Clinical and histological observations of chorioepithelioma and hydatidiform mole

1. Clinical and histological evaluation of so-called chorioepithelioma malignum and hydatidiform mole has been made on the cases treated at the Department of Obstetrics and Gynecology, Okayama University Hospital during the 20year period friom 1939 to 1958. 2. CC has been confirmed to be a poor risk in the treatment than CA and SE. 3. The two-year cure rate and the five-year cure rate yield an approximate value in each of CC, CA and SE, so that the two-year survival would be an ideal index for determination of the prognosis. 4. It may be pointed out that CC would indicate a tendency of a higher gonadotropin content suggestive of the poor prognosis, provided the disease contain a greater number of La-cells comparing to Sy-cells. 5. Metastasis of CA is not so infrequent as has been formerly believed, and there were two cases, which proved to be a typical SE and had metastasis to the vaginal wall. 6. Concerning the last labor preceding the chorioepithelioma, it has been clarified that the disease occurs more frequently following spontaneous abortion rather than after artificial abortion. 7. It is noted that the mole showing a marked proliferation of the trophoblasts entailed CC. However, in order to evaluate a correlation of the histological findings of the mole with chance occurrence of the subsquent CC, further study on the cases is required.</p

Altered balance of inhibitory and active Fc gamma receptors in murine autoimmune glomerulonephritis

Mag is an MRL-derived glomerulonephritis susceptibility locus that includes the Fcgr2b and Fcgr3 genes encoding the inhibitory Fc gamma receptor IIB (FcγRIIB) and active FcγRIII, respectively. We measured changes in gene balance in three B6.MRLc1 congenic mouse strains containing the 82-86, 92–100 and 100 cM regions of the MRL chromosome 1. We found that only the strain that has 92-100 (which includes Fcgr loci) developed glomerulonephritis. These congenic mice had splenomegaly, elevated blood urea nitrogen, anti-dsDNA antibodies and higher urinary albumin excretion compared to the parental strain C57BL/6(B6). Prior to the development of glomerulonephritis, large CD3- (T cell) and B220- (B cell) positive areas were identified in the spleens of B6.MRLc1(92–100) mice. Both Fc receptors were found in mesangial and dendritic cells; important sites of immune-complex clearance and antigen presentation. The FcγRIII-positive areas were more prominent in the congenic strain. Fcgr2b mRNA was lower in the B6.MRLc1(92–100) kidney and spleen than in those organs of the B6 mice while Fcgr3 expression and the Fcgr3 to Fcgr2b mRNA ratio was higher in the congenic strain kidneys, spleen and thymus than in those of the B6 prior to and at an early stage of glomerulonephritis. We conclude that the imbalance of inhibitory and active Fc gamma receptors influences the pathogenesis of glomerulonephritis

Molecular Pathology of Murine Ureteritis Causing Obstructive Uropathy with Hydronephrosis

Primary causes of urinary tract obstruction that induces urine retention and results in hydronephrosis include uroliths, inflammation, and tumors. In this study, we analyzed the molecular pathology of ureteritis causing hydronephrosis in laboratory rodents

Solvation of Lithium Irons in Mixed Organic Electrolyte Solutions by Electrospray Ionization Mass Spectroscopy

Solvation of lithium ions in mixed organic electrolyte solutions for secondary lithium batteries was investigated by electrospray ionization mass spectroscopy. The electrolyte solutions were mixed binary solutions of diethyl carbonate (DEC), dimethyl carbonate (DMC), ethylene carbonate (EC),γ-butyrolactone (GBL), and propylene carbonate (PC) containing LiClO4. Lithium ions solvated mainly to two solvent molecules. The order of the inclination of the solvent molecules solvating to lithium ions is PC > EC ≒　GBL　>>　DEC > DMC

Studies on Solvation of Lithium Ions in Organic Electrolyte Solutions by Electrospray Ionization-Mass Spectroscopy

Solvation of lithium ions in organic electrolyte solutions, ethylene carbonate (EC), propylene carbonate (PC), and gamma-butyrolactone (GBL) containing LiClO4, for lithium batteries was studied by electrospray ionization-mass spectroscopy (ESI-MS). The mass spectrograms showed that a lithium ion solvated with two or three solvent molecules

Production of doubly strange hypernuclei via {\Xi}- doorways in the 16O(K-, K+) reaction at 1.8 GeV/c

We examine theoretically production of doubly strange hypernuclei, 16 {\Xi}-C and 16 {\Lambda}{\Lambda}C, in doublecharge exchange 16O(K-, K+) reactions using a distorted-wave impulse approximation. The inclusive K+ spectrum at the incident momentum pK- = 1.8 GeV/c and scattering angle {\theta}lab = 0^{\circ} is estimated in a one-step mechanism, K-p \to K+{\Xi}- via {\Xi}- doorways caused by a {\Xi}-p-{\Lambda}{\Lambda} coupling. The calculated spectrum in the {\Xi}- bound region indicates that the integrated cross sections are on the order of 7-12 nb/sr for significant 1- excited states with 14C(0+, 2+) \otimes s{\Lambda}p{\Lambda} configurations in 16 {\Lambda}{\Lambda}C via the doorway states of the spin-stretched 15N(1/2-, 3/2-) \otimes s{\Xi}- in 16 {\Xi}-C due to a high momentum transfer q{\Xi}- \approx 400 MeV/c. The {\Xi}- admixture probabilities of these states are on the order of 5-9%. However, populations of the 0+ ground state with 14C(0+) \otimes s2{\Lambda} and the 2+ excited state with 14C(2+) \otimes s2 {\Lambda} are very small. The sensitivity of the spectrum on the {\Xi}N-{\Lambda}{\Lambda} coupling strength enables us to extract the nature of {\Xi}N-{\Lambda}{\Lambda} dynamics in nuclei, and the nuclear (K-, K+) reaction can extend our knowledge of the S = -2 world.Comment: 10 pages, 3 figure

Association between shift work and the risk of death from biliary tract cancer in Japanese men

Background: There is increasing evidence suggesting that shift work involving night work may increase cancer risk. Methods: We examined the association between working rotating shifts and the risk of death from biliary tract cancer among Japanese men who participated in the Japan Collaborative Cohort Study. Of the 46, 395 men recruited, 22, 224 men aged 40-65 at baseline (1988-1990) who reported working full-time or were self-employed were included in the present analysis. The study subjects were followed through December 31, 2009. Information regarding occupation and lifestyle factors was collected using a self-administered questionnaire. Cox proportional hazard models were used to estimate the hazard ratio (HR) and 95 % confidence interval (CI) for the risk of death from biliary tract cancer in relation to shift work. Results: During a mean 17-year follow-up, we observed 94 biliary tract cancer deaths, including 23 deaths from gallbladder cancer and 71 deaths from extrahepatic bile duct cancer. Overall, shift work was associated with a statistically non-significant increase in the risk of biliary tract cancer, with an HR of 1.50 (95 % CI: 0.81-2.77), among rotating shift workers. When the analysis was limited to extrahepatic bile duct cancer, a significant association appeared, with a multivariable-adjusted HR of 1.93 (95 % CI: 1.00-3.72) for rotating shift workers. Conclusion: Our data indicate that shift work may be associated with increased risk of death from extrahepatic bile duct cancer in this cohort of Japanese men. The association with gallbladder cancer remains unclear because of the small number of deaths