Potential and efficiency of statistical learning closely intertwined with individuals’ executive functions: A mathematical modeling study

Statistical learning (SL) is essential in enabling humans to extract probabilistic regularities from the world. The ability to accomplish ultimate learning performance with training (i.e., the potential of learning) has been known to be dissociated with performance improvement per amount of learning time (i.e., the efficiency of learning). Here, we quantified the potential and efficiency of SL separately through mathematical modeling and scrutinized how they were affected by various executive functions. Our results showed that a high potential of SL was associated with poor inhibition and good visuo-spatial working memory, whereas high efficiency of SL was closely related to good inhibition and good set-shifting. We unveiled the distinct characteristics of SL in relation to potential and efficiency and their interaction with executive functions

Local and global energy barriers for chiral domain walls in synthetic antiferromagnet-ferromagnet lateral junctions

Of great promise are synthetic antiferromagnet-based racetrack devices in which chiral composite domain walls can be efficiently moved by current. However, overcoming the trade-off between energy efficiency and thermal stability remains a major challenge. Here we show that chiral domain walls in a synthetic antiferromagnet-ferromagnet lateral junction are highly stable against large magnetic fields, while the domain walls can be efficiently moved across the junction by current. Our approach takes advantage of field-induced global energy barriers in the unique energy landscape of the junction that are added to the local energy barrier. We demonstrate that thermal fluctuations are equivalent to the magnetic field effect, thereby, surprisingly, increasing the energy barrier and further stabilizing the domain wall in the junction at higher temperatures, which is in sharp contrast to ferromagnets or synthetic antiferromagnets. We find that the threshold current density can be further decreased by tilting the junction without affecting the high domain wall stability. Furthermore, we demonstrate that chiral domain walls can be robustly confined within a ferromagnet region sandwiched on both sides by synthetic antiferromagnets and yet can be readily injected into the synthetic antiferromagnet regions by current. Our findings break the aforementioned trade-off, thereby allowing for versatile domain-wall-based memory, and logic, and beyond

Algae Metabolites in Cosmeceutical: An Overview of Current Applications and Challenges

Cosmetics are widely used by people around the world to protect the skin from external stimuli. Consumer preference towards natural cosmetic products has increased as the synthetic cosmetic products caused adverse side effects and resulted in low absorption rate due to the chemicals’ larger molecular size. The cosmetic industry uses the term “cosmeceutical”, referring to a cosmetic product that is claimed to have medicinal or drug-like benefits. Marine algae have gained tremendous attention in cosmeceuticals. They are one of the richest marine resources considered safe and possessed negligible cytotoxicity effects on humans. Marine algae are rich in bioactive substances that have shown to exhibit strong benefits to the skin, particularly in overcoming rashes, pigmentation, aging, and cancer. The current review provides a detailed survey of the literature on cosmeceutical potentials and applications of algae as skin whitening, anti-aging, anticancer, antioxidant, anti-inflammation, and antimicrobial agents. The biological functions of algae and the underlying mechanisms of all these activities are included in this review. In addition, the challenges of using algae in cosmeceutical applications, such as the effectiveness of different extraction methods and processing, quality assurance, and regulations concerning extracts of algae in this sector were also discussed

Cosmic-Ray Proton and Helium Spectra from the First CREAM Flight

Cosmic-ray proton and helium spectra have been measured with the balloon-borne Cosmic Ray Energetics And Mass experiment flown for 42 days in Antarctica in the 2004-2005 austral summer season. High-energy cosmic-ray data were collected at an average altitude of ~38.5 km with an average atmospheric overburden of ~3.9 g cm$^{-2}$. Individual elements are clearly separated with a charge resolution of ~0.15 e (in charge units) and ~0.2 e for protons and helium nuclei, respectively. The measured spectra at the top of the atmosphere are represented by power laws with a spectral index of -2.66 $\pm$ 0.02 for protons from 2.5 TeV to 250 TeV and -2.58 $\pm$ 0.02 for helium nuclei from 630 GeV/nucleon to 63 TeV/nucleon. They are harder than previous measurements at a few tens of GeV/nucleon. The helium flux is higher than that expected from the extrapolation of the power law fitted to the lower-energy data. The relative abundance of protons to helium nuclei is 9.1 $\pm$ 0.5 for the range from 2.5 TeV/nucleon to 63 TeV/nucleon. This ratio is considerably smaller than the previous measurements at a few tens of GeV/nucleon.Comment: 20 pages, 4 figure

Proton and Helium Spectra from the CREAM-III Flight

Primary cosmic-ray elemental spectra have been measured with the balloon-borne Cosmic Ray Energetics And Mass (CREAM) experiment since 2004. The third CREAM payload (CREAM-III) flew for 29 days during the 2007-2008 Antarctic season. Energies of incident particles above 1 TeV are measured with a calorimeter. Individual elements are clearly separated with a charge resolution of ~0.12 e (in charge units) and ~0.14 e for protons and helium nuclei, respectively, using two layers of silicon charge detectors. The measured proton and helium energy spectra at the top of the atmosphere are harder than other existing measurements at a few tens of GeV. The relative abundance of protons to helium nuclei is 9.53+-0.03 for the range of 1 TeV/n to 63 TeV/n. The ratio is considerably smaller than other measurements at a few tens of GeV/n. The spectra become softer above ~20 TeV. However, our statistical uncertainties are large at these energies and more data are needed

Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions

The gut microbiota has an important role in the gut barrier, inflammation and metabolic functions. Studies have identified a close association between the intestinal barrier and metabolic diseases, including obesity and type 2 diabetes (T2D). Recently, Akkermansia muciniphila has been reported as a beneficial bacterium that reduces gut barrier disruption and insulin resistance. Here we evaluated the role of A. muciniphila-derived extracellular vesicles (AmEVs) in the regulation of gut permeability. We found that there are more AmEVs in the fecal samples of healthy controls compared with those of patients with T2D. In addition, AmEV administration enhanced tight junction function, reduced body weight gain and improved glucose tolerance in high-fat diet (HFD)-induced diabetic mice. To test the direct effect of AmEVs on human epithelial cells, cultured Caco-2 cells were treated with these vesicles. AmEVs decreased the gut permeability of lipopolysaccharide-treated Caco-2 cells, whereas Escherichia coli-derived EVs had no significant effect. Interestingly, the expression of occludin was increased by AmEV treatment. Overall, these results imply that AmEVs may act as a functional moiety for controlling gut permeability and that the regulation of intestinal barrier integrity can improve metabolic functions in HFD-fed mice.11Ysciescopuskc

Elemental energy spectra of cosmic rays measured by CREAM-II

We present new measurements of the energy spectra of cosmic-ray (CR) nuclei from the second flight of the balloon-borne experiment CREAM (Cosmic Ray Energetics And Mass). The instrument (CREAM-II) was comprised of detectors based on different techniques (Cherenkov light, specific ionization in scintillators and silicon sensors) to provide a redundant charge identification and a thin ionization calorimeter capable of measuring the energy of cosmic rays up to several hundreds of TeV. The data analysis is described and the individual energy spectra of C, O, Ne, Mg, Si and Fe are reported up to ~ 10^14 eV. The spectral shape looks nearly the same for all the primary elements and can be expressed as a power law in energy E^{-2.66+/-0.04}. The nitrogen absolute intensity in the energy range 100-800 GeV/n is also measured.Comment: 4 pages, 3 figures, presented at ICRC 2009, Lodz, Polan

Measurements of cosmic-ray energy spectra with the 2nd CREAM flight

During its second Antarctic flight, the CREAM (Cosmic Ray Energetics And Mass) balloon experiment collected data for 28 days, measuring the charge and the energy of cosmic rays (CR) with a redundant system of particle identification and an imaging thin ionization calorimeter. Preliminary direct measurements of the absolute intensities of individual CR nuclei are reported in the elemental range from carbon to iron at very high energy.Comment: 4 pages, 3 figures, presented at XV International Symposium on Very High Energy Cosmic Ray Interactions (ISVHECRI 2008