Association between triglyceride glucose index and breast cancer in 142,184 Chinese adults: findings from the REACTION study

BackgroundThe triglyceride glucose (TyG) index has been associated with an increased risk in breast cancer. However, this association remains unclear among the Chinese population. This study aimed to investigate whether the TyG index is associated with the risk of prevalent breast cancer in Chinese women.MethodsThis cross-sectional study included 142,184 women from the REACTION (Risk Evaluation of Cancers in Chinese Diabetic Individuals: A Longitudinal) Study, which recruited adults aged 40 years or older from 25 centers across mainland China between 2011 and 2012. The TyG index was calculated according to the formula: Ln (fasting triglycerides [mg/dL] × fasting glucose [mg/dL]/2). Multivariable-adjusted logistic regression models were used to evaluate odds ratios (ORs) and 95% confidence intervals (CIs) regarding the associations between the TyG index and breast cancer.ResultsMultivariable-adjusted logistic regression analysis showed that compared with the lowest quartile of the TyG index, the highest quartile of the TyG index was significantly associated with an increased risk of prevalent breast cancer, with an OR (95% CI) of 1.61 (1.19–2.17). In the stratified analysis, the association of each 1 SD increase in the TyG index with risk of prevalent breast cancer was more dominant in individuals with menarche at age 13–17, those who were postmenopausal, those with a history of breastfeeding, and those who had two to four children, with the ORs (95% CIs) of 1.35 (1.09–1.68), 1.27 (1.05–1.54), 1.26 (1.05–1.52), and 1.32 (1.08–1.62), respectively. Moreover, among those without discernible insulin resistance (homeostatic model assessment-insulin resistance [HOMA-IR] ≥2.5), hyperglycemia and dyslipidemia, each 1 SD increase in the TyG index was associated with a 1.36-fold increase in breast cancer risk, with an OR (95% CI) of 2.36 (1.44–3.87).ConclusionThe TyG index is significantly associated with the prevalent breast cancer risk among middle-aged and elderly Chinese women

Recurrent Filmwise and Dropwise Condensation on a Beetle Mimetic Surface

Vapor condensation plays a key role in a wide range of industrial applications including power generation, thermal management, water harvesting and desalination. Fast droplet nucleation and efficient droplet departure as well as low interfacial thermal resistance are important factors that determine the thermal performances of condensation; however, these properties have conflicting requirements on the structural roughness and surface chemistry of the condensing surface or condensation modes (<i>e.g.</i>, filmwise <i>vs</i> dropwise). Despite intensive efforts over the past few decades, almost all studies have focused on the dropwise condensation enabled by superhydrophobic surfaces. In this work, we report the development of a bioinspired hybrid surface with high wetting contrast that allows for seamless integration of filmwise and dropwise condensation modes. We show that the synergistic cooperation in the observed recurrent condensation modes leads to improvements in all aspects of heat transfer properties including droplet nucleation density, growth rate, and self-removal, as well as overall heat transfer coefficient. Moreover, we propose an analytical model to optimize the surface morphological features for dramatic heat transfer enhancement

Inhibition of condensation-induced droplet wetting by nano-hierarchical surfaces

Superhydrophobic nanostructured surfaces can enhance water condensation efficiency by facilitating droplet departure via coalescence-induced jumping. However, condensed droplets tend to transit from a mobile jumping mode to a highly pinned state at high condensation heat flux because excessive water nucleates within the nanostructures and anchors the condensed droplets. The large pinned droplets act as a thermal barrier and insulate the cooling surface, thus severely degrading its heat transfer efficiency. This work developed a nanohierarchical structured surface by growing branched TiO₂ nanorod arrays to prevent condensation-induced droplet pinning. After hydrophobization, the nano-hierarchical structure can spontaneously push the water out of nanostructures with an outward Laplace capillary pressure gradient when the droplet size is only at the nanoscale level. This effective de-wetting process maintains the high droplet mobility on the nano-hierarchical surface over a wide subcooling range, resulting in an up to ~ 90 % increase in heat transfer coefficient at a high heat flux of 132 kW•m⁻² compared to the single-tier nanorod surface. Our investigation of how the nanohierarchical structures fundamentally suppress the condensation-induced wetting on superhydrophobic surfaces represents a significant advance in understanding multiphase wetting phenomena and paves the way for the rational design of cooling surfaces.ISSN:0300-9467ISSN:1385-8947ISSN:1873-3212ISSN:0923-046

Controllable Formation of Monodisperse Polymer Microbubbles as Ultrasound Contrast Agents

Microbubbles have been widely used as ultrasound contrast agents in clinical diagnosis and hold great potential for ultrasound-mediated therapy. However, polydispersed population and short half-life time (<10 min) of the microbubbles still limit their applications in imaging and therapy. To tackle these problems, we develop a microfluidic flow-focusing approach to produce monodisperse microbubbles stabilized by Poly­(lactic-co-glycolic acid) (PLGA) as the polymer shell. The size of PLGA microbubbles can be tightly controlled from ∼600 nm to ∼7 μm with a coefficient of variation less than 4% in size distribution for ensuring highly homogeneous echogenic behavior of PLGA polymer microbubbles in ultrasound fields. Both in vitro and in vivo experiments showed that the monodisperse PLGA microbubbles had excellent echogenicity and elongated sonographic duration time (>3 times) for ultrasound imaging in comparison with the commercial lipid microbubbles