ショウチョウジョウヒオケイユスルメンエキグロブリンノトランスロケーションニカンスルケンキュウ

京都大学0048新制・論文博士医学博士乙第3696号論医博第762号新制||医||250(附属図書館)5680UT51-53-M125(主査)教授 花岡 正男, 教授 濱島 義博, 教授 日笠 頼則学位規則第5条第2項該当Kyoto UniversityDA

Harmful Effects of Synthetic Surface-Active Detergents against Atopic Dermatitis

We report herein two cases of intractable atopic dermatitis successfully treated by simply avoiding the contact with surface-active detergents in the daily life and living. The detergents were closely related to the exacerbation and remission of the disease. Steroid ointment was no longer used. We discuss that the removal of horny layer lipids by surface-active detergents accelerates the transepidermal water loss and disturbs the barrier function of the epidermis and thus is intimately involved in the pathogenesis of atopic dermatitis

Vision-Based In-Hand Manipulation for Variously Shaped and Sized Objects by a Robotic Gripper With Active Surfaces

In-hand manipulation to translate and rotate an object is a challenging problem for robotic hands. As one solution, robotic hand with belts around fingers ( $active~surfaces$ ) has been developed for continuous and seamless manipulation. However, in practice, the grasped object can only be rotated through a small range less than 90° except the objects with simple shapes like cubes and cylinders. This is because the fingers cannot follow the width required not to drop the object or the desired rotation cannot be produced depending on its shape, leading to dropping the object or unable to rotate it anymore. This paper presents a method to address these problems and rotate objects of various shape and sizes through a large range of motion. A stereo camera is attached to a two-fingered robotic hand with belts. The changes in the contact points between the surfaces of the belts and object are predicted. Based on the prediction, the belts are controlled to adjust the angular velocity of the object such that the fingers can follow the width required to grasp it and the appropriate rotation can be produced. The fingers are controlled to follow the predicted contact points and deflect the belts to both cancel the unwanted rotation and generate the desired rotation. Through experiments in which 32 objects of 16 shapes and 2 sizes, and other real-world objects were rotated to 1 revolution, the rotational ranges for various objects were larger than in the other studies, confirming the validity of the proposed method

Measuring methods for temperature of the grinding wheel surface

For thermal analyzing on the grinding phenomenon, it is necessary to measure the temperature of microscopic area in very short time. There are two representative methods, one is the thermocouple method and another one is the infrared radiation thermometer. The new type of infrared radiation thermometer with optical fiber was developed in the response time and the measurable area. The minimum response time was 3×10^s and the diameter of measurable area was limited to just 110×10^m. Consequently, this thermometer measured the exact grinding temperature that correlated with calibration curves of S45C, grinding wheel (WA80) and compared with the results of thermocouple(alumel-S45C). The obtained temperature depended on the heat flow rate during the grinding operation and the oxidation of removed chips. The measured signal also indicated two parts, one was the base part and another was the impulse part. The heat energy generated by the oxidation was larger than the total amount of the energy supplied by the grinding operation