1,313 research outputs found
Magnetic-field-induced ab-plane rotation of the Eu magnetic moments in trigonal EuMg2Bi2 and EuMg2Sb2 single crystals below their Neel temperatures
The thermodynamic and electronic-transport properties of trigonal EuMg2Bi2 in
ab-plane magnetic fields Hx and the A-type antiferromagnetic structure have
recently been reported. At a temperature of 1.8 K < TN, the Eu magnetic moments
with spin S = 7/2 remain locked in the ab plane up to and above the ab-plane
critical field Hxc = 27.5 kOe at which the Eu moments become parallel to Hx.
Here additional measurements at low fields are reported that reveal a new
spin-reorientation transition at a field Hc1 = 465 Oe where the Eu moments
remain in the ab plane but become perpendicular to Hx. At higher fields, the
moments cant towards the field resulting in M proportional to Hx up to Hxc.
Similar results are reported from measurements of the magnetic properties of
EuMg2Sb2 single crystals, where Hc1 = 220 Oe is found. Theory is formulated
that models the low-field magnetic behavior of both materials, and the
associated anisotropies are calculated. The ab-plane trigonal anisotropy in
EuMg2Sb2 is found to be significantly smaller than in EuMg2Bi2.Comment: 11 pages, 10 captioned figures, 3 tables, 25 reference
The moduli space of regular stable maps
The moduli space of regular stable maps with values in a complex manifold
admits naturally the structure of a complex orbifold. Our proof uses the
methods of differential geometry rather than algebraic geometry. It is based on
Hardy decompositions and Fredholm intersection theory in the loop space of the
target manifold.Comment: 59 pages, 2 figure
Ab initio modeling of oxygen impurity atom incorporation into uranium mononitride surface and subsurface vacancies
The incorporation of oxygen atoms has been simulated into either nitrogen or
uranium vacancy at the UN(001) surface, sub-surface or central layers. For
calculations on the corresponding slab models both the relativistic
pseudopotentials and the method of projector augmented-waves (PAW) as
implemented in the VASP computer code have been used. The energies of O atom
incorporation and solution within the defective UN surface have been calculated
and discussed. For different configurations of oxygen ions at vacancies within
the UN(001) slab, the calculated density of states and electronic charge
re-distribution was analyzed. Considerable energetic preference of O atom
incorporation into the N-vacancy as compared to U-vacancy indicates that the
observed oxidation of UN is determined mainly by the interaction of oxygen
atoms with the surface and sub-surface N vacancies resulting in their capture
by the vacancies and formation of O-U bonds with the nearest uranium atoms.
Keywords: Density functional calculations, uranium mononitride, surface,
defects, N and U vacancie
Birational cobordism invariance of uniruled symplectic manifolds
A symplectic manifold is called {\em (symplectically) uniruled}
if there is a nonzero genus zero GW invariant involving a point constraint. We
prove that symplectic uniruledness is invariant under symplectic blow-up and
blow-down. This theorem follows from a general Relative/Absolute correspondence
for a symplectic manifold together with a symplectic submanifold. A direct
consequence is that symplectic uniruledness is a symplectic birational
invariant. Here we use Guillemin and Sternberg's notion of cobordism as the
symplectic analogue of the birational equivalence.Comment: To appear in Invent. Mat
Social Determinants of Community Health Services Utilization among the Users in China: A 4-Year Cross-Sectional Study
Background To identify social factors determining the frequency of community health service (CHS) utilization among CHS users in China. Methods Nationwide cross-sectional surveys were conducted in 2008, 2009, 2010, and 2011. A total of 86,116 CHS visitors selected from 35 cities were interviewed. Descriptive analysis and multinomial logistic regression analysis were employed to analyze characteristics of CHS users, frequency of CHS utilization, and the socio-demographic and socio-economic factors influencing frequency of CHS utilization. Results Female and senior CHS clients were more likely to make 3–5 and ≥6 CHS visits (as opposed to 1–2 visits) than male and young clients, respectively. CHS clients with higher education were less frequent users than individuals with primary education or less in 2008 and 2009; in later surveys, CHS clients with higher education were the more frequent users. The association between frequent CHS visits and family income has changed significantly between 2008 and 2011. In 2011, income status did not have a discernible effect on the likelihood of making ≥6 CHS visits, and it only had a slight effect on making 3–5 CHS visits. Conclusion CHS may play an important role in providing primary health care to meet the demands of vulnerable populations in China. Over time, individuals with higher education are increasingly likely to make frequent CHS visits than individuals with primary school education or below. The gap in frequency of CHS utilization among different economic income groups decreased from 2008 to 2011
Longer telomere length in peripheral white blood cells is associated with risk of lung cancer and the rs2736100 (CLPTM1L-TERT) polymorphism in a prospective cohort study among women in China.
A recent genome-wide association study of lung cancer among never-smoking females in Asia demonstrated that the rs2736100 polymorphism in the TERT-CLPTM1L locus on chromosome 5p15.33 was strongly and significantly associated with risk of adenocarcinoma of the lung. The telomerase gene TERT is a reverse transcriptase that is critical for telomere replication and stabilization by controlling telomere length. We previously found that longer telomere length measured in peripheral white blood cell DNA was associated with increased risk of lung cancer in a prospective cohort study of smoking males in Finland. To follow up on this finding, we carried out a nested case-control study of 215 female lung cancer cases and 215 female controls, 94% of whom were never-smokers, in the prospective Shanghai Women's Health Study cohort. There was a dose-response relationship between tertiles of telomere length and risk of lung cancer (odds ratio (OR), 95% confidence interval [CI]: 1.0, 1.4 [0.8-2.5], and 2.2 [1.2-4.0], respectively; P trend = 0.003). Further, the association was unchanged by the length of time from blood collection to case diagnosis. In addition, the rs2736100 G allele, which we previously have shown to be associated with risk of lung cancer in this cohort, was significantly associated with longer telomere length in these same study subjects (P trend = 0.030). Our findings suggest that individuals with longer telomere length in peripheral white blood cells may have an increased risk of lung cancer, but require replication in additional prospective cohorts and populations
Landau-Ginzburg/Calabi-Yau correspondence, global mirror symmetry and Orlov equivalence
We show that the Gromov-Witten theory of Calabi-Yau hypersurfaces matches, in
genus zero and after an analytic continuation, the quantum singularity theory
(FJRW theory) recently introduced by Fan, Jarvis and Ruan following ideas of
Witten. Moreover, on both sides, we highlight two remarkable integral local
systems arising from the common formalism of Gamma-integral structures applied
to the derived category of the hypersurface {W=0} and to the category of graded
matrix factorizations of W. In this setup, we prove that the analytic
continuation matches Orlov equivalence between the two above categories.Comment: 72pages, v2: Appendix B and references added. Typos corrected, v3:
several mistakes corrected, final versio
Hedgehog-Regulated Ubiquitination Controls Smoothened Trafficking and Cell Surface Expression in Drosophila
Hedgehog transduces signal by promoting cell surface expression of the seven-transmembrane protein Smoothened (Smo) in Drosophila, but the underlying mechanism remains unknown. Here we demonstrate that Smo is downregulated by ubiquitin-mediated endocytosis and degradation, and that Hh increases Smo cell surface expression by inhibiting its ubiquitination. We find that Smo is ubiquitinated at multiple Lysine residues including those in its autoinhibitory domain (SAID), leading to endocytosis and degradation of Smo by both lysosome- and proteasome-dependent mechanisms. Hh inhibits Smo ubiquitination via PKA/CK1-mediated phosphorylation of SAID, leading to Smo cell surface accumulation. Inactivation of the ubiquitin activating enzyme Uba1 or perturbation of multiple components of the endocytic machinery leads to Smo accumulation and Hh pathway activation. In addition, we find that the non-visual β-arrestin Kurtz (Krz) interacts with Smo and acts in parallel with ubiquitination to downregulate Smo. Finally, we show that Smo ubiquitination is counteracted by the deubiquitinating enzyme UBPY/USP8. Gain and loss of UBPY lead to reciprocal changes in Smo cell surface expression. Taken together, our results suggest that ubiquitination plays a key role in the downregulation of Smo to keep Hh pathway activity off in the absence of the ligand, and that Hh-induced phosphorylation promotes Smo cell surface accumulation by inhibiting its ubiquitination, which contributes to Hh pathway activation
Genetic mapping and evolutionary analysis of human-expanded cognitive networks
Cognitive brain networks such as the default-mode network (DMN), frontoparietal network, and salience network, are key functional networks of the human brain. Here we show that the rapid evolutionary cortical expansion of cognitive networks in the human brain, and most pronounced the DMN, runs parallel with high expression of human-accelerated genes (HAR genes). Using comparative transcriptomics analysis, we present that HAR genes are differentially more expressed in higher-order cognitive networks in humans compared to chimpanzees and macaques and that genes with high expression in the DMN are involved in synapse and dendrite formation. Moreover, HAR and DMN genes show significant associations with individual variations in DMN functional activity, intelligence, sociability, and mental conditions such as schizophrenia and autism. Our results suggest that the expansion of higher-order functional networks subserving increasing cognitive properties has been an important locus of genetic changes in recent human brain evolution
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