661 research outputs found
New Uropodina records and species from the Korean Peninsula (Acari: Mesostigmata)
Thirteen Mesostigmata species are recorded from the Korean Peninsula. Two of them Nenteria koreana and Leonardiella koreana spp. nov. are new to science, and further eleven species are recorded for the first time from the Korean Peninsula
Further insights into the allan-herndon-dudley syndrome: Clinical and functional characterization of a novel MCT8 mutation
Background. Mutations in the thyroid hormone (TH) transporter MCT8 have been identified as the cause for Allan-Herndon-Dudley Syndrome (AHDS), characterized by severe psychomotor retardation and altered TH serum levels. Here we report a novel MCT8 mutation identified in 4 generations of one family, and its functional characterization. Methods. Proband and family members were screened for 60 genes involved in X-linked cognitive impairment and the MCT8 mutation was confirmed. Functional consequences of MCT8 mutations were studied by analysis of [125I]TH transport in fibroblasts and transiently transfected JEG3 and COS1 cells, and by subcellular localization of the transporter. Results. The proband and a male cousin demonstrated clinical findings characteristic of AHDS. Serum analysis showed high T3, low rT3, and normal T4 and TSH levels in the proband. A MCT8 mutation (c.869C>T; p.S290F) was identified in the proband, his cousin, and several female carriers. Functional analysis of the S290F mutant showed decreased TH transport, metabolism and protein expression in the three cell types, whereas the S290A mutation had no effect. Interestingly, both uptake and efflux of T3 and T4 was impaired in fibroblasts of the proband, compared to his healthy brother. However, no effect of the S290F mutation was observed on TH efflux from COS1 and JEG3 cells. Immunocytochemistry showed plasma membrane localization of wild-type MCT8 and the S290A and S290F mutants in JEG3 cells. Conclusions. We describe a novel MCT8 mutation (S290F) in 4 generations of a family with Allan-Herndon-Dudley Syndrome. Functional analysis demonstrates loss-of-function of the MCT8 transporter. Furthermore, our results indicate that the function of the S290F mutant is dependent on cell context. Comparison of the S290F and S290A mutants indicates that it is not the loss of Ser but its substitution with Phe, which leads to S290F dysfunction
Boundary Effects on Dynamic Behavior of Josephson-Junction Arrays
The boundary effects on the current-voltage characteristics in
two-dimensional arrays of resistively shunted Josephson junctions are examined.
In particular, we consider both the conventional boundary conditions (CBC) and
the fluctuating twist boundary conditions (FTBC), and make comparison of the
obtained results. It is observed that the CBC, which have been widely adopted
in existing simulations, may give a problem in scaling, arising from rather
large boundary effects; the FTBC in general turn out to be effective in
reducing the finite-size effects, yielding results with good scaling behavior.
To resolve the discrepancy between the two boundary conditions, we propose that
the proper scaling in the CBC should be performed with the boundary data
discarded: This is shown to give results which indeed scale well and are the
same as those from the FTBC.Comment: RevTex, Final version to appear in Phys. Rev.
First-order interference of nonclassical light emitted spontaneously at different times
We study first-order interference in spontaneous parametric down-conversion
generated by two pump pulses that do not overlap in time. The observed
modulation in the angular distribution of the signal detector counting rate can
only be explained in terms of a quantum mechanical description based on
biphoton states. The condition for observing interference in the signal channel
is shown to depend on the parameters of the idler radiation.Comment: 5 pages, two-column, submitted to PR
Track Reconstruction and Performance of DRIFT Directional Dark Matter Detectors using Alpha Particles
First results are presented from an analysis of data from the DRIFT-IIa and
DRIFT-IIb directional dark matter detectors at Boulby Mine in which alpha
particle tracks were reconstructed and used to characterise detector
performance--an important step towards optimising directional technology. The
drift velocity in DRIFT-IIa was [59.3 +/- 0.2 (stat) +/- 7.5 (sys)] m/s based
on an analysis of naturally-occurring alpha-emitting background. The drift
velocity in DRIFT-IIb was [57 +/- 1 (stat) +/- 3 (sys)] m/s determined by the
analysis of alpha particle tracks from a Po-210 source. 3D range reconstruction
and energy spectra were used to identify alpha particles from the decay of
Rn-222, Po-218, Rn-220 and Po-216. This study found that (22 +/- 2)% of Po-218
progeny (from Rn-222 decay) are produced with no net charge in 40 Torr CS2. For
Po-216 progeny (from Rn-220 decay) the uncharged fraction is (100 +0 -35)%.Comment: 27 pages, 12 figures, 5 tables. Submitted to Nuclear Instruments and
Methods in Physics Research, Section A. Subj-class: Instrumentation and
Detector
Orientational pinning and transverse voltage: Simulations and experiments in square Josephson junction arrays
We study the dependence of the transport properties of square Josephson
Junctions arrays with the direction of the applied dc current, both
experimentally and numerically. We present computational simulations of
current-voltage curves at finite temperatures for a single vortex in the array
(), and experimental measurements in
arrays under a low magnetic field corresponding to . We find that
the transverse voltage vanishes only in the directions of maximum symmetry of
the square lattice: the [10] and [01] direction (parallel bias) and the [11]
direction (diagonal bias). For orientations different than the symmetry
directions, we find a finite transverse voltage which depends strongly on the
angle of the current. We find that vortex motion is pinned in the [10]
direction (), meaning that the voltage response is insensitive to small
changes in the orientation of the current near . We call this
phenomenon orientational pinning. This leads to a finite transverse critical
current for a bias at and to a transverse voltage for a bias at
. On the other hand, for diagonal bias in the [11] direction the
behavior is highly unstable against small variations of , leading to a
rapid change from zero transverse voltage to a large transverse voltage within
a few degrees. This last behavior is in good agreement with our measurements in
arrays with a quasi-diagonal current drive.Comment: 9 pages, 9 figure
Synchronization and resonance in a driven system of coupled oscillators
We study the noise effects in a driven system of globally coupled
oscillators, with particular attention to the interplay between driving and
noise. The self-consistency equation for the order parameter, which measures
the collective synchronization of the system, is derived; it is found that the
total order parameter decreases monotonically with noise, indicating overall
suppression of synchronization. Still, for large coupling strengths, there
exists an optimal noise level at which the periodic (ac) component of the order
parameter reaches its maximum. The response of the phase velocity is also
examined and found to display resonance behavior.Comment: 17 pages, 3 figure
Interferometric Bell-state preparation using femtosecond-pulse-pumped Spontaneous Parametric Down-Conversion
We present theoretical and experimental study of preparing maximally
entangled two-photon polarization states, or Bell states, using femtosecond
pulse pumped spontaneous parametric down-conversion (SPDC). First, we show how
the inherent distinguishability in femtosecond pulse pumped type-II SPDC can be
removed by using an interferometric technique without spectral and amplitude
post-selection. We then analyze the recently introduced Bell state preparation
scheme using type-I SPDC. Theoretically, both methods offer the same results,
however, type-I SPDC provides experimentally superior methods of preparing Bell
states in femtosecond pulse pumped SPDC. Such a pulsed source of highly
entangled photon pairs is useful in quantum communications, quantum
cryptography, quantum teleportation, etc.Comment: 11 pages, two-column format, to appear in PR
Divergent consensuses on Arctic amplification influence on midlatitude severe winter weather
The article of record as published may be found at https://doi.org/10.1038/s41558-019-0662-yWe thank R. Blackport, C. Deser, L. Sun, J. Screen and D. Smith for discussions and
suggested revisions to the manuscript. We also thank J. Screen and L. Sun for model data.
A. Amin helped to create Fig. 2. US CLIVAR logistically and financially supported the
Arctic-Midlatitude Working Group and Arctic Change and its Influence on Mid-Latitude
Climate and Weather workshop that resulted in this article. J.C. is supported by the US
National Science Foundation grants AGS-1657748 and PLR-1504361, 1901352. M.W.
acknowledges funding by the Deutsche Forschungsgemeinschaft project no. 268020496–
TRR 172, within the Transregional Collaborative Research Center “Arctic Amplification:
Climate Relevant Atmospheric and Surface Processes, and Feedback Mechanisms (AC)3
”.
T.V. was supported by the Academy of Finland grant 317999. J.O. was supported by the
NOAA Arctic Research Program. J.F. was supported by the Woods Hole Research Center.
S.W. and H.G. are supported by the US DOE Award Number DE-SC0016605. J.Y. was
supported by the Korea Meteorological Administration Research and Development
Program under grant KMI2018-01015 and National Research Foundation grant
NRF_2017R1A2B4007480. D.H. is supported by the Helmholtz Association of German
Research Centers (grant FKZ HRSF-0036, project POLEX). The authors acknowledge the
World Climate Research Programme’s Working Group on Coupled Modelling, which is
responsible for CMIP, and thank the climate modelling groups (listed in Supplementary
Table 1) for producing and making available their model output. For CMIP, the US
Department of Energy’s PCMDI provides coordinating support and led development of
software infrastructure in partnership with the Global Organization for Earth System
Science Portals.The Arctic has warmed more than twice as fast as the global average since the late twentieth century, a phenomenon known as
Arctic amplification (AA). Recently, there have been considerable advances in understanding the physical contributions to AA,
and progress has been made in understanding the mechanisms that link it to midlatitude weather variability. Observational
studies overwhelmingly support that AA is contributing to winter continental cooling. Although some model experiments sup port the observational evidence, most modelling results show little connection between AA and severe midlatitude weather or
suggest the export of excess heating from the Arctic to lower latitudes. Divergent conclusions between model and observational
studies, and even intramodel studies, continue to obfuscate a clear understanding of how AA is influencing midlatitude weather
Multifunctional Magnetic-fluorescent Nanocomposites for Biomedical Applications
Nanotechnology is a fast-growing area, involving the fabrication and use of nano-sized materials and devices. Various nanocomposite materials play a number of important roles in modern science and technology. Magnetic and fluorescent inorganic nanoparticles are of particular importance due to their broad range of potential applications. It is expected that the combination of magnetic and fluorescent properties in one nanocomposite would enable the engineering of unique multifunctional nanoscale devices, which could be manipulated using external magnetic fields. The aim of this review is to present an overview of bimodal “two-in-one” magnetic-fluorescent nanocomposite materials which combine both magnetic and fluorescent properties in one entity, in particular those with potential applications in biotechnology and nanomedicine. There is a great necessity for the development of these multifunctional nanocomposites, but there are some difficulties and challenges to overcome in their fabrication such as quenching of the fluorescent entity by the magnetic core. Fluorescent-magnetic nanocomposites include a variety of materials including silica-based, dye-functionalised magnetic nanoparticles and quantum dots-magnetic nanoparticle composites. The classification and main synthesis strategies, along with approaches for the fabrication of fluorescent-magnetic nanocomposites, are considered. The current and potential biomedical uses, including biological imaging, cell tracking, magnetic bioseparation, nanomedicine and bio- and chemo-sensoring, of magnetic-fluorescent nanocomposites are also discussed
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