Research of NiMH Battery Modeling and Simulation Based on Linear Regression Analysis Method

 The battery state-of-charge estimation was one of core issues in the development of electric vehicles battery management system, and higher accurate model was needed in state-of-charge estimation correctly. Therefore, accurate battery modeling and simulation was researched here. The Thevenin equivalent circuit model of NiMH battery was established for the poor accuracy of traditional model. Based on the data which were brought from the 6V 6Ah NiMH battery hybrid pulse cycling test experiments, Thevenin model parameters were identified by means of the linear regression analysis method. Then, the battery equivalent circuit simulating model was built in the MATLAB/Simulink environment. The simulation and experimental results showed that the model has better accuracy and can be used to guide the battery state-of-charge estimation

Combined transarterial chemoembolization and arterial administration of Bletilla striata in treatment of liver tumor in rats

AIM: To evaluate and compare the effect of combined transarterial chemoembolization (TACE) and arterial administration of Bletilla striata (a Chinese traditional medicine against liver tumor) versus TACE alone for the treatment of hepatocellular carcinoma (HCC) in ACI rats. METHODS: Subcapsular implantation of a solid Morris hepatoma 3 924A (2 mm3) in the liver was carried out in 30 male ACI rats. Tumor volume (V1) was measured by magnetic resonance imaging (MRI) on day 13 after implantation. The following different agents of interventional treatment were injected after retrograde catheterization via gastroduodenal artery (on day 14), namely, (A) TACE (0.1 mg mitomycin + 0.1 ml Lipiodol) + Bletilla striata (1.0 mg) (n=10); (B) TACE + Bletilla striata (1.0 mg) + ligation of hepatic artery (n=10), (C) TACE alone (control group, n=10). Tumor volume (V2) was assessed by MRI (on day 13 after treatment) and the tumor growth ratio (V2/V1) was calculated. RESULTS: The mean tumor volume before (V1) and after (V2) treatment was 0.0355 cm3 and 0.2248 cm3 in group A, 0.0374 cm3 and 0.0573 cm3 in group B, 0.0380 cm3 and 0.3674 cm3 in group C, respectively. The mean ratio (V2/V1) was 6.2791 in group A, 1.5324 in group B and 9.1382 in group C. Compared with the control group (group C), group B showed significant inhibition of tumor growth (P0.05). None of the animals died during implantation or in the postoperative period. CONCLUSION: Combination of TACE and arterial administration of Bletilla striata plus ligation of hepatic artery is more effective than TACE alone in the treatment of HCC in rats

Study on the Road Network Connectivity Reliability of Valley City Based on Complex Network

Based on the research progress in related fields and the distribution characteristics of road networks in valley cities, the complex network model of a city road network is established to study its connectivity reliability. Taking Lanzhou as the example, several parameters of the complex network abstracted from the road network are calculated and the practical meanings of them are described, respectively. On this basis, through computing the global efficiency and the relative size of the largest connecting subgraph under intentional attacks and random attacks, respectively, the curves of the above two parameters varying with the attacking times are drawn. The detailed investigation of connectivity reliability of Lanzhou road network is done by analyzing the curves’ tendency. Finally, we find that the network of a valley city has a poor connection and has a lot of dead ends. Besides, the average length of the roads is very long and the holistic connectivity reliability is at a lower level; these are suitable to the group-type distribution of valley city’s road network, and the connectivity reliability of the road network is stronger under random attacks than that under intentional attacks

Short-Term Traffic Prediction Based on Genetic Algorithm Improved Neural Network

This paper takes the time series of short-term traffic flow as research object. The delay time and embedding dimension are calculated by C-C algorithm, and the chaotic characteristics of the time series are verified by small data sets method.Then based on the neural network prediction model and the chaotic phase space reconstruction theory, the network topology is determined, and the prediction is conducted by the wavelet neural network and RBF neural network using Lan-Hai expressway experimental data. The results show that the prediction effect of RBF neural network is better. Due to the poor stability of the network caused by the initial parameters randomness, the genetic algorithm is used to optimize the initial parameters. The results show that the prediction error of the optimized wavelet neural network or RBF neural network is reduced by more than 10%, and prediction accuracy of the latter is better

Toxicities comparison of rotenone and acetone extract of Tephrosiavogelii and Derris trifoliate against Solenopsis invicta

The high rotenone content and the rotenone crude extract of Tephrosia vogelii and Derris trifoliata were evaluated for its efficacy in the control of red imported fire (RIFA), Solenopsis invicta under both laboratory and field conditions. The acetone extracts of D. trifoliata roots and T. vogelii leaves exhibited strong toxicity to macroergate and micrergate of RIFA. When active ingredients of the crude extracts were convert to rotenone, the activity of the acetone extracts were higher than that of rotenone technical material. At the same time, the extracts showed significant inhibitory effect on walking ability and grasping ability of worker ants and stronger than the effect of 98.6% rotenone technical material. Under field conditions, the 0.01% rotenone-bait, formulated with the acetone extract of D. trifoliata roots and T. vogelii leaves, had the same control effect on RIFA as that of 0.01% fipronil-bait when treated after 30 d. The bait formulated with the extract of D. trifoliata exhibited quicker and higher effect on RIFA than that of rotenone technical material. It was showed that the acetone extracts of D. trifoliata roots and T. vogelii leaves are able to control S. invicta under both laboratory and field conditions and can be used as an effective agent against RIFA

Characterisation of volatile components of red and sparkling wines from a new wine grape cultivar 'Meili' (Vitis vinifera L.)

'Meili' (Vitis vinifera L.) is a new wine grape cultivar from China. Volatile profiles of red and sparkling wines made from 'Meili' grapes were analysed using stir bar sorptive extraction-gas chromatography-mass spectrometry in this study. Fiftyfive volatile compounds were quantified in both wines, and quantitative differences for most of the volatile compounds between 'Meili' wines were observed. 'Meili' sparkling wine had a greater content of esters, fatty acids and shikimic acid derivatives than 'Meili' red wine, although 'Meili' red wine had higher concentrations of alcohols, terpenoids and C13-norisoprenoids. On the basis of odour activity values, ethyl acetate, ethyl butanoate, ethyl hexanoate, ethyl octanoate, isoamyl acetate, ethyl 2-methylpropanoate, ethyl 3-methylbutanoate, octanoic acid, isoamyl alcohol, 2-phenyl ethanol, linalool, β-damascenone and β-ionone were considered as important aroma compounds in 'Meili' wines. For these compounds, 'Meili' sparkling wine had higher content of ethyl acetate, ethyl butanoate, ethyl hexanoate, ethyl octanoate and isoamyl acetate than 'Meili' red wine, while 'Meili' red wine had higher levels of isoamyl alcohol, 2-phenylethanol, linalool, β-damascenone and β-ionone. The concentration differences of aroma compounds due to the differential vinification procedures suggested the differences in sensory characteristics of the two types of wines. In particular, 'Meili' red wine had more rose aroma than 'Meili' sparkling wine.

Prognosticators and Risk Grouping in Patients with Lung Metastasis from Nasopharyngeal Carcinoma: A more accurate and appropriate assessment of prognosis

<p>Abstract</p> <p>Background</p> <p>Lung metastases arising from nasopharyngeal carcinomas (NPC) have a relatively favourable prognosis. The purpose of this study was to identify the prognostic factors and to establish a risk grouping in patients with lung metastases from NPC.</p> <p>Methods</p> <p>A total of 198 patients who developed lung metastases from NPC after primary therapy were retrospectively recruited from January 1982 to December 2000. Univariate and multivariate analyses of clinical variables were performed using Cox proportional hazards regression models. Actuarial survival rates were plotted against time using the Kaplan-Meier method, and log-rank testing was used to compare the differences between the curves.</p> <p>Results</p> <p>The median overall survival (OS) period and the lung metastasis survival (LMS) period were 51.5 and 20.9 months, respectively. After univariate and multivariate analyses of the clinical variables, age, T classification, N classification, site of metastases, secondary metastases and disease-free interval (DFI) correlated with OS, whereas age, VCA-IgA titre, number of metastases and secondary metastases were related to LMS. The prognoses of the low- (score 0-1), intermediate- (score 2-3) and high-risk (score 4-8) subsets based on these factors were significantly different. The 3-, 5- and 10-year survival rates of the low-, intermediate- and high-risk subsets, respectively (P < 0.001) were as follows: 77.3%, 60% and 59%; 52.3%, 30% and 27.8%; and 20.5%, 7% and 0%.</p> <p>Conclusions</p> <p>In this study, clinical variables provided prognostic indicators of survival in NPC patients with lung metastases. Risk subsets would help in a more accurate assessment of a patient's prognosis in the clinical setting and could facilitate the establishment of patient-tailored medical strategies and supports.</p

Anti-tumor activity of N-trimethyl chitosan-encapsulated camptothecin in a mouse melanoma model

<p>Abstract</p> <p>Background</p> <p>Camptothecin (CPT) has recently attracted increasing attention as a promising anticancer agent for a variety of tumors. But the clinical application is largely hampered by its extreme water insolubility and unpredictable side effect. It is essential to establish an efficient and safe protocol for the administration of CPT versus melanoma.</p> <p>Methods</p> <p>Camptothecin was encapsulated with N-trimethyl chitosan (CPT-TMC) through microprecipitation and sonication. Its inhibition effect on B16-F10 cell proliferation and induction of apoptosis was evaluated by MTT assay and flow cytometric analysis in vitro. The anti-tumor activity of CPT-TMC was evaluated in C57BL/6 mice bearing B16-F10 melanoma. Tumor volume, tumor weight and survival time were recorded. Assessment of apoptotic cells within tumor tissue was performed by TUNEL assay. Antiangiogenesis and antiproliferation effects of CPT-TMC in vivo were conducted via CD31 and PCNA immunohistochemistry, respectively.</p> <p>Results</p> <p>CPT-TMC efficiently inhibited B16-F10 cells proliferation and increased apoptosis in vitro. Experiment group showed significant inhibition compared with free CPT-treated group (81.3% vs. 56.9%) in the growth of B16-F10 melanoma xenografts and prolonged the survival time of the treated mice (P < 0.05). Decreased cell proliferation, increased tumor apoptosis as well as a reduction in angiogenesis were observed.</p> <p>Conclusions</p> <p>Our data suggest that N-trimethyl chitosan-encapsulated camptothecin is superior to free CPT by overcoming its insolubility and finally raises the potential of its application in melanoma therapy.</p

Research Progress in the Mechanism of Effect of PRP in Bone Deficiency Healing

Platelet-rich plasma (PRP) therapy is a recently developed technique that uses a concentrated portion of autologous blood to try to improve and accelerate the healing of various tissues. There is a considerable interest in using these PRP products for the treatment used in bone deficiency healing. Because PRP products are safe and easy to prepare and administer, there has been increased attention toward using PRP in numerous clinical settings. The benefits of PRP therapy appear to be promising, and many investigators are exploring the ways in which this therapy can be used in the clinical setting. At present, the molecular mechanisms of bone defect repair studies have focused on three aspects of the inflammatory cytokines, growth factors and angiogenic factors. The role of PRP works mainly through these three aspects of bone repair. The purpose of this paper is to review the current evidence on the mechanism of the effect of PRP in bone deficiency healing