The Role of Donated Labour and Not for Profit at the Public/Private Interface

The aim of this paper is to assess the role of donated labour and not-for-profit (NFP) entities at the public private interface. After discussing what a NFP enterprise is and providing general background, we look at the underlying theory of NFP institutions. The fact that NFP companies are able to precommit themselves not to expropriate donated labour is identified as a primary justification of the NFP model and we emphasise the role that purchasers play in the expropriation problem and suggest that this is a particular concern for institutions at the public private interface. After summarising the empirical literature we provide a brief case study of Glas Cymru and show that it is likely to fall foul of the purchaser problems in that the structure makes it hard to avoid expropriation of donated labour. Although there is limited empirical evidence investigation of what is available suggests that the shift from FP to NFP has had no significant effect on the company. Finally, we address the issue of Foundation Hospitals and suggest that there is more, albeit limited, reason to suggest that the NFP status will prove beneficial for donating labour.not-for-profit, public private interface

Entropic Priors and Bayesian Model Selection

We demonstrate that the principle of maximum relative entropy (ME), used judiciously, can ease the specification of priors in model selection problems. The resulting effect is that models that make sharp predictions are disfavoured, weakening the usual Bayesian "Occam's Razor". This is illustrated with a simple example involving what Jaynes called a "sure thing" hypothesis. Jaynes' resolution of the situation involved introducing a large number of alternative "sure thing" hypotheses that were possible before we observed the data. However, in more complex situations, it may not be possible to explicitly enumerate large numbers of alternatives. The entropic priors formalism produces the desired result without modifying the hypothesis space or requiring explicit enumeration of alternatives; all that is required is a good model for the prior predictive distribution for the data. This idea is illustrated with a simple rigged-lottery example, and we outline how this idea may help to resolve a recent debate amongst cosmologists: is dark energy a cosmological constant, or has it evolved with time in some way? And how shall we decide, when the data are in?Comment: Presented at MaxEnt 2009, the 29th International Workshop on Bayesian Inference and Maximum Entropy Methods in Science and Engineering (July 5-10, 2009, Oxford, Mississippi, USA

Single-crystal X-ray diffraction and resonant X-ray magnetic scattering at helium-3 temperatures in high magnetic fields at beamline P09 at PETRA III

The resonant scattering and diffraction beamline P09 at PETRA III at DESY is equipped with a 14 T vertical field split-pair magnet. A helium-3 refrigerator is available that can be fitted inside the magnet\u27s variable-temperature insert. Here the results of a series of experiments aimed at determining the beam conditions permitting operations with the He-3 insert are presented. By measuring the tetragonal-to-orthorhombic phase transition occurring at 2.1 K in the Jahn-Teller compound TmVO4, it is found that the photon flux at P09 must be attenuated down to 1.5 × 109 photons s-1 for the sample to remain at temperatures below 800 mK. Despite such a reduction of the incident flux and the subsequent use of a Cu(111) analyzer, the resonant X-ray magnetic scattering signal at the Tm LIII absorption edge associated with the spin-density wave in TmNi2B2C below 1.5 K is intense enough to permit a complete study in magnetic field and at sub-Kelvin temperatures to be carried out

Efficient, D-glucose insensitive, growth on D-xylose by an evolutionary engineered Saccharomyces cerevisiae strain

Optimizing D-xylose consumption in Saccharomyces cerevisiae is essential for cost-efficient cellulosic bioethanol production. An evolutionary engineering approach was used to elevate D-xylose consumption in a xylose-fermenting S. cerevisiae strain carrying the D-xylose-specific N367I mutation in the endogenous chimeric Hxt36 hexose transporter. This strain carries a quadruple hexokinase deletion that prevents glucose utilization, and allows for selection of improved growth rates on D-xylose in the presence of high D-glucose concentrations. Evolutionary engineering resulted in D-glucose-insensitive growth and consumption of D-xylose which could be attributed to glucose insensitive D-xylose uptake via a novel chimeric Hxt37 N367I transporter that emerged from a fusion of the HXT36 and HXT7 genes, and a down regulation of a set of Hxt transporters that mediate glucose sensitive xylose transport. RNA sequencing revealed the down-regulation of HXT1 and HXT2 which, together with the deletion of HXT7, resulted in a 21% reduction of the expression of all plasma membrane transporters genes. Morphological analysis showed an increased cell size and corresponding increased cell surface area of the evolved strain, which could be attributed to genome duplication. Mixed strain fermentation of the D-xylose-consuming strain DS71054-evo6 with the D-glucose consuming CEN.PK113-7D strain resulted in decreased residual sugar concentrations and improved ethanol production yields compared to a strain which sequentially consumes D-glucose and D-xylose

Aromatic Features in AGN: Star-Forming Infrared Luminosity Function of AGN Host Galaxies

We describe observations of aromatic features at 7.7 and 11.3 um in AGN of three types including PG, 2MASS and 3CR objects. The feature has been demonstrated to originate predominantly from star formation. Based on the aromatic-derived star forming luminosity, we find that the far-IR emission of AGN can be dominated by either star formation or nuclear emission; the average contribution from star formation is around 25% at 70 and 160 um. The star-forming infrared luminosity functions of the three types of AGN are flatter than that of field galaxies, implying nuclear activity and star formation tend to be enhanced together. The star-forming luminosity function is also a function of the strength of nuclear activity from normal galaxies to the bright quasars, with luminosity functions becoming flatter for more intense nuclear activity. Different types of AGN show different distributions in the level of star formation activity, with 2MASS> PG> 3CR star formation rates.Comment: Accepted for publication in ApJ, 24 pages, 13 figure

A global view of the oncogenic landscape in nasopharyngeal carcinoma : an integrated analysis at the genetic and expression levels

Previous studies have reported that the tumour cells of nasopharyngeal carcinoma (NPC) exhibit recurrent chromosome abnormalities. These genetic changes are broadly assumed to lead to changes in gene expression which are important for the pathogenesis of this tumour. However, this assumption has yet to be formally tested at a global level. Therefore a genome wide analysis of chromosome copy number and gene expression was performed in tumour cells micro-dissected from the same NPC biopsies. Cellular tumour suppressor and tumour-promoting genes (TSG, TPG) and Epstein-Barr Virus (EBV)-encoded oncogenes were examined. The EBV-encoded genome maintenance protein EBNA1, along with the putative oncogenes LMP1, LMP2 and BARF1 were expressed in the majority of NPCs that were analysed. Significant downregulation of expression in an average of 76 cellular TSGs per tumour was found, whilst a per-tumour average of 88 significantly upregulated, TPGs occurred. The expression of around 60% of putative TPGs and TSGs was both up-and down-regulated in different types of cancer, suggesting that the simplistic classification of genes as TSGs or TPGs may not be entirely appropriate and that the concept of context-dependent onco-suppressors may be more extensive than previously recognised. No significant enrichment of TPGs within regions of frequent genomic gain was seen but TSGs were significantly enriched within regions of frequent genomic loss. It is suggested that loss of the FHIT gene may be a driver of NPC tumourigenesis. Notwithstanding the association of TSGs with regions of genomic loss, on a gene by gene basis and excepting homozygous deletions and high-level amplification, there is very little correlation between chromosomal copy number aberrations and expression levels of TSGs and TPGs in NPC

Uplift, Climate and Biotic Changes at the Eocene-Oligocene Transition in Southeast Tibet

The uplift history of southeastern Tibet is crucial to understanding processes driving the tectonic evolution of the Tibetan Plateau and surrounding areas. Underpinning existing palaeoaltimetric studies has been regional mapping based in large part on biostratigraphy that assumes a Neogene modernisation of the highly diverse, but threatened, Asian biota. Here, with new radiometric dating and newly-collected plant fossil archives, we quantify the surface height of part of Tibet’s southeastern margin of Tibet in the latest Eocene (~34 Ma) to be ~3 km and rising, possibly attaining its present elevation (3.9 km) in the early Oligocene. We also find that the Eocene-Oligocene transition in southeastern Tibet witnessed leaf size diminution and a floral composition change from sub-tropical/warm temperate to cool temperate, likely reflective of both uplift and secular climate change, and that by the latest Eocene floral modernization on Tibet had already taken place implying modernization was deeply-rooted in the Paleogene

A cis-Acting Element in Retroviral Genomic RNA Links Gag-Pol Ribosomal Frameshifting to Selective Viral RNA Encapsidation

SummaryDuring retroviral RNA encapsidation, two full-length genomic (g) RNAs are selectively incorporated into assembling virions. Packaging involves a cis-acting packaging element (Ψ) within the 5′ untranslated region of unspliced HIV-1 RNA genome. However, the mechanism(s) that selects and limits gRNAs for packaging remains uncertain. Using a dual complementation system involving bipartite HIV-1 gRNA, we observed that gRNA packaging is additionally dependent on a cis-acting RNA element, the genomic RNA packaging enhancer (GRPE), found within the gag p1-p6 domain and overlapping the Gag-Pol ribosomal frameshift signal. Deleting or disrupting the two conserved GRPE stem loops diminished gRNA packaging and infectivity >50-fold, while deleting gag sequences between Ψ and GRPE had no effect. Downregulating the translation termination factor eRF1 produces defective virus particles containing 20 times more gRNA. Thus, only the HIV-1 RNAs employed for Gag-Pol translation may be specifically selected for encapsidation, possibly explaining the limitation of two gRNAs per virion

Charge-swapping q balls

© 2014 American Physical Society. Q balls are nontopological solitonic solutions to a wide class of field theories that possess global symmetries. Here we show that in these same theories there also exists a tower of novel composite Q-ball solutions where, within one composite Q ball, positive and negative charges coexist and swap at a frequency lower than the natural frequency of an individual Q ball. These charge-swapping Q balls are constructed by assembling Q balls and anti-Q balls tightly such that their nonlinear cores overlap. We explain why charge-swapping Q balls can form and why they swap charges