Stress oxydant et infarctus du Myocarde

Myocardial infarction is the leading cause of death in developed nations despite of recent advances in the management of this disease. Oxidative stress is involved in the physiopathology of Myocardial Infarction. Our study showed a decreased antioxidant activities in patients with Acute Myocardial Infarction. A part of the present study was designed to explore Peroxiredoxin Thioredoxin activity. It’s considered as a major antioxidant system and it control hydrogen peroxide levels which mediate the signal transduction, including apoptosis signal. Molecular mechanisms underlying the oxidative stress toxicity in cardiomyocytes have to be more elucidated and may help the evolving of therapeutic care strategies of coronary heart disease.L’infarctus du myocarde est l’une des principales causes de morbi-mortalité dans les pays développés, malgré l’amélioration enregistrée dans la prise en charge thérapeutique de cette urgence coronaire. Le stress oxydant est un facteur impliqué dans la physiopathologie de l’IDM. Notre étude a montré la diminution des capacités antioxydantes chez des patients hospitalisés pour un IDM aigu. Une partie de notre étude a été consacrée pour explorer le système Peroxyredoxine Thioredoxine. Il s’agit d’un système antioxydant majeur impliqué dans la régulation des voies d’apoptose. La connaissance des mécanismes moléculaires responsables des lésions myocardiques lors d’une ischémie, constitue l’une des avancées importantes dans la compréhension de la physiopathologie des syndromes coronaires aigus

Oxidative stress and myocardial infarction

L’infarctus du myocarde est l’une des principales causes de morbi-mortalité dans les pays développés, malgré l’amélioration enregistrée dans la prise en charge thérapeutique de cette urgence coronaire. Le stress oxydant est un facteur impliqué dans la physiopathologie de l’IDM. Notre étude a montré la diminution des capacités antioxydantes chez des patients hospitalisés pour un IDM aigu. Une partie de notre étude a été consacrée pour explorer le système Peroxyredoxine Thioredoxine. Il s’agit d’un système antioxydant majeur impliqué dans la régulation des voies d’apoptose. La connaissance des mécanismes moléculaires responsables des lésions myocardiques lors d’une ischémie, constitue l’une des avancées importantes dans la compréhension de la physiopathologie des syndromes coronaires aigus.Myocardial infarction is the leading cause of death in developed nations despite of recent advances in the management of this disease. Oxidative stress is involved in the physiopathology of Myocardial Infarction. Our study showed a decreased antioxidant activities in patients with Acute Myocardial Infarction. A part of the present study was designed to explore Peroxiredoxin Thioredoxin activity. It’s considered as a major antioxidant system and it control hydrogen peroxide levels which mediate the signal transduction, including apoptosis signal. Molecular mechanisms underlying the oxidative stress toxicity in cardiomyocytes have to be more elucidated and may help the evolving of therapeutic care strategies of coronary heart disease

Metabolic interactions between hyperhomocysteinemia and endothelin-1 among Tunisian patients with acute coronary diseases

BACKGROUND: Acute coronary syndromes (ACS) are complex and polygenic diseases which are a real problem of public health. These syndromes require multidisciplinary studies to understand the pathogenesis mechanisms and metabolic interactions between different risk factors.This study aimed to explore the variation of two coronary risk parameters not mentioned by Framingham cohorts, hyperhomocysteinemia and endothelin-1 (ET-1) in Tunisian coronary and the study of the variation of these parameters based on various cardiac risk factors and metabolic relationship between them.To 157 coronary and 142 healthy subjects, the concentration of homocysteine was quantified by fluorescence polarization immunoassay; the concentration of ET-1 was measured by an analytical technique, the High Performance Liquid Chromatography (HPLC) coupled with mass spectrometry. RESULTS: Our study showed that homocysteine and ET-1 were significantly higher in patients compared to healthy subjects (24.40 ± 12.5 μmol/L vs 7.44 ± 2.5 μmol/L p <0.00001) for homocysteine and (15.2 ± 5.3 nmol/L vs 7.1 ± 2.7 nmol/L, p <0.00001) for ET-1. On the other hand, homocysteine varies according to tobacco and diabetes while ET-1 depends on the sex, hypertension, smoking, obesity and dyslipidemia and a statistically negative correlation was shown between homocysteine and ET-1 in coronary patients (r = -0.66 p <0.00001. CONCLUSION: The study of the variation of these two parameters in coronary patients and metabolic exploration of the relationship between homocysteine and ET-1 according to various risk factors and the interactions between themselves facilitates the decision of therapeutic treatment