1,201 research outputs found
Observable effects of the quantum adiabatic phase for noncyclic evolution
Journal ArticleIt is pointed out that, contrary to naive expectation, the gauge structure or Berry connection recently found in slowly varying quantum systems gives rise to observable effects even for noncyclic evolutions corresponding to open paths in parameter space. We propose to test such effects in muon spin resonance and in level-crossing resonance in muon-spin-rotation spectroscopy. In our proposals either the probe or the system itself has a lifetime much shorter than the period of one adiabatic cycle
Coupled effects of local movement and global interaction on contagion
By incorporating segregated spatial domain and individual-based linkage into
the SIS (susceptible-infected-susceptible) model, we investigate the coupled
effects of random walk and intragroup interaction on contagion. Compared with
the situation where only local movement or individual-based linkage exists, the
coexistence of them leads to a wider spread of infectious disease. The roles of
narrowing segregated spatial domain and reducing mobility in epidemic control
are checked, these two measures are found to be conducive to curbing the spread
of infectious disease. Considering heterogeneous time scales between local
movement and global interaction, a log-log relation between the change in the
number of infected individuals and the timescale is found. A theoretical
analysis indicates that the evolutionary dynamics in the present model is
related to the encounter probability and the encounter time. A functional
relation between the epidemic threshold and the ratio of shortcuts, and a
functional relation between the encounter time and the timescale are
found
A generalized public goods game with coupling of individual ability and project benefit
Facing a heavy task, any single person can only make a limited contribution
and team cooperation is needed. As one enjoys the benefit of the public goods,
the potential benefits of the project are not always maximized and may be
partly wasted. By incorporating individual ability and project benefit into the
original public goods game, we study the coupling effect of the four
parameters, the upper limit of individual contribution, the upper limit of
individual benefit, the needed project cost and the upper limit of project
benefit on the evolution of cooperation. Coevolving with the individual-level
group size preferences, an increase in the upper limit of individual benefit
promotes cooperation while an increase in the upper limit of individual
contribution inhibits cooperation. The coupling of the upper limit of
individual contribution and the needed project cost determines the critical
point of the upper limit of project benefit, where the equilibrium frequency of
cooperators reaches its highest level. Above the critical point, an increase in
the upper limit of project benefit inhibits cooperation. The evolution of
cooperation is closely related to the preferred group-size distribution. A
functional relation between the frequency of cooperators and the dominant group
size is found
Limitation of network inhomogeneity in improving cooperation in coevolutionary dynamics
Cooperative behavior is common in nature even if selfishness is sometimes
better for an individual. Empirical and theoretical studies have shown that the
invasion and expansion of cooperators are related to an inhomogeneous
connectivity distribution. Here we study the evolution of cooperation on an
adaptive network, in which an individual is able to avoid being exploited by
rewiring its link(s). Our results indicate that the broadening of connectivity
distribution is not always beneficial for cooperation. Compared with the
Poisson-like degree distribution, the exponential-like degree distribution is
detrimental to the occurrence of a higher level of cooperation in the
continuous snowdrift game (CSG)
Progesterone Administration Modulates Cortical TLR4/NF-κB Signaling Pathway after Subarachnoid Hemorrhage in Male Rats
Our previous study concerning brain trauma has shown that progesterone could regulate toll-like receptor 4 (TLR4) and nuclear factor-kappa B (NF-κB) signaling pathway in the brain, which also has been proved to play important roles in early brain injury (EBI) after subarachnoid hemorrhage (SAH). The aim of the current study was to investigate whether progesterone administration modulated TLR4/NF-κB pathway signaling pathway in the brain at the early stage of SAH. All SAH animals were subjected to injection of 0.3 ml fresh arterial, non-heparinized blood into prechiasmatic cistern in 20 seconds. Male rats were given 0 or 16 mg/kg injections of progesterone at post-SAH hours 1, 6, and 24. Brain samples were extracted at 48 h after SAH. As a result, SAH could induce a strong up-regulation of TLR4, NF-κB, pro-inflammatory cytokines, MCP-1, and ICAM-1 in the cortex. Administration of progesterone following SAH could down-regulate the cortical levels of these agents related to TLR4/NF-κB signaling pathway. Post-SAH progesterone treatment significantly ameliorated the EBI, such as the clinical behavior scale, brain edema, and blood-brain barrier (BBB) impairment. It was concluded that post-SAH progesterone administration may attenuate TLR4/NF-κB signaling pathway in the rat brain following SAH
Non-coding RNAs participate in the regulatory network of CLDN4 via ceRNA mediated miRNA evasion
AbstractThousands of genes have been well demonstrated to play important roles in cancer progression. As genes do not function in isolation, they can be grouped into “networks” based on their interactions. In this study, we discover a network regulating Claudin-4 in gastric cancer. We observe that Claudin-4 is up-regulated in gastric cancer and is associated with poor prognosis. Claudin-4 reinforce proliferation, invasion, and EMT in AGS, HGC-27, and SGC-7901 cells, which could be reversed by miR-596 and miR-3620-3p. In addition, lncRNA-KRTAP5-AS1 and lncRNA-TUBB2A could act as competing endogenous RNAs to affect the function of Claudin-4. Our results suggest that non-coding RNAs play important roles in the regulatory network of Claudin-4. As such, non-coding RNAs should be considered as potential biomarkers and therapeutic targets against gastric cancer.</jats:p
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