Impact of Vegetation on Land-Atmosphere Coupling Strength and Its Implication for Desertification Mitigation over East Asia

Desertification of the East Asian drylands and the consequent dust transport have been serious concerns for adjacent Asian countries as well as the western United States. Tree planting has been considered one applicable strategy to mitigate the desertification. However, the desired effect of the tree planting would not be brought to fruition unless the newly planted trees change the coupling characteristics between the land and the atmosphere. Based on this perception, we attempt to clarify the effects of vegetation on the coupling strength between the atmosphere and land surface, and we suggest the most efficient areas of tree planting for desertification mitigation in East Asia. Using regional vegetation-atmosphere coupled model simulations, coupling strength with and without vegetation was computed and compared with each other. An increased vegetation fraction reduces the coupling strength in June, July, and August (JJA), primarily due to decreased evapotranspiration variability. This effect is pronounced over the Manchurian Plains and the highly populated areas of Beijing and Tianjin. The reduced coupling strength tends to weaken feedback between soil moisture and precipitation as a maintenance mechanism of warm season droughts in the midlatitudes and subsequently decrease the probability of droughts, a finding that is reflected in the enhanced JJA mean soil moisture. However, some drylands like the eastern edges of the Gobi desert present marginal or even opposite changes in coupling strength, meaning a limited effect of vegetation on relieving droughts. Therefore, given limited financial and human resources, acupuncture-like afforestation, i.e., concentrated tree planting in a particular region where the coupling strength can be substantially reduced by vegetation, is an effective strategy to secure long-standing desertification mitigation

Inter- and Intra-Annual Variability of Vegetation in the Northern Hemisphere and Its Association with Precursory Meteorological Factors

Determination of phenological variation is one of the most critical challenges in dynamic vegetation modeling, given the lack of a strong theoretical framework. Previous studies generally focused on the timing of a phenological event (e.g., bud-burst or onset of growing season) and its atmospheric prompts, but not on the interactive variations across phenological stages. This study, therefore, investigated the inter- and intra-annual variability existing in all the phenological stages and the relations of the variability with four meteorological variables (surface temperature (Ts), shortwave radiation (SW ), vapor pressure deficit (VPD), and precipitation (PRCP)) using a 25-year (1982-2006) dataset of leaf area index (LAI) from the Advanced Very High Resolution Radiometer (AVHRR). Our six study sites of each 4 degree x 4 degree grids (mixed forest in China, deciduous needle-leaf forest in Siberia, evergreen needle-leaf forest in western Canada, grass in Gobi, and crops in the Central United States and southeastern Europe) include various vegetation types, local climates, and land-use types in the mid-latitudes of the northern hemisphere. Empirical orthogonal function (EOF) analysis with detrended LAI anomalies identified the two leading EOF modes that account for the amplitude and phase of the monthly LAI variations. The inter-annual correlation between the principle components (PCs) of the two modes and the meteorological variables for spring and summer showed that the amplitude and phase modes (AM and PM, respectively) were affected by different dominant meteorological factors. Over most of the study regions, AM was positively correlated with PRCP and negatively with Ts, SW, and VPD,while PMwas predominantly positively correlated with Ts. The contrasting responses of the two EOFmodes to Ts reflect environmental limitations on plant growth such as early start of growth, but with a reduced value of maximum LAI in a year with a warm spring. In addition, insignificant correlations between AMand PRCP, as well as negative correlations between PM and PRCP, in the crop regions suggest that human interventions such as advanced irrigation systems also play a key role in vegetative activity

Tangled plastic biliary stents removed using a rendezvous method

Biliary stents are used to facilitate the drainage of bile into the digestive tract, most often in the palliation of malignant biliary obstruction, but also in benign conditions such as biliary fistulas or benign biliary strictures. Temporary multiple double-pigtail biliary stenting is a safe method for treating large, difficult common bile duct (CBD) stones in elderly patients; it helps reduce stone size and facilitates successful duct clearance. We report a new technique for retrieving two tangled plastic biliary stents using rendezvous endoscopic retrograde cholangiopancreatography (ERCP) and percutaneous transhepatic biliary drainage

Influence of non-feedback variations of radiation on the determination of climate feedback

Recent studies have estimated the magnitude of climate feedback based on the correlation between time variations in outgoing radiation flux and sea surface temperature (SST). This study investigates the influence of the natural non-feedback variation (noise) of the flux occurring independently of SST on the determination of climate feedback. The observed global monthly radiation flux is used from the Clouds and the Earth's Radiant Energy System (CERES) for the period 2000–2008. In the observations, the time lag correlation of radiation and SST shows a distorted curve with low statistical significance for shortwave radiation while a significant maximum at zero lag for longwave radiation over the tropics. This observational feature is explained by simulations with an idealized energy balance model where we see that the non-feedback variation plays the most significant role in distorting the curve in the lagged correlation graph, thus obscuring the exact value of climate feedback. We also demonstrate that the climate feedback from the tropical longwave radiation in the CERES data is not significantly affected by the noise. We further estimate the standard deviation of radiative forcings (mainly from the noise) relative to that of the non-radiative forcings, i.e., the noise level from the observations and atmosphere–ocean coupled climate model simulations in the framework of the simple model. The estimated noise levels in both CERES (>13 %) and climate models (11–28 %) are found to be far above the critical level (~5 %) that begins to misrepresent climate feedback.Korea. Meteorological Administration. Research and Development Program (grant CATER 2012–3064)National Research Foundation of Korea (MSIP) (2009-83527

Carbon monoxide inhibits Fas activating antibody-induced apoptosis in endothelial cells

<p>Abstract</p> <p>Background</p> <p>The extrinsic apoptotic pathway initiates when a death ligand, such as the Fas ligand, interacts with its cell surface receptor (<it>ie</it>., Fas/CD95), forming a death-inducing signaling complex (DISC). The Fas-dependent apoptotic pathway has been implicated in several models of lung or vascular injury. Carbon monoxide, an enzymatic product of heme oxygenase-1, exerts antiapoptotic effects at low concentration <it>in vitro </it>and <it>in vivo</it>.</p> <p>Methods</p> <p>Using mouse lung endothelial cells (MLEC), we examined the antiapoptotic potential of carbon monoxide against apoptosis induced by the Fas/CD95-activating antibody (Jo2). Carbon monoxide was applied to cell cultures <it>in vitro</it>. The expression and/or activation of apoptosis-related proteins and signaling intermediates were determined using Western Immunoblot and co-immunoprecipitation assays. Cell death was monitored by lactate dehydrogenase (LDH) release assays. Statistical significance was determined by student T-test and a value of <it>P </it>< 0.05 was considered significant.</p> <p>Results</p> <p>Treatment of MLEC with Fas-activating antibody (Jo2) induced cell death associated with the formation of the DISC, and activation of caspases (-8, -9, and -3), as well as the pro-apoptotic Bcl-2 family protein Bax. Exposure of MLEC to carbon monoxide inhibited Jo2-induced cell death, which correlated with the inhibition of DISC formation, cleavage of caspases-8, -9, and -3, and Bax activation. Carbon monoxide inhibited the phosphorylation of the Fas-associated death domain-containing protein, as well as its association with the DISC. Furthermore, carbon monoxide induced the expression of the antiapoptotic protein FLIP and increased its association with the DISC.</p> <p>CO-dependent cytoprotection against Fas mediated apoptosis in MLEC depended in part on activation of ERK1/2-dependent signaling.</p> <p>Conclusions</p> <p>Carbon monoxide has been proposed as a potential therapy for lung and other diseases based in part on its antiapoptotic effects in endothelial cells. In vitro, carbon monoxide may inhibit both Fas/caspase-8 and Bax-dependent apoptotic signaling pathways induced by Fas-activating antibody in endothelial cells. Strategies to block Fas-dependent apoptotic pathways may be useful in development of therapies for lung or vascular disorders.</p

Effect of preoperative statin therapy on myocardial protection and morbidity endpoints following off-pump coronary bypass surgery in patients with elevated C-reactive protein level

BACKGROUND: The aim of this study was to investigate the effects of preoperative statin therapy on myocardial protection and morbidity endpoints following off-pump coronary bypass graft surgery (OPCAB) in patients with elevated serum high-sensitivity C-reactive protein (hs-CRP) levels. METHODS: Of the 492 patients who underwent multivessel OPCAB from March 2007 to February 2009, the records of 144 patients whose baseline hs-CRP level > 2 mg/L were reviewed. According to the history of preoperative statin therapy for at least one week, patients were classified as either statin group or control group (72 subjects each). Preoperative and operative characteristics and postoperative data including troponin (Tn)-T level and major morbidity endpoints were obtained and compared. Major morbidity endpoints were defined as permanent stroke, renal dysfunction, hemostatic re-exploration, deep sternal wound infection, and the number of patients requiring prolonged ventilation. RESULTS: Preoperative and operative characteristics were similar between the two groups. There were no significant differences in the incidence of morbidity endpoints between the two groups, except for the number of patients requiring dialysis, which was significantly lower in the statin group (8 vs. 1, P = 0.033). Tn-T level at 24 h after surgery was also significantly lower in the statin group. CONCLUSIONS: In this study, we observed beneficial effects of preoperative statin therapy for at least one week in terms of less myocardial enzyme release and fewer patients requiring dialysis following OPCAB in patients whose preoperative hs-CRP was elevatedope

Application of the Whole Genome-Based Bacterial Identification System, TrueBac ID, Using Clinical Isolates That Were Not Identified With Three Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) Systems

Background: Next-generation sequencing is increasingly used for taxonomic identification of pathogenic bacterial isolates. We evaluated the performance of a newly introduced whole genome-based bacterial identification system, TrueBac ID (ChunLab Inc., Seoul, Korea), using clinical isolates that were not identified by three matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) systems and 16S rRNA gene sequencing. Methods: Thirty-six bacterial isolates were selected from a university-affiliated hospital and a commercial clinical laboratory. Species was identified by three MALDI-TOF MS systems: Bruker Biotyper MS (Bruker Daltonics, Billerica, MA, USA), VITEK MS (bioMerieux, Marcy l'Etoile, France), and ASTA MicrolDSys (ASTA Inc., Suwon, Korea). Whole genome sequencing was conducted using the Illumina MiSeq system (Illumina, San Diego, CA, USA), and genome-based identification was performed using the TrueBac ID cloud system (www.truebacid.com ). Results: TrueBac ID assigned 94% (34/36) of the isolates to known (N=25) or novel (N=4) species, genomospecies (N=3), or species group (N=2). The remaining two were identified at the genus level. Conclusions: TrueBac ID successfully identified the majority of isolates that MALDI-TOF MS failed to identify. Genome-based identification can be a useful tool in clinical laboratories, with its superior accuracy and database-driven operations.

Extreme hyponatremia with moderate metabolic acidosis during hysteroscopic myomectomy -A case report-

Excess absorption of fluid distention media remains an unpredictable complication of operative hysteroscopy and may lead to lethal conditions. We report an extreme hyponatremia, caused by using an electrolyte-free 5 : 1 sorbitol/mannitol solution as distention/irrigation fluid for hysteroscopic myomectomy. A 34-year-old female developed severe pulmonary edema and extreme hyponatremia (83 mmol/L) during transcervical endoscopic myomectomy. A brain computed tomography showed mild brain swelling without pontine myelinolysis. The patient almost fully recovered in two days. Meticulous attention should be paid to intraoperative massive absorption of fluid distention media, even during a simple hysteroscopic procedure