suit a particular farming operation

Use of geostatistical Bayesian updating to integrate airborne radiometrics and soil geochemistry to improve mapping for mineral exploration

Mineral exploration programmes around the world use data from remote sensing, geophysics, and direct sampling. On a regional scale, the combination of airborne geophysics and ground-based geochemical sampling can aid geological mapping and mineral exploration. Since airborne geophysical and traditional soil-sampling data are generated at different spatial resolutions, they are not immediately comparable due to their different sampling density. Several geostatistical techniques, including indicator cokriging and collocated cokriging, can be used to integrate different types of data into a geostatistical model. However, with increasing numbers of variables the inference of the crosscovariance model required for cokriging can be demanding in terms of effort and computational time. In this paper a Gaussian-based Bayesian updating approach is applied to integrate airborne radiometric data and ground-sampled geochemical soil data to maximize information generated from the soil survey, enabling more accurate geological interpretation for the exploration and development of natural resources. The Bayesian updating technique decomposes the collocated estimate into two models: prior and likelihood models. The prior model is built from primary information and the likelihood model is built from secondary information. The prior model is then updated with the likelihood model to build the final model. The approach allows multiple secondary variables to be simultaneously integrated into the mapping of the primary variable. The Bayesian updating approach is demonstrated using a case study from Northern Ireland. The geostatistical technique was used to improve the resolution of soil geochemistry, at a density of one sample per 2 km2, by integrating more closely measured airborne geophysical data from the GSNI Tellus Survey, measured over a footprint of 65 x 200 m. The directly measured geochemistry data were considered as primary data and the airborne radiometric data were used as secondary data. The approach produced more detailed updated maps and in particular enhanced information on the mapped distributions of zinc, copper, and lead. The enhanced delineation of an elongated northwest/southeast trending zone in the updated maps strengthened the potential for discovering stratabound base metal deposits

Continuous Melting of a "Partially Pinned" Two-Dimensional Vortex Lattice in a Square Array of Pinning Centers

The structure and equilibrium properties of a two-dimensional system of superconducting vortices in a periodic pinning potential with square symmetry are studied numerically. For a range of the strength of the pinning potential, the low-temperature crystalline state exhibits only one of the two basic periodicities (in the $x$- and $y$-directions) of the pinning potential. This ``partially pinned'' solid undergoes a continuous melting transition to a weakly modulated liquid as the temperature is increased. A spin model, constructed using symmetry arguments, is shown to reproduce the critical behavior at this transition.Comment: 5 pages, 4 figure

Building capacity for development and implementation of clinical practice guidelines

Robust, reliable and transparent methodologies are necessary to ensure that clinical practice guidelines (CPGs) meet international criteria. In South Africa (SA) and other low- and middle-income countries, upskilling and training of individuals in the processes of CPG development is needed. Since de novo CPG development is time-consuming and expensive, new emerging CPG-development approaches (adopting, contextualising, adapting and updating existing good-quality CPGs) are potentially more appropriate for our context. These emerging CPG-development methods are either not included or sparsely covered in existing training opportunities. The SA Guidelines Excellence (SAGE) team has responded innovatively to the need for CPG training in SA. We have revised an existing SA course and developed an online, open-access CPG-development toolkit. This Guideline Toolkit is a comprehensive guideline resource designed to assist individuals who are interested in knowing how to develop CPGs. Findings from the SAGE project can now be implemented with this innovative CPG training programme. This level of CPG capacity development has the potential to influence CPG knowledge, development, practices and uptake by clinicians, managers, academics and policy-makers around the country