102 research outputs found
Metal-to-insulator transition in anatase TiO2 thin films induced by growth rate modulation
We demonstrate control of the carrier density of single phase anatase TiO2
thin films by nearly two orders of magnitude by modulating the growth kinetics
during pulsed laser deposition, under fixed thermodynamic conditions. The
resistivity and the intensity of the photoluminescence spectra of these TiO2
samples, both of which correlate with the number of oxygen vacancies, are shown
to depend strongly on the growth rate. A quantitative model is used to explain
the carrier density changes.Comment: 13 pages 3 figure
Gain in a quantum wire laser of high uniformity
A multi-quantum wire laser operating in the 1-D ground state has been
achieved in a very high uniformity structure that shows free exciton emission
with unprecedented narrow width and low lasing threshold. Under optical pumping
the spontaneous emission evolves from a sharp free exciton peak to a
red-shifted broad band. The lasing photon energy occurs about 5 meV below the
free exciton. The observed shift excludes free excitons in lasing and our
results show that Coulomb interactions in the 1-D electron-hole system shift
the spontaneous emission and play significant roles in laser gain.Comment: 4 pages, 4 figures, prepared by RevTe
The X-ray CCD camera of the MAXI Experiment on the ISS/JEM
MAXI, Monitor of All-sky X-ray Image, is the X-ray observatory on the
Japanese experimental module (JEM) Exposed Facility (EF) on the International
Space Station (ISS). MAXI is a slit scanning camera which consists of two kinds
of X-ray detectors: one is a one-dimensional position-sensitive proportional
counter with a total area of , the Gas Slit Camera (GSC), and
the other is an X-ray CCD array with a total area , the
Solid-state Slit Camera (SSC). The GSC subtends a field of view with an angular
dimension of 1 while the SSC subtends a field of view
with an angular dimension of 1 times a little less than 180. In
the course of one station orbit, MAXI can scan almost the entire sky with a
precision of 1 and with an X-ray energy range of 0.5-30 keV. We have
developed the engineering model of CCD chips and the analogue electronics for
the SSC. The energy resolution of EM CCD for Mn K has a full-width at
half maximum of 182 eV. Readout noise is 11 e^- rms.Comment: 10 pages, 4 figures Accepted for Nuclear Instruments and Method in
Physics Researc
Enhanced abundances in three large-diameter mixed-morphology supernova remnants
We present an X-ray study of three mixed-morphology supernova remnants
(SNRs), HB 21, CTB 1 and HB 3, using archival ASCA and ROSAT data. These data
are complemented by archival Chandra X-ray Observatory data for CTB 1 and
XMM-Newton X-ray Observatory data for HB 3. The spectra from HB 21 and HB 3 are
well-described with a single-temperature thermal plasma in ionization
equilibrium, while a two-temperature thermal plasma is found in CTB 1. We found
enhanced abundances in all three SNRs. The elemental abundance of Mg is clearly
enhanced in CTB 1, while HB 21 has enhanced abundances of Si and S. The
situation is not so clear in HB 3 -- the plasma in this SNR either has
significantly enhanced abundances of O, Ne and Mg, or it has marginally
enhanced abundances of Mg and under-abundant Fe. We discuss the plausibility of
mixed-morphology SNR models for the three SNRs and the presence of enhanced
abundances. We revise a list of MM SNRs and their properties, compare the three
SNRs studied here with other members of this class, and discuss the presence of
enhanced elemental abundances in MM SNRs. We also report the ASCA detection of
a compact source in the southern part of HB 3. The source spectrum is
consistent with a power law with a photon index of ~2.7, and an unabsorbed
X-ray flux of ~10^{-12} erg/cm^2/s in the 0.5--10.0 keV band. The column
density towards this source differs from that towards the SNR, and it is
therefore unlikely they are related.Comment: 26 pages, 15 figures, revised version (minor changes), accepted for
publication in ApJ (10 Aug 2006
Conceptualisation, Development, Fabrication and In Vivo Validation of a Novel Disintegration Tester for Orally Disintegrating Tablets
Disintegration time is the key critical quality attribute for a tablet classed as an Orally Disintegrating Tablet (ODT). The currently accepted in vitro testing regimen for ODTs is the standard United States Pharmacopeia (USP) test for disintegration of immediate release tablets, which requires a large volume along with repeated submergence of the dosage form within the disintegration medium. The aim of this study was to develop an in vivo relevant ODT disintegration test that mimicked the environment of the oral cavity, including lower volume of disintegration medium, with relevant temperature and humidity that represent the conditions of the mouth. The results showed that the newly developed Aston test was able to differentiate between different ODTs with small disintegration time windows, as well as between immediate release tablets and ODTs. The Aston test provided higher correlations between ODT properties and disintegration time compared to the USP test method and most significantly, resulted in a linear in vitro/in vivo correlation (IVIVC) (R 2 value of 0.98) compared with a "hockey stick" profile of the USP test. This study therefore concluded that the newly developed Aston test is an accurate, repeatable, relevant and robust test method for assessing ODT disintegration time which will provide the pharmaceutical industry and regulatory authorities across the world with a pragmatic ODT testing regime
J-shaped relationship between waist circumference and subsequent risk for Type 2 diabetes: An 8-year follow-up of relatively lean Japanese individuals
金沢大学医薬保健研究域医学系金沢医科大学健康増進予防医学(公衆衛生学)Aims This study investigated the relationship between waist circumference and the subsequent incidence of Type 2 diabetes and the association with insulin resistance and pancreatic B-cell function in relatively lean Japanese individuals. Methods The study participants were 3992 employees (2533 men and 1459 women, aged 35-55 years) of a metal-products factory in Japan. The incidence of diabetes was determined in annual medical examinations during an 8-year follow-up. We calculated age- and sex-adjusted hazard ratios (HRs) according to the sex-specific quintile of waist circumference at baseline. Differences in baseline insulin resistance [homeostatis model assessment (HOMA)-IR] and pancreatic B-cell function (HOMA-B) were compared between participants who developed diabetes and those who did not. Results During the follow-up, 218 participants developed diabetes. Age- and sex-adjusted HRs across the quintiles of waist circumference were 1.78, 1.00 (reference), 1.59, 3.11 and 3.30, respectively (P for trend, < 0.0001). The HR for the lowest quintile was significantly higher than that for the second quintile. Among participants with waist circumference of the lowest quintile, HOMA-B was lower in those who developed diabetes than in those who did not [33.1 (24.1-45.0) vs. 54.3 (37.9-74.6) median (interquartile range), P < 0.0001], but HOMA-IR did not differ between these groups. Conclusions There was a J-shaped relationship between waist circumference and subsequent risk for Type 2 diabetes in relatively lean Japanese individuals; lower pancreatic B-cell function may also increase the risk of diabetes in very lean Japanese people. © 2009 Diabetes UK
Investigation of the urinary sodium-to-potassium ratio target level based on the recommended dietary intake goals for the Japanese population: The INTERMAP Japan
Growing epidemiological evidence has shown an association of the urinary sodium (Na) to potassium (K) ratio (Na/K ratio) with blood pressure and cardiovascular diseases. However, no clear cutoff level has been defined. We investigated the cutoff level of the urinary Na/K ratio under different dietary guidelines for Japanese individuals, especially that endorsed by the 2020 revised Japanese Dietary Reference Intakes (DRIs). A population of 1145 Japanese men and women aged 40 to 59 years from the INTERMAP study was examined. Using high-quality standardized data, the averages of two 24 h urinary collections and four 24 h dietary recalls were used to calculate the 24 h urinary and dietary Na/K ratios, respectively. Associations between the urinary and dietary Na/K ratios were tested by sex- and age-adjusted partial correlation. The optimal urinary Na/K ratio cutoff level was determined by receiver operating characteristic (ROC) curves and sex-specific cross tables for recommended dietary K and salt. Overall, the average molar ratio of 24 h urinary Na/K was 4.3. We found moderate correlations (P < 0.001) of the 24 h urinary Na/K ratio with 24 h urinary Na and K excretion (r = 0.52, r = −0.49, respectively) and the dietary Na/K ratio (r = 0.53). ROC curves showed that a 24 h urinary Na/K ratio of approximately 2 predicted Na and K intake that meets the dietary goals of the Japanese DRIs. The range of urinary Na/K ratios meeting the dietary goals of the Japanese DRIs for both Na and K was 1.6‒2.2 for men and 1.7‒1.9 for women. Accomplishing a urinary Na/K ratio of 2 would be desirable to achieve the DRIs dietary goals for both Na and K simultaneously in middle-aged Japanese men and women accustomed to Japanese dietary habits. This observational study is registered at www.clinicaltrials.gov as NCT00005271
The cingulate island sign within early Alzheimer’s disease-specific hypoperfusion volumes of interest is useful for differentiating Alzheimer’s disease from dementia with Lewy bodies
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