2,789 research outputs found
Comparative performance of squeeze film air journal bearings made of aluminium and copper
This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. Copyright @ 2012 The Authors - The article can be accessed from the links below.This article has been made available through the Brunel Open Access Publishing Fund.Two tubular squeeze film journal bearings, made from Al 2024 T3 and Cu C101, were excited by driving the single-layer piezoelectric actuators at a 75-V AC with a 75-V DC offset. The input excitation frequencies were coincident with the 13th modal frequency, at 16.32 and 12.18 kHz for the respective Al and Cu bearings, in order to produce a âtriangularâ modal shape. The paper also provided a CFX model, used to solve the Reynolds equation and the equation of motion, to explain the squeeze film effect of an oscillating plate with pressure end leakage. The dynamic characteristics of both bearings were studied in ANSYS and then validated by experiments with respect to their squeeze film thickness and load-carrying capacity. It was observed that whilst both bearings did levitate a load when excited at mode 13, the Al bearing showed a better floating performance than Cu bearing. This is due to the fact that the Al bearing had a higher modal frequency and a greater amplitude response than the Cu bearing.This article is made available through the Brunel Open Access Publishing Fund
Mitigating the disparity between theory and practice: EFL student teachersâ perspectives and experiences of their professional development
This study is a qualitative investigation that examines the perspectives and experiences of student teachers who become secondary-school English teachers in Japan. The initial teacher education (ITE) curriculum the teachers follow faces some problems, such as a too-short period of school-based training and a lack of clarity in goals and standards. This inquiry employs a case-study approach, using six cases created from interviews and journals that draw out unique perspectives on teachersâ professional development in ITE. The findings of the study indicate that student teachers are affected by various factors, including schooling experiences, theoretical knowledge in ITE coursework, practical teaching experiences in both formal classroom settings and informal settings beyond the curriculum. What also emerged from the qualitative data is student teachersâ struggle to adjust and apply theoretical knowledge to practical teaching experiences. Without systematic and consistent intervention from the ITE curriculum, they struggle to mitigate the disparity between theory and practice. They actively seek help for mediational means such as observing and emulating, which has been culturally endorsed in Japan, and interacting with experienced teachers and peers, rather than reconstructing their theories through directly testing their knowledge in a classroom. Furthermore, their individual struggle to find temporary solutions in mediating their teacher learning results in the variability of their experiences in ITE. The conclusion of the study is that the process of EFL student teachersâ professional development is not straightforward, as each mediational activity the teachers employ is not sufficient in itself. Working more closely with supervising teachers at schools, ITE in Japan should take a more significant role as a provider of appropriate and explicit mediation so that student teachers can develop their expertise as professional English teachers more efficiently and effectively
Yolk sac erythromyeloid progenitors expressing gain of function PTPN11 have functional features of JMML but are not sufficient to cause disease in mice
Background: Accumulating evidence suggests the origin of juvenile myelomonocytic leukemia (JMML) is closely associated with fetal development. Nevertheless, the contribution of embryonic progenitors to JMML pathogenesis remains unexplored. We hypothesized that expression of JMML-initiating PTPN11 mutations in HSC-independent yolk sac erythromyeloid progenitors (YS EMPs) would result in a mouse model of pediatric myeloproliferative neoplasm (MPN). Results: E9.5 YS EMPs from VavCre+;PTPN11D61Y embryos demonstrated growth hypersensitivity to granulocyte-macrophage colony-stimulating factor (GM-CSF) and hyperactive RAS-ERK signaling. Mutant EMPs engrafted the spleens of neonatal recipients, but did not cause disease. To assess MPN development during unperturbed hematopoiesis we generated CSF1R-MCM+;PTPN11E76K;ROSAYFP mice in which oncogene expression was restricted to EMPs. Yellow fluorescent protein-positive progeny of mutant EMPs persisted in tissues one year after birth and demonstrated hyperactive RAS-ERK signaling. Nevertheless, these mice had normal survival and did not demonstrate features of MPN. Conclusions: YS EMPs expressing mutant PTPN11 demonstrate functional and molecular features of JMML but do not cause disease following transplantation nor following unperturbed development
Analytical treatment of interacting Fermi gas in arbitrary dimensional harmonic trap
We study normal state properties of an interacting Fermi gas in an isotropic
harmonic trap of arbitrary dimensions. We exactly calculate the first-order
perturbation terms in the ground state energy and chemical potential, and
obtain simple analytic expressions of the total energy and chemical potential.
At zero temperature, we find that Thomas-Fermi approximation agrees well with
exact results for any dimension even though system is dilute and small, i.e.
when the Thomas-Fermi approximation is generally expected to fail. In the high
temperature (classical) region, we find interaction energy decreases in
proportion to T^(-d/2), where T is temperature and d is dimension of the
system. Effect of interaction in the ground state in two and three-dimensional
systems is also discussed.Comment: 15 pages, 4 figure
Electronic structure of the c(4 x 2) reconstructed Ge(001) surface
We investigate the electronic structure of the c(4 x 2) reconstructed Ge(001)
surface using band structure calculations based on density functional theory
and the generalized gradient approximation. In particular, we take into account
the details of surface reconstruction by means of well relaxed crystal
structures. The surface electronic states are identified and the local density
of states is compared to recent data from scanning tunneling spectroscopy. We
obtain almost perfect agreement between theory and experiment for both the
occupied and unoccupied states, which allows us to clarify the interpretation
of the experimental data.Comment: 4 pages, 3 figures, accepted by Chem. Phys. Let
Localized thinning for strain concentration in suspended germanium membranes and optical method for precise thickness measurement
We deposited Ge layers on (001) Si substrates by molecular beam epitaxy and used them to fabricate suspended membranes with high uniaxial tensile strain. We demonstrate a CMOS-compatible fabrication strategy to increase strain concentration and to eliminate the Ge buffer layer near the Ge/Si hetero-interface deposited at low temperature. This is achieved by a two-steps patterning and selective etching process. First, a bridge and neck shape is patterned in the Ge membrane, then the neck is thinned from both top and bottom sides. Uniaxial tensile strain values higher than 3% were measured by Raman scattering in a Ge membrane of 76 nm thickness. For the challenging thickness measurement on micrometer-size membranes suspended far away from the substrate a characterization method based on pump-and-probe reflectivity measurements was applied, using an asynchronous optical sampling technique.EC/FP7/628197/EU/Heat Propagation and Thermal Conductivity in Nanomaterials for Nanoscale Energy Management/HEATPRONAN
Temporal and spatial differences of methane flux at arctic tundra in Alaska
High latitude ecosystems were thought to enhance CH_4 emission in relation to the current arctic warming. However, we have little information about this potential feedback mechanisms on climate change, thus, model parameterization is insufficient and the observational data are required. We observed CH_4 flux at several types of tundra in Alaska over the growing seasons since 1995. From these observed data, we examined current CH_4 emission and its controlling factors on Alaskan tundra. Then we discussed about spatial and temporal differences in CH_4 flux. Daily trend of half hourly CH_4 flux had little relation with soil temperature, but the seasonal trend of daily flux changed with soil or water temperature. Cumulative CH_4 fluxes during the growing seasons were 8.1gCH_4m^(-2) on wet sedge tundra at Happy Valley in 1995, 3.3gCH_4m^(-2) on non-acidic moist tundra in 1996, and 3.58-8.24gCH_4m^(-2) on wet sedge tundra at Barrow between 1999-2003. Non-acidic tundra had low CH_4 emission with low CO_2 accumulation. There was large spatial difference in CH_4 flux caused by tundra type, and the large temporal difference at the wet sedge tundra reflected yearly weather variability
Response to Comment on: Meagher et al. Neutralization of Interleukin-16 Protects Nonobese Diabetic Mice From Autoimmune Type 1 Diabetes by a CCL4-Dependent Mechanism. Diabetes 2010;59:2862â2871
Pattern formation of reaction-diffusion system having self-determined flow in the amoeboid organism of Physarum plasmodium
The amoeboid organism, the plasmodium of Physarum polycephalum, behaves on
the basis of spatio-temporal pattern formation by local
contraction-oscillators. This biological system can be regarded as a
reaction-diffusion system which has spatial interaction by active flow of
protoplasmic sol in the cell. Paying attention to the physiological evidence
that the flow is determined by contraction pattern in the plasmodium, a
reaction-diffusion system having self-determined flow arises. Such a coupling
of reaction-diffusion-advection is a characteristic of the biological system,
and is expected to relate with control mechanism of amoeboid behaviours. Hence,
we have studied effects of the self-determined flow on pattern formation of
simple reaction-diffusion systems. By weakly nonlinear analysis near a trivial
solution, the envelope dynamics follows the complex Ginzburg-Landau type
equation just after bifurcation occurs at finite wave number. The flow term
affects the nonlinear term of the equation through the critical wave number
squared. Contrary to this, wave number isn't explicitly effective with lack of
flow or constant flow. Thus, spatial size of pattern is especially important
for regulating pattern formation in the plasmodium. On the other hand, the flow
term is negligible in the vicinity of bifurcation at infinitely small wave
number, and therefore the pattern formation by simple reaction-diffusion will
also hold. A physiological role of pattern formation as above is discussed.Comment: REVTeX, one column, 7 pages, no figur
Human platelet lysate improves human cord blood derived ECFC survival and vasculogenesis in three dimensional (3D) collagen matrices
Human cord blood (CB) is enriched in circulating endothelial colony forming cells (ECFCs) that display high proliferative potential and in vivo vessel forming ability. Since diminished ECFC survival is known to dampen the vasculogenic response in vivo, we tested how long implanted ECFC survive and generate vessels in three-dimensional (3D) type I collagen matrices in vitro and in vivo. We hypothesized that human platelet lysate (HPL) would promote cell survival and enhance vasculogenesis in the 3D collagen matrices. We report that the percentage of ECFC co-cultured with HPL that were alive was significantly enhanced on days 1 and 3 post-matrix formation, compared to ECFC alone containing matrices. Also, co-culture of ECFC with HPL displayed significantly more vasculogenic activity compared to ECFC alone and expressed significantly more pro-survival molecules (pAkt, p-Bad and Bcl-xL) in the 3D collagen matrices in vitro. Treatment with Akt1 inhibitor (A-674563), Akt2 inhibitor (CCT128930) and Bcl-xL inhibitor (ABT-263/Navitoclax) significantly decreased the cell survival and vasculogenesis of ECFC co-cultured with or without HPL and implicated activation of the Akt1 pathway as the critical mediator of the HPL effect on ECFC in vitro. A significantly greater average vessel number and total vascular area of human CD31(+) vessels were present in implants containing ECFC and HPL, compared to the ECFC alone implants in vivo. We conclude that implantation of ECFC with HPL in vivo promotes vasculogenesis and augments blood vessel formation via diminishing apoptosis of the implanted ECFC
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