水中における遷移金属NHC錯体による触媒的基質酸化反応

筑波大学 (University of Tsukuba)201

Health Support Provided by Yogo Teachers for Adolescent Female Students with a Thin Body Type

Purpose: To clarify the realities and challenges involved in health support provided by yogo teachers to adolescent girls who have a thin body type. Methods: A semi-structured interview survey was conducted with yogo teachers at a Japanese high school with experience of providing health support to thin adolescent female students and the results of the survey were subjected to qualitative analysis. Results: With regard to health support provided by yogo teachers, the results of analysis found that the actual situation consisted of the five categories of 【sharing information throughout the school organization to investigate methods of support】,【 realizing studentsʼ situations through the provision of individual support】, 【referring students and parents to specialist agencies】,【investigating collaborations with parents with students ʼ consent】, and 【carrying out prevention and awareness-raising activities about thin physiques】.　 However, the analysis also found that the practical challenges for providing such health support consisted of the six categories of 【working with parents to liaise with medical institutions】,【continuous support in collaboration with specialist agencies】,【 educational health support that enables all students to manage their own health】,【 yogo teachersʼ professional knowledge and assessment of eating disorders】,【 support methods that students can engage with on their own initiative, according to their situation】, and 【creating a counseling- friendly environment to facilitate early detection】.Discussion: While yogo teachers had an overall grasp of studentsʼ situations through their organizational engagements in cooperation with faculty and school physicians, as well as individual support activities, it was clear that they faced difficulties and challenges in relation to working together with parents and specialist agencies.　In the future, improving collaboration with parents will require that they, too, be encouraged to recognize that being excessively thin represents a health problem for adolescent female students.　In addition, it will also be necessary to work towards building daily collaboration systems, such as by having yogo teachers keep track of potential partner medical institutions as a matter of routine.　It was further suggested that yogo teachers will need to provide educational and preventive health support oriented toward helping female students acquire the ability to manage their own health

Case report: Novel NIPBL-BEND2 fusion gene identified in osteoblastoma-like phosphaturic mesenchymal tumor of the fibula

Phosphaturic mesenchymal tumor (PMT) is a rare tumor that secretes fibroblast growth factor 23 (FGF23) and causes hypophosphatemia and tumor-induced osteomalacia (TIO). Fusion genes FN1-FGFR1 and FN1-FGF1 have been detected in some PMTs, but the pathogenesis of PMTs without these fusion genes remains unclear. Here, we report a 12-year-old boy with persistent muscle weakness and gait disturbance. Roentgenographic examination revealed a radiolucent lesion with endosteal scalloping in the left fibula, while his serum level of FGF23 was markedly increased. Combined with simple X-ray findings of other body parts, we suspected that TIO was caused by PMT, and resected the tumor. After resection, the serum level of FGF23 started to decrease immediately and normalized within 3 hours after resection, with this being earlier than normalization of the serum phosphorus level. In RNA sequencing, FN1-FGFR1 and FN1-FGF1 were not detected, but a novel NIPBL-BEND2 fusion gene was identified. When we forcedly expressed this fusion gene in HEK293T cells and MG63 cells, cell proliferation was enhanced in both cell lines. Furthermore, Gene set enrichment analysis of HEK293T cells showed significant upregulation of MYC-target genes. Our results suggest that this novel NIPBL-BEND2 fusion gene promotes cell proliferation possibly via the MYC pathway and might be one of the etiologies of PMTs other than FN1-FGFR1 or FN1-FGF1

センダイシ オヨビ ナトリシ デ シハンサレル トリ ヒキニク カラノ サルモネラ ノ ケンシュツ ホウコク

本研究では、宮城県で調査報告の少ない鳥ひき肉におけるサルモネラの汚染状況を調査した。その結果、市販される鶏ひき肉55.2％にサルモネラの汚染が確認された。この汚染レベルは、全国レベルに匹敵し、鶏の育成場所や鳥肉処理場、ミンチ加工処理、包装などが違えども、同程度の汚染がみられた。またムネ肉とモモ肉では、汚染には差が認められなかった。販売店舗としては調査した11店舗中10店舗の鳥ひき肉でサルモネラ汚染は認められたが、直接培養で検出されないなど、その汚染菌数は少ない。さらに冷蔵や加熱などの食品に認められる損傷菌に関しても、今回分離したサルモネラの37.5％が損傷菌である可能性がある。ここ宮城県仙台市および名取市で市販される鳥ひき肉からもサルモネラ菌の汚染が示されたことから、鳥ひき肉の調理や取り扱いにも十分注意することを強調したい